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dkNET Coordinating Unit: Harnessing the Power of AI and Data Science forCollaborative Discovery and Sharing in the DK Community

Award Number: U24DK097771
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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dkNET Coordinating Unit: Harnessing the Power of AI and Data Science forCollaborative Discovery and Sharing in the DK Community - Project Summary This proposal outlines plans for the next generation NIDDK Information Network (dkNET), whose goal is to provide a centralized resource that connects the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) research community to the growing number of biomedical resources (e.g., organisms, reagents, materials, protocols), data, and bioinformatics tools available to them through the multiple programs and centers established by NIDDK and the broader scientific community. dkNET has seen steady growth over the last project period and achieved significant success toward our mission, highlighted by 4 main areas of impact: 1) provided a novel Resource Information Network (RIN) that connects the NIDDK research community to the expanding universe of biomedical resources and data; 2) significantly improved the rigor and reproducibility of published research through its leadership in creating and promoting adoption of Research Resource Identifiers (RRIDs); 3) increased computational skills among the NIDDK workforce through educational programs, the dkNET Bioinformatics Pilot program, the Hypothesis Center, and the D-Challenge; and 4) brought FAIR (Findable, Accessible, Interoperable, Re-usable) data principles to DK researchers through educational materials, a webinar series, and the Summer of Data student program. dkNET tools, resources, and training materials assist researchers throughout the experimental process from hypothesis generation to supporting sound and reproducible science. Building on the success of dkNET (Resource Core) we will extend its services to the community through a new Computational Core that will bring powerful new AI/ML techniques and cloud computing resources to the NIDDK research community to fully leverage data assets cataloged by dkNET to explore and develop hypotheses. Our objective is to create a unified ML paradigm for performing a diverse range of analytical tasks. This paradigm will have the ability to process the various data types cataloged by dkNET; integrate data of multiple modalities from different sources; and incorporate domain-specific knowledge from public knowledge bases. The resulting knowledge model from this paradigm will facilitate hypothesis validation and recommendation by locating data that supports or contradicts a hypothesis/task and evaluating a given hypothesis’s likelihood.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,000,000 )
2025	2025	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	12	4/17/2025	NON-COMPETING CONTINUATION	$2,000,000
2025	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	11	2/13/2025	COMPETING CONTINUATION	$353,965
2025	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	2/13/2025	SUPPLEMENT FOR EXPANSION	-$353,965
														Subtotal = $2,000,000

Issue Date FY: 2024 ( Subtotal = $2,749,999 )
2024	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	11	7/23/2024	SUPPLEMENT FOR EXPANSION	$749,999
2024	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	11	2/23/2024	COMPETING CONTINUATION	$2,000,000
2024	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	2/15/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,749,999

Issue Date FY: 2023 ( Subtotal = $690,000 )
2023	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	10	6/8/2023	SUPPLEMENT FOR EXPANSION	$690,000
2023	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	1/31/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $690,000

Issue Date FY: 2022 ( Subtotal = $1,730,811 )
2022	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	9	1/7/2022	SUPPLEMENT FOR EXPANSION	$750,000
2022	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	10	8/26/2022	NON-COMPETING CONTINUATION	$980,811
2022	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	9	10/13/2021	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	9	1/20/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,730,811

Issue Date FY: 2021 ( Subtotal = $980,811 )
2021	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	9	9/3/2021	NON-COMPETING CONTINUATION	$980,811
2021	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	8	5/3/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $980,811

Issue Date FY: 2020 ( Subtotal = $2,970,980 )
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	8	7/23/2020	NON-COMPETING CONTINUATION	$1,970,980
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	8	8/3/2020	SUPPLEMENT FOR EXPANSION	$1,000,000
2020	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	7	5/14/2020	NON-COMPETING CONTINUATION	$0
2020	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	7	7/29/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,970,980

Issue Date FY: 2019 ( Subtotal = $2,970,980 )
2019	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	7	8/21/2019	SUPPLEMENT FOR EXPANSION	$990,000
2019	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	7	6/28/2019	NON-COMPETING CONTINUATION	$980,980
2019	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	7	9/13/2019	SUPPLEMENT FOR EXPANSION	$1,000,000
														Subtotal = $2,970,980

Issue Date FY: 2018 ( Subtotal = $994,730 )
2018	2018	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	6	6/25/2018	COMPETING CONTINUATION	$994,730
2018	2017	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	5	6/19/2018	SUPPLEMENT FOR EXPANSION	$0
2018	2017	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	6/19/2018	NON-COMPETING CONTINUATION	$0
2018	2017	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	5	9/26/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $994,730

Issue Date FY: 2017 ( Subtotal = $819,218 )
2017	2017	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	11/30/2016	NON-COMPETING CONTINUATION	$467,365
2017	2017	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	5	6/15/2017	NON-COMPETING CONTINUATION	$51,928
2017	2017	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	5	1/13/2017	SUPPLEMENT FOR EXPANSION	$299,925
														Subtotal = $819,218

Issue Date FY: 2016 ( Subtotal = $522,716 )
2016	2016	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	2/2/2016	EXTENSION WITH OR WITHOUT FUNDS	$522,716
														Subtotal = $522,716

Issue Date FY: 2015 ( Subtotal = $537,174 )
2015	2015	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	3	2/12/2015	NON-COMPETING CONTINUATION	$53,717
2015	2015	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	11/26/2014	NON-COMPETING CONTINUATION	$483,457
														Subtotal = $537,174

Issue Date FY: 2014 ( Subtotal = $563,089 )
2014	2014	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	3/5/2014	NON-COMPETING CONTINUATION	$56,309
2014	2014	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	12/19/2013	NON-COMPETING CONTINUATION	$506,780
														Subtotal = $563,089

Issue Date FY: 2013 ( Subtotal = $600,000 )
2013	2013	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	11/6/2012	NEW	$600,000
														Subtotal = $600,000

Grand Total All Awards = $18,130,508

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dkNET Coordinating Unit: Harnessing the Power of AI and Data Science forCollaborative Discovery and Sharing in the DK Community

Award Number: U24DK097771

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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