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Caenorhabditis Testing Program Data Coordinating Center

Award Number: U24AG056052
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/05/2017
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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Caenorhabditis Testing Program Data Coordinating Center - Caenorhabditis Intervention Testing Program Data Coordinating Center—Project Summary Health challenges linked to human aging take a tremendous toll on society. Physical and cognitive decline limit the quality of life for the elderly and their caregivers. Aging is the major risk factor for, and possible cause of, cancer, diabetes, and neurodegenerative disease. Without question, the promotion of healthy aging with extended resistance to decline and disease should be a major objective of current medical research. Fortunately, tremendous progress has been made in the biology of aging field and the science is poised to be translated into preclinical and clinical science. Simple animal models such as the nematode Caenorhabditis elegans have been at the heart of this success. Many genes and chemical compound interventions that modulate aging processes are likely to act similarly in humans. The goal of the proposed work is to continue, and expand, efforts of a co-operative scientific group involving three closely interacting laboratories who coordinately test pharmacological interventions for their ability to extend healthy aging and promote longevity in nematodes. A specific emphasis of this integrated super-group is to test promising compound on a collection of natural variants of the Caenorhabditis genus, which together represent the extensive genetic heterogeneity in the human population. The idea is that treatments that confer positive outcomes across a diverse population will have an increased chance of being effective in humans. The Data Coordinating Center supports work at all three project sites by creating a centralized data repository (currently 400,000 longevity records), uniform analytical pipelines, and public-facing repositories and websites. The emphasis of this specific proposal is to (1) maintain and enhance a central data repository to support the work of all CITP labs, (2) generate standardized open-source analytical framework for all CITP data analysis, (3) develop comprehensive database and analytical framework for novel hallmarks of aging and healthspan, and (4) develop a public and private online portal of lifespan and healthspan data. Overall, we will participate in a unique team project that has the power to define pharmacological interventions that robustly promote strong healthspan across a varied population, with implications for development of therapies that promote healthy human aging.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $290,301 )
2025	2025	UNIVERSITY OF OREGON	1776 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	001	10	7/23/2025	NON-COMPETING CONTINUATION	$290,301
2025	2024	UNIVERSITY OF OREGON	1776 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	000	9	7/16/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $290,301

Issue Date FY: 2024 ( Subtotal = $290,301 )
2024	2024	UNIVERSITY OF OREGON	1776 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	001	9	8/13/2024	NON-COMPETING CONTINUATION	$290,301
2024	2022	UNIVERSITY OF OREGON	1776 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	000	7	4/4/2024	COMPETING CONTINUATION	$0
														Subtotal = $290,301

Issue Date FY: 2023 ( Subtotal = $290,301 )
2023	2023	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	002	8	7/7/2023	NON-COMPETING CONTINUATION	$290,301
2023	2022	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	000	7	6/8/2023	COMPETING CONTINUATION	$92,339
2023	2022	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	001	6	6/8/2023	SUPPLEMENT FOR EXPANSION	-$92,339
														Subtotal = $290,301

Issue Date FY: 2022 ( Subtotal = $415,208 )
2022	2022	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	000	6	6/15/2022	SUPPLEMENT FOR EXPANSION	$124,907
2022	2022	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	004	7	7/22/2022	COMPETING CONTINUATION	$290,301
2022	2022	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	003	6	7/21/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2021	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	002	6	7/21/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2021	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	001	6	7/21/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $415,208

Issue Date FY: 2021 ( Subtotal = $195,412 )
2021	2021	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	000	6	3/19/2021	NON-COMPETING CONTINUATION	$102,642
2021	2021	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	002	6	8/31/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2021	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	003	6	9/6/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2021	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	001	6	8/20/2021	SUPPLEMENT FOR EXPANSION	$92,770
														Subtotal = $195,412

Issue Date FY: 2020 ( Subtotal = $102,642 )
2020	2020	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	000	5	4/14/2020	NON-COMPETING CONTINUATION	$102,642
														Subtotal = $102,642

Issue Date FY: 2019 ( Subtotal = $102,642 )
2019	2019	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	001	4	3/20/2019	NON-COMPETING CONTINUATION	$102,642
2019	2018	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	000	2	3/18/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $102,642

Issue Date FY: 2018 ( Subtotal = $135,000 )
2018	2018	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	000	2	4/18/2018	NON-COMPETING CONTINUATION	$135,000
2018	2018	UNIVERSITY OF OREGON	1585 E 13TH AVE	EUGENE	OR	97403	LANE	USA	Aging Research	002	3	8/4/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$90,043
2018	2018	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	001	2	8/3/2018	NON-COMPETING CONTINUATION	-$90,043
														Subtotal = $135,000

Issue Date FY: 2017 ( Subtotal = $135,000 )
2017	2017	BUCK INSTITUTE FOR RESEARCH ON AGING	8001 REDWOOD BLVD	NOVATO	CA	94945	MARIN	USA	Aging Research	000	1	4/4/2017	NEW	$135,000
														Subtotal = $135,000

Grand Total All Awards = $1,956,807

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Caenorhabditis Testing Program Data Coordinating Center

Award Number: U24AG056052

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/05/2017

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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