Friday, May 9, 2025 5/9/2025

ABCD-USA Consortium: Coordinating Center

Award Number: U24DA041147
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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ABCD-USA Consortium: Coordinating Center - PROJECT SUMMARY In its initial funding period, the ABCD consortium used a rigorous epidemiological approach to recruit a diverse sample of 11,878 9- to 10-year-olds through our 21 research sites, of which 2,136 are twins or triplets. Expert workgroups (WGs) designed protocols using proven methods to assess, scan, and maintain this cohort with very high retention rates. The study complements well validated standardized assessments with novel real-time objective data collected wirelessly in the natural environment to securely capture indices of youth behaviors. These technologies add measurement precision, ecological validity, and an opportunity to reveal previously unknown effects of behavioral, physiological, and environmental factors in the development and fluctuation of substance use, screen media use, mental and physical health concerns, brain development, and their dynamic relationships. Bioassays (e.g., from hair, shed teeth, blood, and oral fluid) provide genome-wide genotyping, pubertal hormones, more precise estimates of exposures to substances of abuse and environmental toxins, and eventually more comprehensive estimates of relevant epigenetic effects. State-of-the-art harmonization methods for MRI and other data enable seamless data integration across sites into an invaluable open-science database that becomes available to the larger scientific community within a year of data collection. The Coordinating Center (CC) met all of its previous aims, and here describes how it will achieve an adjusted set of aims for the next 7 years. Specifically, we describe a flexible organizational framework created for management of the study that relies heavily on cross-disciplinary knowledge and extensive research experience of expert assessment WGs and strategic planning groups, and a dedicated team within the CC, Data Analysis, Informatics and Resource Center (DAIRC), and NIH to coordinate internal and external communications; support and integrate the development and revision of protocols and data quality reviews performed by WGs; establish, monitor, and maintain the standardization of study protocols across the consortium sites; measure and review study progress toward goals for retention, data quality, and scientific impact; based on these metrics, take supportive and corrective action to ensure that the goals are met; manage bioethics policies and consortium interactions with the single IRB (sIRB); promote the professional development of diverse junior investigators; establish a framework to resolve conflicts within the CC or within the wider consortium; and responsibly address any unanticipated scientific, methodological, logistical, or ethical challenges to ensure the study achieves its overarching objectives. We also describe how the CC and DAIRC will together implement quality control procedures to improve data quality across all data types; coordinate data sharing functions with the staff of the NIMH Data Archive; manage a pipeline for enhancing the study with novel assessment technologies; and facilitate rigorous analyses of ABCD data that set new standards for use of data from this powerful, but complex and challenging, high-dimensional study.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $3,560,221 )
2025	2025	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	001	11	4/18/2025	NON-COMPETING CONTINUATION	$0
2025	2025	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	000	11	4/11/2025	NON-COMPETING CONTINUATION	$3,560,221
														Subtotal = $3,560,221

Issue Date FY: 2024 ( Subtotal = $3,954,817 )
2024	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	004	10	8/22/2024	NON-COMPETING CONTINUATION	$0
2024	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	001	10	5/30/2024	NON-COMPETING CONTINUATION	$200,000
2024	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	000	10	4/23/2024	NON-COMPETING CONTINUATION	$3,364,670
2024	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	002	10	7/17/2024	NON-COMPETING CONTINUATION	$0
2024	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	003	10	7/25/2024	NON-COMPETING CONTINUATION	$390,147
2024	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	005	9	9/13/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,954,817

Issue Date FY: 2023 ( Subtotal = $4,342,176 )
2023	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	005	9	4/10/2023	SUPPLEMENT FOR EXPANSION	$200,000
2023	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	004	9	4/7/2023	SUPPLEMENT FOR EXPANSION	$200,000
2023	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	003	9	3/30/2023	NON-COMPETING CONTINUATION	$3,179,748
2023	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	007	9	6/28/2023	NON-COMPETING CONTINUATION	$0
2023	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	008	9	6/30/2023	SUPPLEMENT FOR EXPANSION	$765,000
2023	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	001	8	1/26/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	006	5	5/8/2023	NON-COMPETING CONTINUATION	$0
2023	2018	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	000	4	12/16/2022	NON-COMPETING CONTINUATION	$0
2023	2018	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	002	4	2/2/2023	NON-COMPETING CONTINUATION	-$2,572
														Subtotal = $4,342,176

Issue Date FY: 2022 ( Subtotal = $4,144,035 )
2022	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	004	8	8/29/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	001	8	5/6/2022	SUPPLEMENT FOR EXPANSION	$200,000
2022	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	002	8	5/16/2022	SUPPLEMENT FOR EXPANSION	$400,000
2022	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	003	8	5/23/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	000	8	3/24/2022	NON-COMPETING CONTINUATION	$3,544,035
														Subtotal = $4,144,035

Issue Date FY: 2021 ( Subtotal = $4,559,103 )
2021	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	009	7	7/1/2021	SUPPLEMENT FOR EXPANSION	$200,000
2021	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	006	7	4/15/2021	NON-COMPETING CONTINUATION	$3,705,028
2021	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	011	7	9/16/2021	NON-COMPETING CONTINUATION	$0
2021	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	008	7	6/4/2021	SUPPLEMENT FOR EXPANSION	$654,075
2021	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	010	7	9/15/2021	NON-COMPETING CONTINUATION	$0
2021	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	001	6	12/21/2020	COMPETING CONTINUATION	$0
2021	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	007	6	5/5/2021	COMPETING CONTINUATION	$4,051,162
2021	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	000	6	12/14/2020	COMPETING CONTINUATION	$0
2021	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	002	5	4/13/2021	NON-COMPETING CONTINUATION	-$2,874,097
2021	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	005	4	4/13/2021	SUPPLEMENT FOR EXPANSION	-$250,000
2021	2018	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	004	4	4/13/2021	SUPPLEMENT FOR EXPANSION	-$601,121
2021	2018	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	003	4	4/13/2021	SUPPLEMENT FOR EXPANSION	-$325,944
														Subtotal = $4,559,103

Issue Date FY: 2020 ( Subtotal = $5,122,833 )
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	006	6	8/18/2020	SUPPLEMENT FOR EXPANSION	$650,000
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	002	6	4/14/2020	COMPETING CONTINUATION	$2,818,830
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	008	6	9/15/2020	SUPPLEMENT FOR EXPANSION	$157,487
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	003	6	6/3/2020	SUPPLEMENT FOR EXPANSION	$471,517
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	007	6	8/21/2020	COMPETING CONTINUATION	$0
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	005	6	8/17/2020	SUPPLEMENT FOR EXPANSION	$825,000
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	004	6	7/2/2020	SUPPLEMENT FOR EXPANSION	$199,999
2020	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	001	5	4/13/2020	NON-COMPETING CONTINUATION	$0
2020	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Drug Use and Addiction Research Programs	000	5	2/21/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $5,122,833

Issue Date FY: 2019 ( Subtotal = $3,124,097 ) (Continued on the next page)
Grand Total All Awards = $41,676,003

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ABCD-USA Consortium: Coordinating Center

Award Number: U24DA041147

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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