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Human immune memory to COVID-19, vaccines, and respiratory pathogens

Award Number: U19AI142742
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/11/2019
PERIOD OF PERFORMANCE END DATE: 02/28/2029

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Human immune memory to COVID-19, vaccines, and respiratory pathogens - OVERALL COMPONENT SUMMARY Our LJI CCHI was first funded in April of 2019 and has been highly impactful in human immunology research in the past < 4 years, particularly in the areas of COVID and COVID vaccines. Crotty and Sette published the first major paper on virus-specific T cell and antibody responses in COVID cases ( > 3,000 citations) and went on to collaboratively publish several more of the most influential T cell, B cell, and immune memory papers on COVID and COVID vaccines. The adaptive immune system is important for control of most viral infections. The three fundamental components of the adaptive immune system are B cells (the source of antibodies), CD4+ T cells, and CD8+ T cells. The armamentarium of B cells, CD4+ T cells, and CD8+ T cells has differing roles in different viral infections, and in vaccines, and thus it has been critical to directly study adaptive immunity to SARS2 (SARS2) to understand COVID. The COVID pandemic has been a historic disaster, with over 1 million American deaths and millions of deaths and billions of infections around the world, counterweighted by the exceptionally efficient development of COVID vaccines which had remarkable efficacy and have saved over 15 million lives in less than two years. In 2023 COVID remains a major American public health problem and global health problem, with COVID being the #3 cause of death in the USA in 2022, and in the USA there were over 1.6 million confirmed new cases of COVID in the month of January 2023 alone. Improvements in controlling COVID remain somewhat impaired by our limited understanding of immune memory and upper airways immunity to SARS2. The overarching focus connecting the three Projects in this LJI CCHI renewal proposal is immune memory, with emphasis on COVID, highlighted by three overall LJI CCHI themes: (1) understanding immune memory in humans from blood samples, rich in complexities; (2) understanding human upper airways T and B cell biology and memory; and (3) COVID immunobiology, including breakthrough infections, differences between COVID vaccines, and immunity relatedness to other respiratory viral infections of humans. These three themes are explored in depth in Projects 1-3 and the Clinical Core.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $5,153,530 )
2025	2025	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	003	7	7/17/2025	NON-COMPETING CONTINUATION	$2,576,765
2025	2025	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	002	4	1/22/2025	SUPPLEMENT FOR EXPANSION	$2,576,765
2025	2024	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	6	1/22/2025	COMPETING CONTINUATION	$5,217
2025	2023	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	5	1/22/2025	NON-COMPETING CONTINUATION	-$5,217
2025	2022	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	002	4	1/22/2025	SUPPLEMENT FOR EXPANSION	$0
2025	2022	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	6	1/22/2025	COMPETING CONTINUATION	$0
														Subtotal = $5,153,530

Issue Date FY: 2024 ( Subtotal = $2,595,434 )
2024	2024	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	6	3/15/2024	COMPETING CONTINUATION	$2,595,434
2024	2023	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	5	1/26/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,595,434

Issue Date FY: 2023 ( Subtotal = $2,713,421 )
2023	2023	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	5	3/14/2023	NON-COMPETING CONTINUATION	$2,713,421
2023	2022	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	4	2/16/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2022	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	002	4	8/25/2023	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,713,421

Issue Date FY: 2022 ( Subtotal = $4,330,604 )
2022	2022	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	4	4/22/2022	SUPPLEMENT FOR EXPANSION	$1,616,471
2022	2022	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	4	2/28/2022	NON-COMPETING CONTINUATION	$2,714,133
														Subtotal = $4,330,604

Issue Date FY: 2021 ( Subtotal = $9,083,840 )
2021	2021	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	002	3	3/17/2021	SUPPLEMENT FOR EXPANSION	$5,161,678
2021	2021	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	2	11/18/2020	SUPPLEMENT FOR EXPANSION	$1,263,917
2021	2021	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	3	3/15/2021	NON-COMPETING CONTINUATION	$2,658,245
														Subtotal = $9,083,840

Issue Date FY: 2020 ( Subtotal = $3,644,503 )
2020	2020	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	2	2/14/2020	NON-COMPETING CONTINUATION	$2,661,553
2020	2020	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	2	5/26/2020	SUPPLEMENT FOR EXPANSION	$982,950
														Subtotal = $3,644,503

Issue Date FY: 2019 ( Subtotal = $2,748,849 )
2019	2019	LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	1	3/8/2019	NEW	$2,748,849
														Subtotal = $2,748,849

Grand Total All Awards = $30,270,181

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Human immune memory to COVID-19, vaccines, and respiratory pathogens

Award Number: U19AI142742

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/11/2019

PERIOD OF PERFORMANCE END DATE: 02/28/2029

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