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Advancing genomic, transcriptomic and functional approaches to combat globally important and emerging pathogens

Award Number: U19AI110818
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/10/2014
PERIOD OF PERFORMANCE END DATE: 04/30/2027

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Advancing genomic, transcriptomic and functional approaches to combat globally important and emerging pathogens - Infectious diseases remain an important global threat despite the continuing invention of drugs, vaccines, and other effective interventions. Two principal factors drive this continued threat: 1) efficacious interventions are nearly always met with rapid evolutionary responses on the part of pathogens and disease-transmitting vectors, reducing their potency over time, and 2) the threat of infectious diseases is dynamic and exacerbated by the growing and increasingly connected human population, as evidenced by disruptive outbreaks, epidemics and pandemics in recent years driven by Zika, Ebola, Candida auris, antimicrobial-resistant bacteria and, of course, SARS-CoV-2. Genomics, transcriptomics, and associated scientific tools for investigating pathogens in precise detail and at tremendous scale offer new means to combat existing and emerging infectious diseases. Our GCID combines deeply experienced Management, Administrative, and Technology and Data teams, with scientists who have exceptional records in microbial genomics, to apply innovative approaches to crucial problems in infectious disease research. Our four Research Projects, devoted to viral, bacterial, fungal, and parasitic diseases, and vectors responsible for their transmission, will target high priority pathogens and pathogen-host-vector systems with a major impact on the global burden of disease. To maximize synergy between Projects, our research aims were developed with a common conceptual framework and shared approaches, and leverage working relationships that have been developed through years of close collaboration and scientific dialogue within our center and with the wider community of infectious disease research and public health officials. Using those shared concepts and approaches, supported by our Cores, our GCID will pursue three broad, long-range objectives across our four Projects: Specific Aim 1: Identify and profile novel threats and therapeutic targets. We hypothesize that selectively applying genomic methods to gather and prioritize information will accelerate counter measures against the emergence of resistance to existing therapeutics and effective responses to new disease emergencies and spillover events. Specific Aim 2: Inform clinical treatments for the benefit of patients and populations. We hypothesize that genomic and transcriptomic data will improve disease treatment by more rapidly and precisely defining the basis of resistance and virulence. Specific Aim 3: Drive precision public health surveillance and responses to disease emergence. We hypothesize that genomic analyses will improve our responses to infectious threats to support public health. Impact: We will develop innovative genomic approaches and datasets to address critical gaps in knowledge and capacity across diverse infectious diseases, and disseminate data and tools to the wider community.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$23,227 )
2025	2024	THE BROAD INSTITUTE, INC	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	002	11	11/21/2024	COMPETING CONTINUATION	$0
2025	2023	THE BROAD INSTITUTE, INC	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	000	10	10/21/2024	NON-COMPETING CONTINUATION	$0
2025	2021	THE BROAD INSTITUTE, INC	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	001	8	10/24/2024	SUPPLEMENT FOR EXPANSION	-$23,227
														Subtotal = -$23,227

Issue Date FY: 2024 ( Subtotal = $12,121,843 )
2024	2024	THE BROAD INSTITUTE, INC	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	002	11	7/25/2024	COMPETING CONTINUATION	$415,427
2024	2024	THE BROAD INSTITUTE, INC	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	001	11	5/14/2024	COMPETING CONTINUATION	$11,706,416
2024	2023	THE BROAD INSTITUTE, INC	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	000	10	5/10/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $12,121,843

Issue Date FY: 2023 ( Subtotal = $4,400,000 )
2023	2023	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	001	10	4/4/2023	NON-COMPETING CONTINUATION	$4,400,000
2023	2023	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	002	10	9/8/2023	NON-COMPETING CONTINUATION	$0
2023	2022	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	000	9	3/10/2023	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $4,400,000

Issue Date FY: 2022 ( Subtotal = $5,784,729 )
2022	2022	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	004	9	9/1/2022	SUPPLEMENT FOR EXPANSION	$1,384,729
2022	2022	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	000	9	4/15/2022	NON-COMPETING CONTINUATION	$4,400,000
2022	2022	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	001	9	8/22/2022	NON-COMPETING CONTINUATION	$0
2022	2021	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	003	8	8/23/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2021	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	002	8	8/23/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $5,784,729

