Thursday, April 25, 2024
4/25/2024
Project Summary/Abstract: This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA-23-012. The goal of our proposed Data and Resource Coordinating Center (DRCC) application is to coordinate the activities across the Cancer Prevention-Interception Targeted Agent Discovery Program (CAP-IT), and to manage, integrate and disseminate the data and resources generated through the network. Leveraging cutting-edge multi-disciplinary team approaches, we will support the CAP-IT to discover molecularly or immunologically targeted agents designed to prevent or intercept the oncogenic process for precision cancer prevention and interception. Our strategy is to enhance the productivity of CAP-IT investigators by fostering a collaborative and synergistic research community, accelerate the progress of CAP- IT research by reducing barriers to accessing analytics expertise, ensure the reproducibility of CAP-IT data by deploying best practices for data acquisition and harmonization, and unleash the full potential of CAP-IT activities by developing enhanced tools to enable resource sharing to the broader scientific community. First, we will provide a centralized administrative infrastructure to coordinate CAP-IT activities, building upon our well-functioning infrastructure that currently coordinates network studies under the umbrella of the NCI Cancer Moonshot initiatives. Second, we will actively promote the CAP-IT and engage in trans-consortium interactions, where we will leverage our demonstrable experience in Cross-Moonshot outreach and Bioconductor’s decades-long record in community engagement. Third, we will, in coordination with each CAP- IT center’s informatics group, provide multidisciplinary analytics expertise to support CAP-IT’s collaborative research, leveraging three of Roswell Park CCSG’s shared resources: Biostatistics, Bioinformatics, Biomedical Informatics. Fourth, we will develop improved data integration and analysis software, database and workflows to enhance CAP-IT’s research capacity, capitalizing on our extensive track-record in developing NIH-supported Cancer Moonshot, Bioconductor and AnVIL ecosystems. Taken together, we envision that our DRCC, in close collaboration with the CAP-IT U54 Centers and NCI staffs, will allow us to support highly effective and innovative translational studies to address the significantly unmet needs related to precision cancer prevention-interception. The main deliverables from the proposed aims will be administrative and outreach support to coordinate network activities, facilitate network collaboration, and engage in interaction with the broader community (Aim 1); workflows to ensure that all data generated by the CAP-IT will be harmonized using standards interoperable with the broader cancer data ecosystem, analysis tools and database to integrate CAP-IT data and facilitate cross-study analysis, and multidisciplinary analytics supports to accelerate CAP-IT research progress (Aim 2); polices and infrastructures to ensure that all resources generated by the CAP-IT will be findable in a centralized virtual information hub, and that all resources will be shared with the broader scientific community (Aim 3).
HHS’ Tracking Accountability in Government Grants System (TAGGS) website provides access to detailed descriptions of grants, loans, aggregated direct payments and other types of financial assistance awarded by the HHS Operating Divisions (OPDIVs) and the Office of the Secretary Staff Divisions (STAFFDIVs).
