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Enabling functional multimodal characterization of cancer evolution from single-cell data

Award Number: U24CA294136
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/08/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2031

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Enabling functional multimodal characterization of cancer evolution from single-cell data - Project Summary/Abstract Single-cell molecular profiling technologies have transformed cancer research and medicine. But substantial limitations remain in achieving comprehensive genomic characterization for nucleotide resolution clonal lineage tracing, as well as multiomics for functional interpretation. In this proposal, we propose to develop a toolkit named MEVO (single-cell functional multiomics for cancer evolution) to bridge this gap in informatics technology for cancer research. MEVO will be developed based on high impact algorithms such as Monopogen, Monovar, CopyKAT, CellTrek, bi-CCA and SCMER developed by Chen and Navin lab over the past decade, for comprehensive single-cell genomic characterization, multiomic data integration and functional interpretation. The algorithms will be unified and integrated into an optimized, robust and versatile software package aimed for wide application/adaption, with enhanced functionalities and extended support to emerging technologies including spatial and long read sequencing. The software package will be made open source and released to run on individual computers, computing clusters, or in cloud computing environments. Extensive documentation and training will be provided to facilitate use by a wide range of users from expert bioinformaticians to clinicians. MEVO will accelerate and enhance cancer research by enabling researchers to characterize genetic, non-genetic and phenotypical cellular heterogeneity and evolution within tumors and their microenvironments, that will impact diagnosis and treatment of cancer patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $813,295 )
2026	2026	THE UNIVERISTY OF TEXAS M.D. ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Cancer Biology Research	000	1	9/7/2026	NEW	$813,295
														Subtotal = $813,295

Grand Total All Awards = $813,295

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Enabling functional multimodal characterization of cancer evolution from single-cell data

Award Number: U24CA294136

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/08/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2031

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