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Systems Approach to Immunity and Inflammation

Award Number: U19AI100627
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2012
PERIOD OF PERFORMANCE END DATE: 08/31/2023

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Systems Approach to Immunity and Inflammation - Summary The innate immune response is a double-edged sword; it is absolutely required for host defense, but unregulated, causes inflammatory disease. Diverse and potent mechanisms have evolved to recognize and counter invading microorganisms. These include a variety of pattern recognition receptors, including Toll-like receptors (TLRs), RIG-I-like receptors (RLRs), Nod-like receptors (NLRs) and C-type lectin like receptors (CLRs) that recognize conserved molecular motifs on pathogens. While significant progress has been made in identifying the ligands detected by these receptors and the signaling cascades that they activate, a number of critical questions regarding the mechanisms that appropriately tailor the outputs of these pathways remain unanswered. Furthermore, the immune response to live pathogens is shaped by the interaction of multiple receptors and their cognate signaling pathways. The aggregate response is complex and cannot be predicted from analysis of each pathway in isolation; however, it is tractable using the tools of systems biology and forward genetics. Over the past 15 years members of this U19 consortium have collaborated using cross-disciplinary approaches to define the molecular mechanisms underlying the regulation of immune receptors and pathways. Their genetic approaches have also linked the pathways to pathogenesis and to immunity in vivo. These studies have also generated a significant body of work demonstrating cross-regulation between innate immune receptors. This U19 consists of two interrelated Projects that probe the innate immune response to infection. In Project 1, the Beutler laboratory will work in close collaboration with the Aderem, Nolan, and Ulevitch laboratories, taking a highly automated forward genetic approach to the analysis of innate immune signaling. In Project 2, the Aderem laboratory will determine mechanisms by which the TLR and type I interferon pathways cross-regulate each other. The Projects will be supported by three scientific Cores: The Signaling Core, will bring to bear several novel technologies for highly multiplexed molecular phenotyping of immune cells. The Data Management and Bioinformatics Core will support the individual Projects as well as the overall goals of the program through integrated computational analysis of all large-scale datasets. The Human Correlation Core will examine the relevance of mouse genes, demonstrated in Projects 1 and 2 to mediate innate immune functions, in the analogous human pathways.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$2,224 )
2024	2021	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	10	4/26/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2021	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	10	4/25/2024	NON-COMPETING CONTINUATION	-$2,224
														Subtotal = -$2,224

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	10	9/14/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $4,863,630 )
2021	2021	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	003	10	8/27/2021	SUPPLEMENT FOR EXPANSION	$471,985
2021	2021	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	002	10	8/27/2021	NON-COMPETING CONTINUATION	$2,201,411
2021	2021	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	9	11/24/2020	SUPPLEMENT FOR EXPANSION	$1,887,341
2021	2021	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	004	10	9/2/2021	SUPPLEMENT FOR EXPANSION	$302,893
2021	2020	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	9	2/8/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $4,863,630

Issue Date FY: 2020 ( Subtotal = $3,412,641 )
2020	2020	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	8	6/10/2020	SUPPLEMENT FOR EXPANSION	$366,597
2020	2020	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	9	8/17/2020	NON-COMPETING CONTINUATION	$2,207,462
2020	2020	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	002	9	8/20/2020	SUPPLEMENT FOR EXPANSION	$838,582
														Subtotal = $3,412,641

Issue Date FY: 2019 ( Subtotal = $2,213,320 )
2019	2019	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	8	8/20/2019	NON-COMPETING CONTINUATION	$2,213,320
														Subtotal = $2,213,320

Issue Date FY: 2018 ( Subtotal = $3,087,815 )
2018	2018	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	7	8/20/2018	NON-COMPETING CONTINUATION	$3,087,815
2018	2018	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	002	7	8/22/2018	NON-COMPETING CONTINUATION	$0
2018	2016	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	5	1/11/2018	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $3,087,815

Issue Date FY: 2017 ( Subtotal = $2,316,994 )
2017	2017	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	6	7/6/2017	COMPETING CONTINUATION	$2,316,994
2017	2015	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	4	2/16/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,316,994

Issue Date FY: 2016 ( Subtotal = $8,033,507 )
2016	2016	SCRIPPS RESEARCH INSTITUTE	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	5	8/24/2016	EXTENSION WITH OR WITHOUT FUNDS	$1,700,000
2016	2016	SCRIPPS RESEARCH INSTITUTE	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	5	8/3/2016	EXTENSION WITH OR WITHOUT FUNDS	$6,333,507
														Subtotal = $8,033,507

Issue Date FY: 2015 ( Subtotal = $6,324,437 )
2015	2015	SCRIPPS RESEARCH INSTITUTE	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	4	7/29/2015	NON-COMPETING CONTINUATION	$6,324,437
														Subtotal = $6,324,437

Issue Date FY: 2014 ( Subtotal = $6,339,499 )
2014	2014	SCRIPPS RESEARCH INSTITUTE	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	3	7/17/2014	NON-COMPETING CONTINUATION	$6,339,499
														Subtotal = $6,339,499

Issue Date FY: 2013 ( Subtotal = $6,166,888 )
2013	2013	SCRIPPS RESEARCH INSTITUTE	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	2	8/8/2013	NON-COMPETING CONTINUATION	$6,166,888
														Subtotal = $6,166,888

Issue Date FY: 2012 ( Subtotal = $6,357,746 )
2012	2012	SCRIPPS RESEARCH INSTITUTE	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	000	1	8/6/2012	NEW	$4,500,000
2012	2012	SCRIPPS RESEARCH INSTITUTE	10666 NORTH TORREY PINES ROAD	LA JOLLA	CA	92037	SAN DIEGO	USA	Allergy and Infectious Diseases Research	001	1	8/22/2012	NEW	$1,857,746
														Subtotal = $6,357,746

Grand Total All Awards = $49,114,253

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Systems Approach to Immunity and Inflammation

Award Number: U19AI100627

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2012

PERIOD OF PERFORMANCE END DATE: 08/31/2023

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