Tuesday, September 16, 2025 9/16/2025

State-dependent Decision-making in Brainwide Neural Circuits

Award Number: U19NS123716
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2021
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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State-dependent Decision-making in Brainwide Neural Circuits - Summary/Abstract Animals constantly make decisions, such as how to evaluate a potential threat or where to look for food. Yet the same animal in the same environment can produce different decisions on different occasions, because its internal state interacts powerfully with external inputs to determine behavior. This proposal’s overarching goal is to understand how internal states influence decisions and to identify the underlying neural mechanisms. In a mouse decision-making task, these experiments will examine the effects of three types of internal state changes: those arising spontaneously with engagement and disengagement in a task, those resulting from changing expectations during the task, and those resulting from learning within and across days. To determine how internal states affect brain activity and behavior, the team will apply cutting-edge technical advances on a brainwide scale, including statistical tools to infer internal states from behavior; simultaneous recordings from large populations of neurons across many regions during behavior and during optogenetic perturbations; assays that map functionally and molecularly defined cell-type-specific, cross-region connectivity; and computational approaches to model how cross-region neural communication depends on internal states. These ambitious goals go beyond the capabilities of an individual laboratory and are ideally suited for an already- productive consortium. This team is part of the International Brain Laboratory, which has already developed a standardized mouse decision-making task and standardized methods for training, neural measurement, and data analysis, along with a working, scalable infrastructure for sharing data. The proposed research leverages this existing infrastructure and takes it in a new direction. Projects 1-5 will examine simultaneously recorded population activity, evaluate causality, study neural activity and behavior during learning in normal and autism model mice, identify cell types by measuring neuronal activity, gene expression, and axonal projection patterns in the same populations of neurons, and build a comprehensive computational model of all these experimental results. Cores A-D will support the collection, replicability, management, and analysis of the large datasets produced by this brainwide examination of neural circuits. Taken together, the proposed research will rigorously define the neural basis of multiple internal states and evaluate their impact on the flow of decision-relevant information through the brain. The results will greatly advance the field by generating a comprehensive, mechanistic understanding of how internal states are reflected in the brain, and how these states interact with external inputs to guide decisions. Moreover, the team will produce and disseminate open-source tools and protocols that will enable other laboratories to collect and manage large-scale datasets produced through brainwide measurements.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $3,266,100 )
2025	2025	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	9/8/2025	NON-COMPETING CONTINUATION	$3,266,100
														Subtotal = $3,266,100

Issue Date FY: 2024 ( Subtotal = $3,313,112 )
2024	2024	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	7/19/2024	NON-COMPETING CONTINUATION	$3,280,464
2024	2024	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	615 W 131ST ST	NEW YORK	NY	10027	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	8/2/2024	SUPPLEMENT FOR EXPANSION	$32,648
														Subtotal = $3,313,112

Issue Date FY: 2023 ( Subtotal = $3,735,204 )
2023	2023	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	202 LOW LIBRARY 535 W 116 ST MC 4309,	NEW YORK	NY	10027	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	8/11/2023	NON-COMPETING CONTINUATION	$3,627,888
2023	2023	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	202 LOW LIBRARY 535 W 116 ST MC 4309,	NEW YORK	NY	10027	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	8/14/2023	SUPPLEMENT FOR EXPANSION	$107,316
														Subtotal = $3,735,204

Issue Date FY: 2022 ( Subtotal = $4,045,018 )
2022	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	202 LOW LIBRARY 535 W 116 ST MC 4309,	NEW YORK	NY	10027	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	2	8/1/2022	SUPPLEMENT FOR EXPANSION	$107,316
2022	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	116TH AND BDWY	NEW YORK	NY	10027	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	12/4/2021	SUPPLEMENT FOR EXPANSION	$74,668
2022	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	202 LOW LIBRARY 535 W 116 ST MC 4309,	NEW YORK	NY	10027	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	2	7/21/2022	NON-COMPETING CONTINUATION	$3,650,051
2022	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	202 LOW LIBRARY 535 W 116 ST MC 4309,	NEW YORK	NY	10027	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	004	2	8/19/2022	SUPPLEMENT FOR EXPANSION	$212,983
2022	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	202 LOW LIBRARY 535 W 116 ST MC 4309,	NEW YORK	NY	10027	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	1	5/13/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $4,045,018

Issue Date FY: 2021 ( Subtotal = $3,795,695 )
2021	2021	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	116TH AND BDWY	NEW YORK	NY	10027	NEW YORK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	8/4/2021	NEW	$3,795,695
														Subtotal = $3,795,695

Grand Total All Awards = $18,155,129

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State-dependent Decision-making in Brainwide Neural Circuits

Award Number: U19NS123716

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2021

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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