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Center for comprehensive proteogenomic data analysis

Award Number: U24CA271075
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/15/2022
PERIOD OF PERFORMANCE END DATE: 05/31/2027

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Center for comprehensive proteogenomic data analysis - Project Summary Proteogenomics involves the integrative multi-omic analysis of genomic, transcriptomic, proteomic and post- translational modification data produced by next-generation sequencing and mass spectrometry-based proteomics. Several publications by the Clinical Proteomic Tumor Analysis Consortium (CPTAC) and others have highlighted the impact of proteogenomics in enabling deeper insight into the biology of cancer and identification of potential drug targets. Integrative analysis of multi-omic data requires the deployment of complex algorithms and data processing techniques, which are generally inaccessible to scientists without a background in bioinformatics and computational biology. Our proposed center for comprehensive proteogenomic data analysis will encapsulate a comprehensive set of analysis methods in a platform that will be (i) simple to use (ii) flexible (iii) automated, facilitating the routine application to all CPTAC proteogenomic datasets as they become available, and (iv) able to incorporate new methods with minimal effort. We will leverage PANOPLY--a cloud-based platform for automated and reproducible proteogenomic data analysis--as the foundation, with specific, carefully chosen algorithms targeted for addition to provide an expansive set of analysis capabilities that can be easily harnessed to provide a rapid and extensive baseline analysis for proteogenomic studies, leading to many disease specific hypotheses that can be explored further using additional computational and wet-lab experiments. Our collection of tools, algorithms and interactive reports will enable unprecedented, automated and integrative systems-biology level analyses of proteome, post-translational modification and metabolomic data combined with genomic data for individual disease cohorts and pan-cancer analysis across cohorts, leading to deeper understanding of cancer biology and enabling identification of therapeutic targets and disease/prognostic biomarkers.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $788,387 )
2026	2026	THE BROAD INSTITUTE, INC	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Cancer Detection and Diagnosis Research	000	5	6/25/2026	NON-COMPETING CONTINUATION	$788,387
														Subtotal = $788,387

Issue Date FY: 2025 ( Subtotal = $791,128 )
2025	2025	THE BROAD INSTITUTE, INC	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Cancer Detection and Diagnosis Research	001	4	5/30/2025	NON-COMPETING CONTINUATION	$791,128
2025	2024	THE BROAD INSTITUTE, INC	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Cancer Detection and Diagnosis Research	000	3	1/6/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $791,128

Issue Date FY: 2024 ( Subtotal = $751,571 )
2024	2024	THE BROAD INSTITUTE, INC	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Cancer Detection and Diagnosis Research	000	3	6/25/2024	NON-COMPETING CONTINUATION	$751,571
														Subtotal = $751,571

Issue Date FY: 2023 ( Subtotal = $775,306 )
2023	2023	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Cancer Detection and Diagnosis Research	000	2	7/6/2023	NON-COMPETING CONTINUATION	$775,306
														Subtotal = $775,306

Issue Date FY: 2022 ( Subtotal = $791,128 )
2022	2022	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Cancer Detection and Diagnosis Research	001	1	7/14/2022	NEW	$0
2022	2022	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Cancer Detection and Diagnosis Research	000	1	6/13/2022	NEW	$791,128
														Subtotal = $791,128

Grand Total All Awards = $3,897,520

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Center for comprehensive proteogenomic data analysis

Award Number: U24CA271075

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/15/2022

PERIOD OF PERFORMANCE END DATE: 05/31/2027

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