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HIV Pharmacology Data Repository

Award Number: U24AI181685
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/12/2024
PERIOD OF PERFORMANCE END DATE: 12/31/2028

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HIV Pharmacology Data Repository - Abstract HIV Pharmacology Data Repository (HIV PDR) Clinical pharmacology is paramount to developing new therapeutic strategies for HIV treatment, prevention, and cure that are needed to end the epidemic. Since its inception in 2001, the UNC Center for AIDS Research (CFAR) Clinical Pharmacology and Analytical Chemistry (CPAC) Core has led the field in the provision of high- quality clinical pharmacology services to HIV/AIDS researchers. The CPAC Core has consolidated >75,000 unique concentration vs time (CvT) datapoints resulting from >29,000 samples collected across 482 unique studies quantifying 72 drug molecules in 10 species and 14 anatomical compartments into a single searchable data portal - the HIV Pharmacology Data Repository (HIV PDR). Pooled CvT data can be easily extracted from the HIV PDR in machine readable output, making this data portal a valuable informatic tool for sharing and exploring antiretroviral pharmacokinetic data to accelerate biomedical research discovery. We seek to maximize the HIV PDR’s scientific impact by expanding and disseminating this resource through the following aims: 1) creating new tools to catalyze data expansion, 2) demonstrating utility by promoting scientific exploration, and 3) propagating use by engaging users and characterizing their Target Product Profile (TPP). To this end we propose to apply FAIR (Findable, Accessible, Interoperable, Reusable) principles to expand CvT data archives, promote exploration, and empirically inform downstream development of the HIV PDR. We will ensure the long- term sustainability of this valuable resource by creating advisory boards to oversee the development of a robust governance plan designed to ensure regulatory compliance while meeting user needs. Finally, in performing the proposed aims, we will pioneer a data-sharing service to assist HIV/AIDS researchers in meeting the recommendations provided within the 2023 NIH Policy for Data Management and Sharing.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $505,786 )
2026	2026	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Allergy and Infectious Diseases Research	000	3	1/13/2026	NON-COMPETING CONTINUATION	$505,786
														Subtotal = $505,786

Issue Date FY: 2025 ( Subtotal = $497,208 )
2025	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Allergy and Infectious Diseases Research	001	2	12/12/2024	NON-COMPETING CONTINUATION	$497,208
2025	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Allergy and Infectious Diseases Research	000	1	11/15/2024	NEW	$0
														Subtotal = $497,208

Issue Date FY: 2024 ( Subtotal = $530,266 )
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Allergy and Infectious Diseases Research	000	1	1/12/2024	NEW	$530,266
														Subtotal = $530,266

Grand Total All Awards = $1,533,260

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HIV Pharmacology Data Repository

Award Number: U24AI181685

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/12/2024

PERIOD OF PERFORMANCE END DATE: 12/31/2028

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