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LJI Epitope Validation Center: Characterization of epitope-specific T cells responding to food, fungal and inner city allergens

Award Number: U19AI135731
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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CENTER PROGRAM SUMMARY/ABSTRACT Our proposal will use epitopes to comparatively evaluate immune responses in three different prototypic allergic diseases. We will study cockroach (CR) and mouse (MO) inhalation allergens, which are associated with the development of asthma in inner city children (Project 1); cow’s milk (CM), the most prevalently recognized pediatric food allergen (Project 2); and Aspergillus (ASP) and Alternaria (ALT) fungal allergens, which are associated with severe forms of asthma (Project 3). The extensive scientific overlap will offer opportunities for synergies between projects. Our study extensively utilizes cohorts independently funded by NIAID, to further multiply synergies and impact of the investigations. The evolution of responses will be examined as a function of time following natural exposure, exposure as part of work-duties and allergen immunotherapy (AIT). We will also study and compare individuals that are exposed but remain healthy, to people that have mild allergies and those that have severe asthma. Our hypothesis is that these distinct groups can be distinguished on the basis of their T cell response. Specifically, different groups might recognize different protein allergens or fragments (epitopes). It is also possible that the protein and genetic programs characteristic of T cells (T cell phenotypes) seen in allergic diseases of different types and severity will be unique. Our additional hypotheses are that evolution of T cell phenotypes can give us insights into the mechanism of allergic and asthmatic disease. If this were to be the case, it would have potential diagnostic value, and possibly suggest new therapeutic interventions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$54,969 )
2024	2022	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	5	11/16/2023	NON-COMPETING CONTINUATION	-$54,969
														Subtotal = -$54,969

Issue Date FY: 2022 ( Subtotal = $1,153,559 )
2022	2022	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	5	12/3/2021	NON-COMPETING CONTINUATION	$1,153,559
														Subtotal = $1,153,559

Issue Date FY: 2021 ( Subtotal = $1,279,239 )
2021	2021	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	4	8/11/2021	NON-COMPETING CONTINUATION	$199,933
2021	2021	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	4	12/23/2020	NON-COMPETING CONTINUATION	$1,079,306
														Subtotal = $1,279,239

Issue Date FY: 2020 ( Subtotal = $1,058,699 )
2020	2020	LA JOLLA INSTITUTE FOR IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	3	1/9/2020	NON-COMPETING CONTINUATION	$1,058,699
														Subtotal = $1,058,699

Issue Date FY: 2019 ( Subtotal = $1,040,067 )
2019	2019	LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	2	12/27/2018	NON-COMPETING CONTINUATION	$1,040,067
														Subtotal = $1,040,067

Issue Date FY: 2018 ( Subtotal = $1,100,687 )
2018	2018	LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY	9420 ATHENA CIR	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	1	12/26/2017	NEW	$1,100,687
														Subtotal = $1,100,687

Grand Total All Awards = $5,577,282

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LJI Epitope Validation Center: Characterization of epitope-specific T cells responding to food, fungal and inner city allergens

Award Number: U19AI135731

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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