Saturday, July 5, 2025 7/5/2025

Center for Viral Systems Biology (CViSB)

Award Number: U19AI135995
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2018
PERIOD OF PERFORMANCE END DATE: 01/31/2028

Group Awards By:

View Award Description

Center for Viral Systems Biology (CViSB) - Project Summary - Center for Viral Systems Biology (CViSB) The COVID-19 pandemic is a stark reminder of the threat posed by infectious diseases, but other priority pathogens, such as Lassa and Ebola viruses, continue to pose signiﬁcant challenges in endemic areas. Infection with Lassa, Ebola, and SARS-CoV-2 viruses can lead to diverse acute and long-term outcomes, ranging from mild or asymptomatic disease to long-term sequelae or death. When we established the Center for Viral Systems Biology (CViSB, cvisb.org) in 2018, we set a main goal of answering why. With a focus on Ebola, Lassa, and via a scope expansion, COVID-19, we have achieved this goal by identifying clinical, immunological, genetic, and virus molecular factors that determine the outcome of disease. In this renewal application, we will move beyond standard systems biology data generation and analysis and use a reverse translational approach to expand on our prior work with a focus on both fundamental research and translational application. Our central hypothesis remains that complex networks of viral and human factors, including distinct clinical, immunological, genetic, virological, and physiological attributes play key roles in determining the outcome and spread of Lassa, Ebola, and COVID-19. Our overall goal is to identify these molecular networks and provide a deep system-level understanding of the virus, host, and environmental drivers of disease severity and spread to discover predictive markers of human disease. We will successfully achieve this goal by applying ‘omics’ technologies, wearables, and high-throughput experimental approaches to unique patient, vaccinee, and survivor cohorts in West Africa and the United States. Built around two interconnected projects and four cores, we will complete the following major goals: (1) we will integrate complex systems immunology, host genetic, physiological, clinical, and metabolic datasets to perform predictive modeling and deﬁne biosignatures that describe the risk, severity, and outcome of Lassa, Ebola, and COVID-19 using cohorts in West Africa and the United States. (2) We will integrate large-scale host-virus genomic datasets with population data and high-throughput experimental approaches to build multivariate network analyses and dynamic growth models to elucidate the molecular epidemiology, functional evolution, adaptive immunity, and host-pathogen dynamics of Lassa virus, Ebola virus, and SARS-CoV-2. (3) We will expand and develop high-throughput experimental methods, open-source software, machine learning tools, and web-based platforms to analyze and visualize large-scale datasets that enable real-time interrogation and interpretation of complex host-pathogen-environment network structures and dynamics. (4) We will continue to develop and maintain robust databases and application programming interfaces for open-source CViSB generated systems biology datasets and perform outreach and training to promote the use of systems biology to study infectious diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,568,706 )
2025	2025	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	8	2/18/2025	NON-COMPETING CONTINUATION	$2,568,706
														Subtotal = $2,568,706

Issue Date FY: 2024 ( Subtotal = $3,408,544 )
2024	2024	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	006	7	4/30/2024	NON-COMPETING CONTINUATION	$254,510
2024	2024	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	009	7	8/22/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2024	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	005	7	1/12/2024	NON-COMPETING CONTINUATION	$2,290,387
2024	2024	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	007	7	5/9/2024	SUPPLEMENT FOR EXPANSION	$43,647
2024	2024	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	010	7	9/4/2024	NON-COMPETING CONTINUATION	$0
2024	2024	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	008	7	8/20/2024	SUPPLEMENT FOR EXPANSION	$820,000
2024	2023	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	004	6	1/4/2024	COMPETING CONTINUATION	$0
2024	2023	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	6	10/18/2023	COMPETING CONTINUATION	$635,805
2024	2022	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	5	10/18/2023	NON-COMPETING CONTINUATION	-$635,805
2024	2021	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	003	4	10/18/2023	SUPPLEMENT FOR EXPANSION	$0
2024	2021	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	002	4	10/18/2023	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $3,408,544

Issue Date FY: 2023 ( Subtotal = $2,650,390 )
2023	2023	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	002	6	8/29/2023	COMPETING CONTINUATION	$0
2023	2023	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	6	2/6/2023	COMPETING CONTINUATION	$0
2023	2023	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	6	1/4/2023	COMPETING CONTINUATION	$2,650,390
														Subtotal = $2,650,390

Issue Date FY: 2022 ( Subtotal = $3,000,000 )
2022	2022	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	002	5	1/28/2022	NON-COMPETING CONTINUATION	$2,550,000
2022	2022	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	004	5	3/4/2022	NON-COMPETING CONTINUATION	$0
2022	2022	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	003	5	2/25/2022	SUPPLEMENT FOR EXPANSION	$450,000
2022	2021	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	005	4	3/4/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2021	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	4	10/19/2021	SUPPLEMENT FOR EXPANSION	$0
2022	2021	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	006	4	3/11/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2021	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	4	1/27/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $3,000,000

Issue Date FY: 2021 ( Subtotal = $4,360,690 )
2021	2021	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	005	4	7/28/2021	NON-COMPETING CONTINUATION	$0
2021	2021	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	006	4	9/2/2021	NON-COMPETING CONTINUATION	$168,625
2021	2021	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	3	12/11/2020	SUPPLEMENT FOR EXPANSION	$450,000
2021	2021	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	007	4	9/7/2021	SUPPLEMENT FOR EXPANSION	$597,119
2021	2021	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	004	4	3/24/2021	SUPPLEMENT FOR EXPANSION	$594,946
2021	2021	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	002	4	3/18/2021	NON-COMPETING CONTINUATION	$2,550,000
2021	2021	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	003	4	3/18/2021	SUPPLEMENT FOR EXPANSION	$450,000
2021	2020	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	3	12/11/2020	NON-COMPETING CONTINUATION	-$450,000
														Subtotal = $4,360,690

Issue Date FY: 2020 ( Subtotal = $3,872,765 )
2020	2020	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	3	5/15/2020	SUPPLEMENT FOR EXPANSION	$622,765
2020	2020	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	3	1/23/2020	NON-COMPETING CONTINUATION	$3,000,000
2020	2020	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	002	3	9/3/2020	SUPPLEMENT FOR EXPANSION	$250,000
														Subtotal = $3,872,765

Issue Date FY: 2019 ( Subtotal = $3,150,000 )
2019	2019	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	2	8/19/2019	NON-COMPETING CONTINUATION	$150,000
2019	2019	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	2	1/18/2019	NON-COMPETING CONTINUATION	$3,000,000
														Subtotal = $3,150,000

Issue Date FY: 2018 ( Subtotal = $3,000,000 )
2018	2018	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	1	1/29/2018	NEW	$3,000,000
														Subtotal = $3,000,000

Grand Total All Awards = $26,011,095

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Center for Viral Systems Biology (CViSB)

Award Number: U19AI135995

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2018

PERIOD OF PERFORMANCE END DATE: 01/31/2028

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer