Wednesday, September 17, 2025 9/17/2025

Renewal of the Human Islet Research Enhancement Center (HIREC) for the Type-1-Diabetes-Focused Human Islet Research Network (HIRN).

Award Number: U24DK104162
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2014
PERIOD OF PERFORMANCE END DATE: 06/30/2029

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Renewal of the Human Islet Research Enhancement Center (HIREC) for the Type-1-Diabetes-Focused Human Islet Research Network (HIRN). - ABSTRACT The scale and scope of scientific collaborations in the Human Islet Research Network (HIRN) bring together extraordinary resources to solve complex problems in type 1 diabetes (T1D). To capitalize on this initiative, extensive efforts are required to coordinate, communicate, and catalyze research effectively. The City of Hope is applying to renew the Human Islet Research Enhancement Center (HIREC), providing the administrative and scientific infrastructure needed for day-to-day operations of the HIRN and capitalizing on existing and emerging resources to propel it forward as an innovative team science engine in T1D research. The specific aims of this project were formed to address critical challenges and requirements, or put simply to engineer, enrich, and empower the future of HIRN. The established team is not only experienced in establishing data centers, systems, and resource distribution networks critical to the HIRN, but also are researchers with expertise in T1D disease pathogenesis, biostatistics, bioinformatics, computational biology, data science, semantic technologies, software development, and the use of Findable, Accessible, Interoperable, and Reusable (FAIR) principles. Discoveries arising from HIRN will profoundly improve our understanding of T1D pathogenesis and expedite the advancement of disease prevention and treatment strategies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,590,381 )
2025	2025	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	004	12	7/24/2025	NON-COMPETING CONTINUATION	$1,590,381
2025	2024	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	11	6/25/2025	COMPETING CONTINUATION	$0
2025	2024	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	11	10/23/2024	COMPETING CONTINUATION	$0
2025	2024	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	11	5/7/2025	COMPETING CONTINUATION	$366,661
2025	2024	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	005	11	7/31/2025	COMPETING CONTINUATION	$0
2025	2023	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	10	5/7/2025	NON-COMPETING CONTINUATION	-$366,661
														Subtotal = $1,590,381

Issue Date FY: 2024 ( Subtotal = $1,612,983 )
2024	2024	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	11	9/13/2024	COMPETING CONTINUATION	$0
2024	2024	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	11	8/29/2024	COMPETING CONTINUATION	$1,612,983
2024	2023	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	2/21/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,612,983

Issue Date FY: 2023 ( Subtotal = $1,499,999 )
2023	2023	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	10	7/25/2023	NON-COMPETING CONTINUATION	$1,499,999
2023	2023	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	10	9/23/2023	NON-COMPETING CONTINUATION	$0
2023	2022	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	9	2/3/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,499,999

Issue Date FY: 2022 ( Subtotal = $1,499,999 )
2022	2022	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	9	9/8/2022	NON-COMPETING CONTINUATION	$0
2022	2022	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	9	8/2/2022	NON-COMPETING CONTINUATION	$1,499,999
2022	2021	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	8	2/16/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,499,999

Issue Date FY: 2021 ( Subtotal = $1,499,999 )
2021	2021	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	8	8/12/2021	NON-COMPETING CONTINUATION	$1,499,999
2021	2020	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	7	1/15/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,499,999

Issue Date FY: 2020 ( Subtotal = $2,420,187 )
2020	2020	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	004	7	7/9/2020	NON-COMPETING CONTINUATION	$1,499,999
2020	2019	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	6	4/7/2020	COMPETING CONTINUATION	$0
2020	2019	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	6	2/20/2020	COMPETING CONTINUATION	$921,942
2020	2019	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	6	4/16/2020	COMPETING CONTINUATION	$0
2020	2019	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	6	3/19/2020	COMPETING CONTINUATION	-$1,754
														Subtotal = $2,420,187

Issue Date FY: 2019 ( Subtotal = $1,499,999 )
2019	2019	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1500 DUARTE RD	DUARTE	CA	91010	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	6	8/6/2019	COMPETING CONTINUATION	$1,499,999
														Subtotal = $1,499,999

Grand Total All Awards = $11,623,547

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Renewal of the Human Islet Research Enhancement Center (HIREC) for the Type-1-Diabetes-Focused Human Islet Research Network (HIRN).

Award Number: U24DK104162

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2014

PERIOD OF PERFORMANCE END DATE: 06/30/2029

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