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A Genomics Based Investigation of the Determinants of Polymicrobial Infectious Disease Outcomes

Award Number: U19AI110820
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/15/2014
PERIOD OF PERFORMANCE END DATE: 03/31/2025

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A Genomics Based Investigation of the Determinants of Polymicrobial Infectious Disease Outcomes - The advent of high-throughput genomics and associated technologies have afforded the ability to begin to ask detailed questions about the biology of whole systems and the interactions of those parts, rather than examining parts of the system in isolation. This application contains studies that explore the dynamic interactions between pathogens, hosts, their microbiota and the immune system with the goal to provide a more comprehensive understanding of the determinants of infectious disease outcomes. Pathogens subvert host cells by using their gene products to manipulate cellular pathways for survival and replication; in turn, host cells respond to the invading pathogen through changes in gene expression. Deciphering these complex temporal and spatial dynamics to identify novel virulence factors or host response pathways is essential for complete understanding of the infectious disease process. However, even these approaches don't fully take into account the complexity of the interactions, given that the normal microbiota are also key players in these interactions. The majority of the members of the normal microbiota exist as mutualists that live in association with the host without causing disease. Yet, the interactions of a host, its microbiota, and a pathogen in the context of the host immune response, co-infections, anti-microbial therapies, or vaccines can greatly affect disease outcome. The integration of the high-throughput technology with the biological question highlights the evolution of genomics as an area of research from a strictly observational tool of only a few years ago, to being an integral part in the examination of the disease process and human health as a whole. The genomic viewpoint is becoming more complete, as we can begin to simultaneously characterize the interactions of host, pathogen and microbiota. The current application takes a systematic approach to the examination of not just a single pathogen, or the ecosystem that the pathogen is part of, but examines the impact of the other microbes and host factors on the infectious disease process. The integration of the data from these complex interactions is providing the foundation for a deeper understanding of health and disease. This proposal includes a highly collaborative group of investigators centered within the Institute for Genome Sciences at the University of Maryland and New York University who are experts in their respective areas of pathogen biology, but also are pioneers in the field of genomics. We expect that these studies will address major gaps in knowledge related to the molecular pathogenesis of viral, bacterial, fungal and parasitic pathogens.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	UNIVERSITY OF MARYLAND, BALTIMORE	220 ARCH ST OFC LEVEL2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	000	10	6/26/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	UNIVERSITY OF MARYLAND, BALTIMORE	220 ARCH ST OFC LEVEL2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	000	10	4/4/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $3,375,081 )
2023	2023	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	000	10	3/13/2023	NON-COMPETING CONTINUATION	$3,375,081
														Subtotal = $3,375,081

Issue Date FY: 2022 ( Subtotal = $3,428,670 )
2022	2022	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	001	9	8/19/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	000	9	3/25/2022	NON-COMPETING CONTINUATION	$3,428,670
														Subtotal = $3,428,670

Issue Date FY: 2021 ( Subtotal = $3,548,646 )
2021	2021	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	001	8	3/19/2021	NON-COMPETING CONTINUATION	$3,548,646
2021	2020	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	000	7	12/7/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,548,646

Issue Date FY: 2020 ( Subtotal = $3,600,000 )
2020	2020	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	000	7	3/25/2020	NON-COMPETING CONTINUATION	$3,600,000
														Subtotal = $3,600,000

Issue Date FY: 2019 ( Subtotal = $3,600,000 )
2019	2019	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	000	6	3/27/2019	COMPETING CONTINUATION	$3,600,000
2019	2019	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	002	6	9/23/2019	COMPETING CONTINUATION	$116,632
2019	2018	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	001	5	9/23/2019	NON-COMPETING CONTINUATION	-$116,632
														Subtotal = $3,600,000

Issue Date FY: 2018 ( Subtotal = $3,692,615 )
2018	2018	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	001	5	7/27/2018	NON-COMPETING CONTINUATION	$661,323
2018	2018	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	000	5	2/27/2018	NON-COMPETING CONTINUATION	$3,031,292
														Subtotal = $3,692,615

