Sunday, February 15, 2026 2/15/2026

Cancer Immunologic Data Commons (CIDC) Supplement Request

Award Number: U24CA224316
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2017
PERIOD OF PERFORMANCE END DATE: 06/30/2023

Group Awards By:

View Award Description

Cancer Immunologic Data Commons (CIDC) Supplement Request - ABSTRACT Cancer immunotherapies have emerged as highly promising approaches to treat cancer patients, particularly since they can be applied across different tissue and cancer types, although clinical efficacy has been limited to a subset of cancer patients1. Translational studies with strong focus on biomarkers are critical to understanding the tumor-immune interface. Although numerous technologies for tumor and immune profiling are applied to NCI sponsored immunotherapy trials, standardization of both assay protocols and data analysis methods is crucial to data integration and comparisons across studies for biomarker identification2. This underlines the need for data harmonization and creation of uniform analysis pipelines. We propose to continue development of the Cancer Immunology Data Commons (CIDC) at the Dana-Farber Cancer Institute with the goal of advancing translational research efforts using biomarkers to aid in the further development of cancer immunotherapy. The short-term objectives of this application are to establish and manage the data repository for biomarkers and associated clinical data for Cancer Immune Monitoring and Analysis Centers (CIMACs), and provide an informatics environment for integrative multidimensional analysis across different studies and storage of data generated. Specifically, we propose to: Aim 1, coordinate with the CIMAC and Laboratory Coordinating Committee (LCC) to harmonize establish assay protocols and data format standards; Aim 2, develop a centralized data repository and management system, and coordinate CIMAC data submission to the CIDC; Aim 3, develop uniform bioinformatics processing pipelines and computing infrastructure for computationally intensive analyses for the CIMACs and the larger research community; Aim 4, provide bioinformatics algorithms to enable integrative and correlative analysis of CIMAC data and integrate other accessible databases and resources for biomarker discovery; Aim 5, develop centralized role-based data access functions with advanced programming interface to enable sharing of CIMAC data; Aim 6, develop interactive web visualization functions to enable investigators and the immunology communities to examine the CIMAC data; and Aim 7, coordinate within the CIMACs-CIDC Network logistic and scientific activities for biomarker discovery and validation. At the conclusion, we will have established a biomarker repository for all data and results generated by CIMACs, supplemented with standardized informatics tools for integration with other accessible databases, and compatible for data contribution and secondary analyses by external researchers. These efforts will provide bioinformatics support for the CIMACs-CIDC Network. The established Data Commons will also provide the foundation for a future immuno-oncology data resource for the larger research community.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02215	SUFFOLK	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	000	1	1/12/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $1,000,000 )
2022	2022	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	001	1	9/13/2022	SUPPLEMENT FOR EXPANSION	$1,000,000
2022	2017	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	000	1	10/18/2021	NEW	$0
														Subtotal = $1,000,000

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2017	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	001	1	3/19/2021	NEW	$0
2021	2017	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	000	1	2/5/2021	NEW	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $5,785,000 )
2017	2017	DANA-FARBER CANCER INSTITUTE, INC.	450 BROOKLINE AVE	BOSTON	MA	02115	SUFFOLK	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	000	1	9/25/2017	NEW	$5,785,000
														Subtotal = $5,785,000

Grand Total All Awards = $6,785,000

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Cancer Immunologic Data Commons (CIDC) Supplement Request

Award Number: U24CA224316

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2017

PERIOD OF PERFORMANCE END DATE: 06/30/2023

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer