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Back Pain Consortium (BACPAC) Research Program Data Integration, Algorithm Development and Operations Management Center

Award Number: U24AR076730
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/26/2019
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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Back Pain Consortium (BACPAC) Research Program Data Integration, Algorithm Development and Operations Management Center - ABSTRACT The goal of this U24 application is to establish the Data Integration, Algorithm Development and Operations Management Center (DAC) for NIAMS' Back Pain Consortium (BACPAC) Research Program to ensure that the research objectives are met. The objectives of BACPAC include (i) discovery of lower back pain mechanisms through expert application of clinical and translational medicine methodologies; (ii) identification of new interventions targeted to individual patients through knowledge of established and newly discovered mechanisms; and (iii) evaluation of promising interventions to determine those that warrant further study, potentially leading to regulatory approval. A successful BACPAC research program will be based on cutting edge technologies and reflect the patient-centric focus that is critical to any investigation in this chronic and burdensome disease. Central to this success will be an innovative, forward-looking, and productive DAC that brings cohesion to research performed by the participating Mechanistic Research Centers, Technology Research Sites, and Phase 2 Clinical Trials Centers. DAC Investigators will share their vision and provide scientific leadership and organizational support to the BACPAC Consortium. Our research plan consists of designing and conducting clinical trials with precision interventions in stratified patient populations. Precision medicine interventions that focus on identifying the best treatments for individual patients, instead of the best treatments for the most patients, could improve overall outcomes among this heterogenous patient population. Key elements of the DAC that will enhance collaboration and research progress include experienced leadership, innovative design and analysis methodologies (e.g., sequential adaptive designs, machine learning, neural networks, Q-learning), comprehensive research operations support, a state-of-the-art data management and integration system, and superior administrative support. Our communications infrastructure will provide both public and private websites and a social media presence to effectively disseminate appropriate information to BACPAC investigators, participants, and the public. We will develop a secure, user- friendly advanced data management and integration system that includes web-based access for surveys, data entry, research management (including comprehensive reporting, biosample tracking and performance-based reimbursement tools), integration with external applications, and quality control. Our research operations and administration teams will provide a solid foundation to the BACPAC Research Program by facilitating meetings, collaborative document preparation, tracking of regulatory compliance, and support for abstract and publication preparation across the BACPAC Consortium. Together, this integrated structure will set the stage for technology assessments, solicitation of patient input and utilities, and the evaluation of high-impact interventions through the innovative design and sound execution of clinical trials, leading to effective personalized treatment approaches for patients with chronic lower back pain.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	2	3/13/2025	EXTENSION WITH OR WITHOUT FUNDS	$0
2025	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	2	10/16/2024	EXTENSION WITH OR WITHOUT FUNDS	$0
2025	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	10/1/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $3,841,208 )
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	007	2	9/12/2024	SUPPLEMENT FOR EXPANSION	$3,841,208
2024	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	003	2	3/18/2024	EXTENSION WITH OR WITHOUT FUNDS	$19,674,935
2024	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	12/4/2023	EXTENSION WITH OR WITHOUT FUNDS	$0
2024	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	005	2	4/15/2024	EXTENSION WITH OR WITHOUT FUNDS	$0
2024	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	006	2	7/29/2024	EXTENSION WITH OR WITHOUT FUNDS	$0
2024	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	004	1	3/18/2024	SUPPLEMENT FOR EXPANSION	-$416,385
2024	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	1	2/29/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	1	3/18/2024	NEW	-$19,258,550
														Subtotal = $3,841,208

Issue Date FY: 2023 ( Subtotal = $4,000,000 )
2023	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	2	9/1/2023	EXTENSION WITH OR WITHOUT FUNDS	$4,000,000
2023	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	003	2	9/27/2023	EXTENSION WITH OR WITHOUT FUNDS	$0
2023	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	2/23/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	1	8/30/2023	NEW	$0
														Subtotal = $4,000,000

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	1	12/10/2021	NEW	$0
2022	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	004	1	9/7/2022	NEW	$0
2022	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	1	11/19/2021	NEW	$0
2022	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	003	1	3/30/2022	NEW	$0
2022	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	10/25/2021	NEW	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $416,385 )
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	003	1	9/17/2021	SUPPLEMENT FOR EXPANSION	$416,385
2021	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	1	6/25/2021	NEW	$0
2021	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	1	8/4/2021	NEW	$0
2021	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	5/24/2021	NEW	$0
														Subtotal = $416,385

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	11/14/2019	NEW	$0
2020	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	1	8/3/2020	NEW	$0
2020	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	1	2/14/2020	NEW	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $51,781,303 )
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	9/26/2019	NEW	$51,781,303
														Subtotal = $51,781,303

Grand Total All Awards = $60,038,896

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Back Pain Consortium (BACPAC) Research Program Data Integration, Algorithm Development and Operations Management Center

Award Number: U24AR076730

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/26/2019

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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