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ReCARDO: Using Real-World Data to Derive Common Data Elements for Alzheimer's Disease and AD-Related Dementias Research Through Ontological Innovation

Award Number: U24AG098157
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2025
PERIOD OF PERFORMANCE END DATE: 08/31/2030

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ReCARDO: Using Real-World Data to Derive Common Data Elements for Alzheimer's Disease and AD-Related Dementias Research Through Ontological Innovation - Project Summary Common Data Elements (CDEs) are metadata standards serving as a foundation for semantic interoperability, a prerequisite for leveraging disparate Real-World Data (RWD) sources for secondary analysis. Existing efforts in AD-related metadata development include the National Alzheimer’s Coordinating Center’s (NACC) Uniform Data Set and NINDS CDEs. These are parts of an important metadata collection for AD/ADRD research, but existing CDEs are not designed, developed, and sufficiently validated to transform NIA-funded studies through the generation of Real-World Evidence (RWE) from RWD with data linkage and longitudinal analyses. In this U24 project, “ReCARDO: Using Real-World Data to Derive Common Data Elements for Alzheimer’s Disease and AD-Related Dementias Research Through Ontological Innovation,” we propose to create a ten- institution research network for developing an AD/ADRD-focused, collaborative data ecosystem incorporating CDEs to leverage RWD for empowering NIA-funded studies, and for enhancing the transparency, rigor and reproducibility of AD/ADRD research. Our aims cover the development (Aim 1), application (Aim 2), and dissemination (Aim 3) of AD/ADRD CDEs and AI/ML/NLP tools through this national collaborative ReCARDO Research Network (RRN). These aims will be achieved through the organization of the RRN in seven Work Streams: 1. CDE development and CDE knowledge graph; 2. CDE extraction from RWD; 3. Data, metadata, and resource ecosystems; 4. AI/ML/NLP and computational phenotyping; 5. Research questions, use cases, and CDE application, including a pilot study program; 6. Genetics, imaging, biomarkers and big data; and 7. Reproducibility and evaluation. Administrative support (Aim 4) will be provided through five Key Functions: Steering Committee (SC) and External Advisory Panel (EAP); Management and support for Work Streams, annual meeting, and the pilot study program; Innovation capacity development; Governance framework adopting best practices; and Dissemination and outreach activities, including a project Web Portal. This project is significant because it creates an ecosystem approach to addressing data harmonization and reproducibility challenges in maximizing the value of RWD through partnership among ADRCs. This project is innovative because it builds on the latest data science and ontological advances to ensure sustained impact in a federated data ecosystem incorporating AD-CDEs for translating RWD to RWE. Our novel conceptual project framework is designed to bring together teams and ensure the effective operation and impact of the RRN in a milestone-driven, collaborative setting, led by a group of world-class data scientists working side-by-side with some of the most established domain experts in AD/ADRD. Success of ReCARDO will revolutionize our approach to translational data-driven discovery in AD/ADRD research, for decades to come.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $5,804,982 )
2026	2026	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON	7000 FANNIN ST FL 9	HOUSTON	TX	77030	HARRIS	USA	Aging Research	000	2	8/20/2026	NON-COMPETING CONTINUATION	$5,804,982
														Subtotal = $5,804,982

Issue Date FY: 2025 ( Subtotal = $3,995,531 )
2025	2025	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON	7000 FANNIN ST FL 9	HOUSTON	TX	77030	HARRIS	USA	Aging Research	000	1	9/11/2025	NEW	$3,995,531
														Subtotal = $3,995,531

Grand Total All Awards = $9,800,513

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ReCARDO: Using Real-World Data to Derive Common Data Elements for Alzheimer's Disease and AD-Related Dementias Research Through Ontological Innovation

Award Number: U24AG098157

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2025

PERIOD OF PERFORMANCE END DATE: 08/31/2030

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