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Malaria Epidemiology and Vector Biology of Anopheles stephensi across Rural and Urban Landscapes in Ethiopia

Award Number: U19AI129326
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/15/2017
PERIOD OF PERFORMANCE END DATE: 03/31/2029

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Malaria Epidemiology and Vector Biology of Anopheles stephensi across Rural and Urban Landscapes in Ethiopia - Malaria Epidemiology and Vector Biology of Invasive Anopheles stephensi Across Rural and Urban Landscapes in Ethiopia PROGRAM SUMMARY Anopheles stephensi is a major malaria vector species in South Asia. Since its first detection on the African continent in Djibouti in 2012, the distribution of this vector species has expanded to Ethiopia, Sudan, Somalia, Kenya, and Nigeria. The emergence and spread of An. stephensi in Africa pose serious challenges for malaria control and elimination in fast-growing urban Africa. Knowledge gaps related to An. stephensi ecology and behavior and the effectiveness of intervention methods in Africa have impeded the development of effective malaria control programs. Lack of sensitive surveillance methods for An. stephensi has also hindered efforts to effectively track An. stephensi population spread over time. To date, only limited basic research has examined the biology of invasive An. stephensi mosquitoes and the impact of An. stephensi invasion on malaria epidemiology in Africa. Little translational research has been conducted to develop new surveillance and control tools for An. stephensi. To address the major knowledge gaps and challenges in malaria control and elimination in the face of An. stephensi invasion and rapid spread across sub-Saharan Africa, our ICEMR established a consortium of outstanding institutions and investigators from the U.S. and Ethiopia to study critical scientific questions regarding malaria control and elimination efforts in the Greater Horn of Africa. The overarching goals of this ICEMR are to 1) address the knowledge gaps in invasive An. stephensi vector biology and malaria epidemiology across the rural to urban continuum in Ethiopia; 2) develop surveillance tools and methods needed to track vector spread; and 3) identify cost-effective vector control methods that can be adapted to settings of varying malaria endemicity. The ICEMR has two projects, each with multiple specific objectives. Project 1 will assess the vector biology of An. stephensi, elucidate the extent of spread of invasive An. stephensi, and develop serological biomarkers for An. stephensi exposure surveillance. Project 2 will examine the impact of An. stephensi invasion on malaria risk and determine the epidemiological impact and cost-effectiveness of larviciding methods targeting areas of high malaria risk across the rural to urban landscape. The administrative and data management cores will provide support to the entire program. Knowledge gained through this ICEMR is important to malaria control and elimination, not only in Ethiopia, but also in other African countries with invasive An. stephensi.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $905,004 )
2025	2025	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Allergy and Infectious Diseases Research	002	9	8/25/2025	NON-COMPETING CONTINUATION	$689,004
2025	2025	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Allergy and Infectious Diseases Research	003	9	8/26/2025	SUPPLEMENT FOR EXPANSION	$108,000
2025	2025	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Allergy and Infectious Diseases Research	004	9	8/26/2025	SUPPLEMENT FOR EXPANSION	$108,000
2025	2024	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Allergy and Infectious Diseases Research	001	8	2/14/2025	COMPETING CONTINUATION	$88,222
2025	2023	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Allergy and Infectious Diseases Research	000	7	2/14/2025	NON-COMPETING CONTINUATION	-$88,222
														Subtotal = $905,004

Issue Date FY: 2024 ( Subtotal = $1,132,408 )
2024	2024	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Allergy and Infectious Diseases Research	001	8	8/8/2024	COMPETING CONTINUATION	$59,175
2024	2024	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Allergy and Infectious Diseases Research	000	8	4/25/2024	COMPETING CONTINUATION	$873,233
2024	2024	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Allergy and Infectious Diseases Research	002	8	8/9/2024	SUPPLEMENT FOR EXPANSION	$200,000
														Subtotal = $1,132,408

Issue Date FY: 2023 ( Subtotal = $3,097,164 )
2023	2023	UNIVERSITY OF CALIFORNIA, IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Allergy and Infectious Diseases Research	000	7	3/30/2023	NON-COMPETING CONTINUATION	$3,097,164
														Subtotal = $3,097,164

Issue Date FY: 2022 ( Subtotal = $3,097,164 )
2022	2022	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Allergy and Infectious Diseases Research	000	6	4/11/2022	NON-COMPETING CONTINUATION	$2,447,164
2022	2022	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Allergy and Infectious Diseases Research	001	6	7/1/2022	NON-COMPETING CONTINUATION	$650,000
														Subtotal = $3,097,164

Issue Date FY: 2021 ( Subtotal = $2,447,164 )
2021	2021	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Allergy and Infectious Diseases Research	001	5	4/27/2021	SUPPLEMENT FOR EXPANSION	$1,078,950
2021	2021	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Allergy and Infectious Diseases Research	000	5	4/2/2021	NON-COMPETING CONTINUATION	$1,368,214
														Subtotal = $2,447,164

Issue Date FY: 2020 ( Subtotal = $2,090,612 )
2020	2020	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Allergy and Infectious Diseases Research	000	4	4/2/2020	NON-COMPETING CONTINUATION	$2,090,612
														Subtotal = $2,090,612

Issue Date FY: 2019 ( Subtotal = $2,315,304 )
2019	2019	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Allergy and Infectious Diseases Research	003	3	4/12/2019	SUPPLEMENT FOR EXPANSION	$722,400
2019	2019	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Allergy and Infectious Diseases Research	001	3	3/20/2019	NON-COMPETING CONTINUATION	$1,368,214
2019	2019	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Allergy and Infectious Diseases Research	002	3	4/11/2019	NON-COMPETING CONTINUATION	$224,690
2019	2018	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Allergy and Infectious Diseases Research	000	2	11/30/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,315,304

Issue Date FY: 2018 ( Subtotal = $1,578,968 )
2018	2018	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Allergy and Infectious Diseases Research	001	2	8/6/2018	NON-COMPETING CONTINUATION	$216,351
2018	2018	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Allergy and Infectious Diseases Research	000	2	3/28/2018	NON-COMPETING CONTINUATION	$1,362,617
														Subtotal = $1,578,968

Issue Date FY: 2017 ( Subtotal = $1,423,330 )
2017	2017	UNIVERSITY OF CALIFORNIA, IRVINE	141 INNOVATION DR STE 250	IRVINE	CA	92617	ORANGE	USA	Allergy and Infectious Diseases Research	000	1	4/15/2017	NEW	$1,423,330
														Subtotal = $1,423,330

Grand Total All Awards = $18,087,118

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Malaria Epidemiology and Vector Biology of Anopheles stephensi across Rural and Urban Landscapes in Ethiopia

Award Number: U19AI129326

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/15/2017

PERIOD OF PERFORMANCE END DATE: 03/31/2029

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