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Continuation of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Data Coordinating Center

Award Number: U24DK099879
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary In the Continuation of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN II), the investigators will advance the subtyping of study participants with Lower Urinary Tract Symptoms (LUTS) with the expectation that clinically useful patient subtypes will be identified. Research efforts will include continued analysis of data and biospecimens from LURN I and development of additional, new and novel collaborative studies to further improve our understanding of lower urinary tract dysfunction, both designed to generate findings that may inform future clinical studies (e.g., clinical treatment trials) and ultimately improve clinical management and patient outcomes. Studies will also refine and evaluate the longitudinal performance of clusters identified in LURN I for patient subtyping, including response to treatment. We will incorporate insights from the LURN I organ-based diagnostics pilot study and biomarker pilot studies. We will evaluate the LURN Comprehensive Assessment of Self-reported Urinary Symptoms (CASUS) instrument in populations with lesser severity of LUTS than seen in the tertiary care setting in LURN I. Consistent with the description in the RFA for this second funding cycle of LURN, the primary goal of this proposal is to better define clinical phenotypes of patients with LUTS, to better describe the impact and diversity of symptoms, and to develop new patient-centric tools for improved measurement of clinical symptoms, all with the goals of informing future clinical studies and improving patient care and outcomes. It is anticipated that the network will consist of up to six clinical sites and a single data coordinating center (DCC). The DCC for the LURN study is charged with providing coordination, communications and logistical support, clinical study design, centralized data management, biosample management, quality assurance, and analytical support to the research sites and the NIDDK Project Scientist for all LURN studies. The proposing team is submitting this response to RFA-DK-18-511 to continue as the DCC for the network.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	ARBOR RESEARCH COLLABORATIVE FOR HEALTH	3989 RESEARCH PARK DRIVE	ANN ARBOR	MI	48108	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	8	12/5/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $1,047,930 )
2023	2023	ARBOR RESEARCH COLLABORATIVE FOR HEALTH	3989 RESEARCH PARK DRIVE	ANN ARBOR	MI	48108	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	8/9/2023	NON-COMPETING CONTINUATION	$1,047,930
2023	2023	ARBOR RESEARCH COLLABORATIVE FOR HEALTH	3989 RESEARCH PARK DRIVE	ANN ARBOR	MI	48108	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	10	8/31/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,047,930

Issue Date FY: 2022 ( Subtotal = $1,064,951 )
2022	2022	ARBOR RESEARCH COLLABORATIVE FOR HEALTH	3700 EARHART ROAD	ANN ARBOR	MI	48105	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	9	9/14/2022	NON-COMPETING CONTINUATION	$0
2022	2022	ARBOR RESEARCH COLLABORATIVE FOR HEALTH	3700 EARHART ROAD	ANN ARBOR	MI	48105	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	9	9/6/2022	NON-COMPETING CONTINUATION	$1,064,951
														Subtotal = $1,064,951

Issue Date FY: 2021 ( Subtotal = $1,020,143 )
2021	2021	ARBOR RESEARCH COLLABORATIVE FOR HEALTH	3700 EARHART ROAD	ANN ARBOR	MI	48105	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	8	9/10/2021	NON-COMPETING CONTINUATION	$1,020,143
2021	2020	ARBOR RESEARCH COLLABORATIVE FOR HEALTH	3700 EARHART ROAD	ANN ARBOR	MI	48105	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	7	9/9/2021	NON-COMPETING CONTINUATION	$0
2021	2020	ARBOR RESEARCH COLLABORATIVE FOR HEALTH	3700 EARHART ROAD	ANN ARBOR	MI	48105	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	7	1/21/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,020,143

Issue Date FY: 2020 ( Subtotal = $1,120,209 )
2020	2020	ARBOR RESEARCH COLLABORATIVE FOR HEALTH	3700 EARHART ROAD	ANN ARBOR	MI	48105	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	7	8/31/2020	NON-COMPETING CONTINUATION	$999,999
2020	2020	ARBOR RESEARCH COLLABORATIVE FOR HEALTH	3700 EARHART ROAD	ANN ARBOR	MI	48105	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	7	9/9/2020	SUPPLEMENT FOR EXPANSION	$120,210
														Subtotal = $1,120,209

Issue Date FY: 2019 ( Subtotal = $1,000,024 )
2019	2019	ARBOR RESEARCH COLLABORATIVE FOR HEALTH	340 E HURON ST STE 300	ANN ARBOR	MI	48104	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	6	9/5/2019	COMPETING CONTINUATION	$999,999
2019	2019	ARBOR RESEARCH COLLABORATIVE FOR HEALTH	340 E HURON ST STE 300	ANN ARBOR	MI	48104	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	6	9/6/2019	COMPETING CONTINUATION	$25
														Subtotal = $1,000,024

Grand Total All Awards = $5,253,257

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Continuation of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Data Coordinating Center

Award Number: U24DK099879

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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