Issue Date FY: 2021 ( Subtotal = $5,646,639 )
2021	2021	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	001	8	6/1/2021	NON-COMPETING CONTINUATION	$0
2021	2021	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	002	8	8/26/2021	SUPPLEMENT FOR EXPANSION	$450,000
2021	2021	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	003	8	8/27/2021	SUPPLEMENT FOR EXPANSION	$396,639
2021	2021	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	004	8	8/30/2021	SUPPLEMENT FOR EXPANSION	$400,000
2021	2021	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	000	8	4/1/2021	NON-COMPETING CONTINUATION	$4,400,000
														Subtotal = $5,646,639

Issue Date FY: 2020 ( Subtotal = $4,749,995 )
2020	2020	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	007	7	6/18/2020	SUPPLEMENT FOR EXPANSION	$349,995
2020	2020	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	006	7	5/12/2020	NON-COMPETING CONTINUATION	$4,400,000
2020	2019	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	002	6	12/23/2019	COMPETING CONTINUATION	$1,537,781
2020	2019	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	005	6	4/21/2020	COMPETING CONTINUATION	$21,097
2020	2019	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	003	6	1/1/2020	COMPETING CONTINUATION	$0
2020	2018	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	001	5	12/23/2019	NON-COMPETING CONTINUATION	-$1,537,781
2020	2018	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	000	5	12/5/2019	NON-COMPETING CONTINUATION	$0
2020	2018	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	004	5	4/21/2020	NON-COMPETING CONTINUATION	-$21,097
														Subtotal = $4,749,995

Issue Date FY: 2019 ( Subtotal = $4,400,000 )
2019	2019	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	000	6	4/22/2019	COMPETING CONTINUATION	$4,400,000
														Subtotal = $4,400,000

Issue Date FY: 2018 ( Subtotal = $5,496,338 )
2018	2018	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	003	5	8/29/2018	NON-COMPETING CONTINUATION	$1,016,363
2018	2018	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	000	5	3/21/2018	NON-COMPETING CONTINUATION	$4,479,975
2018	2018	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	001	5	8/16/2018	NON-COMPETING CONTINUATION	$0
2018	2018	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	002	5	8/20/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $5,496,338

Issue Date FY: 2017 ( Subtotal = $5,063,540 )
2017	2017	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	000	4	4/10/2017	NON-COMPETING CONTINUATION	$4,663,560
2017	2017	BROAD INSTITUTE, INC., THE	415 MAIN ST	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	001	4	8/18/2017	NON-COMPETING CONTINUATION	$399,980
														Subtotal = $5,063,540

Issue Date FY: 2016 ( Subtotal = $6,408,353 )
2016	2016	BROAD INSTITUTE INC	7 CAMBRIDGE CENTER	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	001	3	6/6/2016	NON-COMPETING CONTINUATION	$1,152,863
2016	2016	BROAD INSTITUTE INC	7 CAMBRIDGE CENTER	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	000	3	4/1/2016	NON-COMPETING CONTINUATION	$4,739,413
2016	2016	BROAD INSTITUTE INC	7 CAMBRIDGE CENTER	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	002	3	8/18/2016	NON-COMPETING CONTINUATION	$516,077
														Subtotal = $6,408,353

Issue Date FY: 2015 ( Subtotal = $6,971,854 ) (Continued on the next page)
2015	2015	BROAD INSTITUTE INC	7 CAMBRIDGE CENTER	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	004	2	9/7/2015	NON-COMPETING CONTINUATION	$0
2015	2015	BROAD INSTITUTE INC	7 CAMBRIDGE CENTER	CAMBRIDGE	MA	02142	MIDDLESEX	USA	Allergy and Infectious Diseases Research	003	2	9/2/2015	NON-COMPETING CONTINUATION	$1,877,229
Grand Total All Awards = $66,465,350

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Advancing genomic, transcriptomic and functional approaches to combat globally important and emerging pathogens

Award Number: U19AI110818

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/10/2014

PERIOD OF PERFORMANCE END DATE: 04/30/2027

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