Wednesday, September 17, 2025 9/17/2025

Coordinating and Data Management Center for Acquired Resistance to Therapy Network

Award Number: U24CA274159
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2022
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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Coordinating and Data Management Center for Acquired Resistance to Therapy Network - Project Summary The goal of our proposed Coordinating and Data Management Center (CDMC) application is to coordinate the activities across the Acquired Resistance to Therapy Network (ARTNet), and to manage, integrate and disseminate the data and resources generated through the network. Leveraging cutting-edge multi-disciplinary team approaches, we will support the ARTNet to inform new strategies that can be better translated to overcome significant challenges in acquired resistance to cancer therapies. Our strategy is to enhance the productivity of ARTNet investigators by fostering a collaborative and supportive research community, accelerate the progress of ARTNet research by reducing barriers to accessing analytical expertise, ensure the reproducibility of ARTNet data by deploying best practices for data acquisition and harmonization, and unleash the full potential of ARTNet activities by developing enhanced tools to enable resource sharing to the broader scientific community. First, we will provide a centralized administrative infrastructure to coordinate ARTNet activities, building upon our well-functioning infrastructure that currently coordinates network studies under the umbrella of the NCI Cancer Moonshot initiatives. Second, we will actively promote the ARTNet and engage in trans-consortium interactions, where we will leverage our demonstrable experience in Cross-Moonshot outreach and Bioconductor’s decades-long record in community engagement. Third, we will provide multidisciplinary analytical expertise to support ARTNet collaborative research, leveraging five of Roswell Park CCSG’s shared resources: Biostatistics, Bioinformatics, Biomedical Informatics, Pharmacokinetics/Pharmacodynamics, and Data Bank and BioRepository. Our analytical support will be provided at no cost to ARTNet investigators in need of analytical expertise, based on collaboration, transparency, and sharing. Fourth, we will develop improved data integration software and workflows to enhance ARTNet’s research capacity, capitalizing on our extensive track-record in developing NIH-supported Moonshot, Bioconductor and AnVIL ecosystems. The main deliverables from the proposed aims will be administrative and outreach support to coordinate network activities, facilitate network collaboration, and engage in interaction with the broader community (Aim 1); polices and infrastructures to ensure that all resources generated by the ARTNet will be findable in a centralized virtual resource sharing repository, and that all resources will be shared with the broader scientific community (Aim 2); workflows to ensure that all data generated by the ARTNet will be harmonized using standards interoperable with the broader cancer data ecosystem, analysis tools to integrate ARTNet data and facilitate cross-study analysis within and beyond the ARTNet, and multidisciplinary analytical supports to accelerate ARTNet research progress.(Aim 3).


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,907,138 )
2025	2025	HEALTH RESEARCH, INC.	665 ELM ST	BUFFALO	NY	14203	ERIE	USA	Cancer Treatment Research	000	3	4/3/2025	SUPPLEMENT FOR EXPANSION	$74,605
2025	2025	HEALTH RESEARCH, INC.	665 ELM ST	BUFFALO	NY	14203	ERIE	USA	Cancer Treatment Research	001	4	9/10/2025	NON-COMPETING CONTINUATION	$1,832,533
														Subtotal = $1,907,138

Issue Date FY: 2024 ( Subtotal = $1,745,001 )
2024	2024	HEALTH RESEARCH, INC.	665 ELM ST	BUFFALO	NY	14203	ERIE	USA	Cancer Treatment Research	007	3	9/25/2024	NON-COMPETING CONTINUATION	$0
2024	2024	HEALTH RESEARCH, INC.	665 ELM ST	BUFFALO	NY	14203	ERIE	USA	Cancer Centers Support Grants	003	3	8/31/2024	SUPPLEMENT FOR EXPANSION	$758,183
2024	2024	HEALTH RESEARCH, INC.	665 ELM ST	BUFFALO	NY	14203	ERIE	USA	Cancer Centers Support Grants	005	3	9/6/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2024	HEALTH RESEARCH, INC.	665 ELM ST	BUFFALO	NY	14203	ERIE	USA	Cancer Treatment Research	004	3	9/6/2024	NON-COMPETING CONTINUATION	-$758,183
2024	2024	HEALTH RESEARCH, INC.	665 ELM ST	BUFFALO	NY	14203	ERIE	USA	Cancer Treatment Research	006	3	9/17/2024	NON-COMPETING CONTINUATION	$0
2024	2024	HEALTH RESEARCH, INC.	665 ELM ST	BUFFALO	NY	14203	ERIE	USA	Cancer Treatment Research	002	3	8/29/2024	NON-COMPETING CONTINUATION	$1,745,001
2024	2023	HEALTH RESEARCH, INC.	ELM & CARLTON ST	BUFFALO	NY	14263	ERIE	USA	Cancer Treatment Research	000	2	1/10/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2023	HEALTH RESEARCH, INC.	665 ELM ST	BUFFALO	NY	14203	ERIE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	001	2	7/1/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,745,001

Issue Date FY: 2023 ( Subtotal = $1,881,790 )
2023	2023	HEALTH RESEARCH, INC.	ELM & CARLTON ST	BUFFALO	NY	14263	ERIE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	000	2	8/21/2023	NON-COMPETING CONTINUATION	$1,024,775
2023	2023	HEALTH RESEARCH, INC.	ELM & CARLTON ST	BUFFALO	NY	14263	ERIE	USA	Cancer Treatment Research	001	2	9/14/2023	SUPPLEMENT FOR EXPANSION	$771,165
2023	2023	HEALTH RESEARCH, INC.	ELM & CARLTON ST	BUFFALO	NY	14263	ERIE	USA	Cancer Treatment Research	002	2	9/18/2023	SUPPLEMENT FOR EXPANSION	$85,850
														Subtotal = $1,881,790

Issue Date FY: 2022 ( Subtotal = $1,050,404 )
2022	2022	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	000	1	8/11/2022	NEW	$1,050,404
														Subtotal = $1,050,404

Grand Total All Awards = $6,584,333

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Coordinating and Data Management Center for Acquired Resistance to Therapy Network

Award Number: U24CA274159

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2022

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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