Monday, February 16, 2026 2/16/2026

Immuno-Oncology Translation Network: Data Management and Resource-Sharing Center at RPCI

Award Number: U24CA232979
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2018
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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Immuno-Oncology Translation Network: Data Management and Resource-Sharing Center at RPCI - Project Summary While several innovative and creative immuno-oncology (IO) strategies have shown promising results, a significant expansion of their clinical use will require collaborative efforts to elucidate the resistance mechanism, discover new immune targets, identify predictive biomarkers, evaluate combination therapies, and develop preventive approaches. Utilizing a multi-disciplinary team approach, we will support Immuno-Oncology Translation Network (IOTN)-funded components to discover new immune targets and evaluate novel immune- based therapies and combination approaches that eliminate established cancers in adults or to prevent cancers before they occur. Our DMRC strategy is to serve as an administrative and analytic hub at every step of the IOTN's translational studies, focusing to reduce the barrier for access to analytic expertise, improve the productivity of IOTN investigators, maintain a high standard for data collection and management, design and perform rigorous analytical strategies, and foster a collaborative and supportive research community. An experienced, multidisciplinary team has been assembled to pursue four specific aims: First, we will provide a centralized administration infrastructure to coordinate IOTN activities, building upon the NRG Oncology Statistical and Data Coordinating Center's experience of coordinating over 450 translational cancer studies across hundreds of participating sites. Second, we will provide multidisciplinary analytic expertise to support IOTN collaborative research, leveraging five of RPCI CCSG's shared resources: Biostatistics, Bioinformatics, Biomedical Data Science, Data Bank and BioRepository, and Immune Analysis. Our analytic support will be armed with professional IT staff and informed by an experienced IO researcher team. Third, we will develop innovative data integration methods to enhance IOTN research capacity, capitalizing on the well-respected Bioconductor project and the independent research programs of the RPCI department of Biostatistics and Bioinformatics. Fourth, we will actively promote the IOTN and engage in trans-consortium interactions, where we will leverage Bioconductor's decade-long experience in community engagement and the NRG data center's rich expertise in project coordination. Leveraging our active NCI-funded RPCI-committed resource to support the proposed multi-institutional trans-disciplinary IO research is not only cost-effective, but also flexible in its study-dependent scalability. Taken together, we envision that our DMRC, in close collaboration with the IOTN, will allow us to conduct highly effective and innovative translational studies to address the significantly unmet clinical needs related to IO.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$147,386 )
2026	2018	HEALTH RESEARCH, INC.	665 ELM ST	BUFFALO	NY	14203	ERIE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	000	1	1/21/2026	NEW	-$147,386
														Subtotal = -$147,386

Issue Date FY: 2024 ( Subtotal = $102,886 )
2024	2024	HEALTH RESEARCH, INC.	665 ELM ST	BUFFALO	NY	14203	ERIE	USA	Cancer Biology Research	012	1	9/9/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2024	HEALTH RESEARCH, INC.	665 ELM ST	BUFFALO	NY	14203	ERIE	USA	Cancer Biology Research	000	1	1/29/2024	SUPPLEMENT FOR EXPANSION	$102,886
2024	2023	HEALTH RESEARCH, INC.	665 ELM ST	BUFFALO	NY	14203	ERIE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	011	1	9/5/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2023	HEALTH RESEARCH, INC.	665 ELM ST	BUFFALO	NY	14203	ERIE	USA	Cancer Biology Research	010	1	9/4/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2022	HEALTH RESEARCH, INC.	665 ELM ST	BUFFALO	NY	14203	ERIE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	008	1	8/19/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2021	HEALTH RESEARCH, INC.	665 ELM ST	BUFFALO	NY	14203	ERIE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	007	1	8/16/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2021	HEALTH RESEARCH, INC.	665 ELM ST	BUFFALO	NY	14203	ERIE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	006	1	8/14/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2020	HEALTH RESEARCH, INC.	665 ELM ST	BUFFALO	NY	14203	ERIE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	002	1	8/8/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2020	HEALTH RESEARCH, INC.	665 ELM ST	BUFFALO	NY	14203	ERIE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	005	1	8/13/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2020	HEALTH RESEARCH, INC.	665 ELM ST	BUFFALO	NY	14203	ERIE	USA	Cancer Biology Research	004	1	8/9/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2019	HEALTH RESEARCH, INC.	665 ELM ST	BUFFALO	NY	14203	ERIE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	003	1	8/9/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2018	HEALTH RESEARCH, INC.	665 ELM ST	BUFFALO	NY	14203	ERIE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	001	1	8/2/2024	NEW	$0
2024	2018	HEALTH RESEARCH, INC.	665 ELM ST	BUFFALO	NY	14203	ERIE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	009	1	8/28/2024	NEW	$0
														Subtotal = $102,886

Issue Date FY: 2023 ( Subtotal = $459,775 )
2023	2023	HEALTH RESEARCH, INC.	ELM & CARLTON ST	BUFFALO	NY	14263	ERIE	USA	Cancer Biology Research	000	1	4/14/2023	SUPPLEMENT FOR EXPANSION	$26,025
2023	2023	HEALTH RESEARCH, INC.	ELM & CARLTON ST	BUFFALO	NY	14263	ERIE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	002	1	7/14/2023	SUPPLEMENT FOR EXPANSION	$433,750
2023	2018	HEALTH RESEARCH, INC.	ELM & CARLTON ST	BUFFALO	NY	14263	ERIE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	001	1	6/16/2023	NEW	$0
														Subtotal = $459,775

Issue Date FY: 2022 ( Subtotal = $105,545 )
2022	2022	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	001	1	5/25/2022	SUPPLEMENT FOR EXPANSION	$105,545
2022	2020	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	Cancer Biology Research	000	1	12/30/2021	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $105,545

Issue Date FY: 2021 ( Subtotal = $940,743 )
2021	2021	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	002	1	9/21/2021	SUPPLEMENT FOR EXPANSION	$99,743
2021	2021	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	001	1	7/29/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2021	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	000	1	5/17/2021	SUPPLEMENT FOR EXPANSION	$841,000
														Subtotal = $940,743

Issue Date FY: 2020 ( Subtotal = $955,337 )
2020	2020	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	Cancer Biology Research	003	1	9/2/2020	SUPPLEMENT FOR EXPANSION	$74,055
2020	2020	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	004	1	9/11/2020	SUPPLEMENT FOR EXPANSION	$841,000
2020	2020	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	001	1	1/31/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2020	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	000	1	1/7/2020	SUPPLEMENT FOR EXPANSION	$40,282
2020	2018	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	002	1	4/23/2020	NEW	$0
														Subtotal = $955,337

Issue Date FY: 2019 ( Subtotal = $71,119 )
2019	2019	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	000	1	6/5/2019	SUPPLEMENT FOR EXPANSION	$71,119
														Subtotal = $71,119

Issue Date FY: 2018 ( Subtotal = $6,276,836 )
2018	2018	HEALTH RESEARCH, INC.	ELM AND CARLTON ST	BUFFALO	NY	14263	ERIE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	000	1	9/20/2018	NEW	$6,276,836
														Subtotal = $6,276,836

Grand Total All Awards = $8,764,855

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Immuno-Oncology Translation Network: Data Management and Resource-Sharing Center at RPCI

Award Number: U24CA232979

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2018

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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