Issue Date FY: 2017 ( Subtotal = $3,399,039 )
2017	2017	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	001	4	3/29/2017	NON-COMPETING CONTINUATION	$2,944,790
2017	2017	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	002	4	8/3/2017	NON-COMPETING CONTINUATION	$473,289
2017	2017	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	004	4	8/8/2017	NON-COMPETING CONTINUATION	$0
2017	2017	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	003	4	8/4/2017	NON-COMPETING CONTINUATION	$1
2017	2016	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	000	3	3/24/2017	SUPPLEMENT FOR EXPANSION	-$19,041
														Subtotal = $3,399,039

Issue Date FY: 2016 ( Subtotal = $3,955,892 )
2016	2016	UNIVERSITY OF MARYLAND BALTIMORE PROFESSIONAL SCHOOLS	220 ARCH ST OFFICE LEVEL 2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	002	3	5/19/2016	NON-COMPETING CONTINUATION	$577,172
2016	2016	UNIVERSITY OF MARYLAND BALTIMORE PROFESSIONAL SCHOOLS	220 ARCH ST OFFICE LEVEL 2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	000	3	3/23/2016	NON-COMPETING CONTINUATION	$3,034,181
2016	2016	UNIVERSITY OF MARYLAND BALTIMORE PROFESSIONAL SCHOOLS	220 ARCH ST OFFICE LEVEL 2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	001	3	3/24/2016	SUPPLEMENT FOR EXPANSION	$50,355
2016	2016	UNIVERSITY OF MARYLAND BALTIMORE PROFESSIONAL SCHOOLS	220 ARCH ST OFFICE LEVEL 2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	004	3	8/11/2016	NON-COMPETING CONTINUATION	$283,999
2016	2016	UNIVERSITY OF MARYLAND BALTIMORE PROFESSIONAL SCHOOLS	220 ARCH ST OFFICE LEVEL 2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	003	3	8/4/2016	NON-COMPETING CONTINUATION	$10,185
														Subtotal = $3,955,892

Issue Date FY: 2015 ( Subtotal = $3,998,367 )
2015	2015	UNIVERSITY OF MARYLAND BALTIMORE PROFESSIONAL SCHOOLS	220 ARCH ST OFFICE LEVEL 2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	001	2	8/13/2015	NON-COMPETING CONTINUATION	$801,419
2015	2015	UNIVERSITY OF MARYLAND BALTIMORE PROFESSIONAL SCHOOLS	220 ARCH ST OFFICE LEVEL 2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	000	2	3/20/2015	NON-COMPETING CONTINUATION	$3,196,948
2015	2015	UNIVERSITY OF MARYLAND BALTIMORE PROFESSIONAL SCHOOLS	220 ARCH ST OFFICE LEVEL 2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	002	2	8/25/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,998,367

Issue Date FY: 2014 ( Subtotal = $3,926,048 )
2014	2014	UNIVERSITY OF MARYLAND BALTIMORE PROFESSIONAL SCHOOLS	220 ARCH ST OFFICE LEVEL 2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	001	1	8/14/2014	NEW	$774,796
2014	2014	UNIVERSITY OF MARYLAND BALTIMORE PROFESSIONAL SCHOOLS	220 ARCH ST OFFICE LEVEL 2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	002	1	9/17/2014	NEW	$0
2014	2014	UNIVERSITY OF MARYLAND BALTIMORE PROFESSIONAL SCHOOLS	220 ARCH ST OFFICE LEVEL 2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	000	1	4/15/2014	NEW	$3,151,252
														Subtotal = $3,926,048

Grand Total All Awards = $36,524,358

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A Genomics Based Investigation of the Determinants of Polymicrobial Infectious Disease Outcomes

Award Number: U19AI110820

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/15/2014

PERIOD OF PERFORMANCE END DATE: 03/31/2025

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