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Enhancing Performance of Antimicrobial Susceptibility Testing (AST) in Support of Vet-LIRN Activities

Award Number: U18FD008033
ORGANIZATION: FOOD AND DRUG ADMINISTRATION
OPDIV: FDA
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: KDA (KNOWLEDGE/DEVELOPMENT/APPLICATION)
PERIOD OF PERFORMANCE START DATE: 09/01/2023
PERIOD OF PERFORMANCE END DATE: 01/31/2026

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Enhancing Performance of Antimicrobial Susceptibility Testing (AST) in Support of Vet-LIRN Activities - Project Summary/Abstract: This comparison study is intended to compare Sensititre™ Vet AST COMPGP1F/COMPGN1F plates to bioMérieux Vitek® AST-GP81/AST-GN96 cards for performance of antimicrobial susceptibility testing (AST) results. This method comparison will be performed on common bacterial companion animal pathogens such as Escherichia coli, Enterococcus species, Staphylococcus pseundintermedius, Pseudomonas aeruginosa, and other Enterobacterales isolates. These bacterial pathogens may be shared between companion animals and humans; therefore, antimicrobial resistance (AMR) of these isolates is a critical concern. AST results on companion animals are significant for prediction of treatment outcome and are valuable comparisons to AMR trends occurring in humans. Although widely used in veterinary microbiology, AST plates manufactured by the currently dominating vendor, Sensititre™, are lacking the necessary range of antimicrobials to adequately detect common resistance mechanisms which would allow for appropriate comparison to AMR trends occurring in humans. The bioMérieux Vitek is commonly used in human microbiology laboratories; AST cards designed for this system incorporate ranges of antimicrobial concentrations of clinical and epidemiological interest for key indicators of antimicrobial resistance. Although the manufacturer has products designed for veterinary use, few laboratories in the United States use the bioMérieux Vitek instrument for AST. To date, there are no published studies comparing Sensititre™ AST to bioMérieux Vitek. Findings of this methods comparison will be published, which will provide objective data that veterinary diagnostic laboratories can use to determine which method is most appropriate for their laboratories. This comparison study will enhance AMR surveillance capabilities of the NDSU VDL and will directly support Vet-LIRN initiatives of protecting public health. This study may identify a reliable and affordable second vendor for AST in veterinary microbiology, which also ensures that all vendors continue offering useful veterinary products and encourages routine improvements of products offered to veterinary diagnostic laboratories.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	NORTH DAKOTA STATE UNIVERSITY	1340 ADMINISTRATION AVE	FARGO	ND	58105	CASS	USA	Food and Drug Administration Research	000	1	9/17/2025	NEW	$0
2025	2023	NORTH DAKOTA STATE UNIVERSITY	1340 ADMINISTRATION AVE	FARGO	ND	58105	CASS	USA	Food and Drug Administration Research	001	1	9/23/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	NORTH DAKOTA STATE UNIVERSITY	1301 12TH AVE N	FARGO	ND	58102	CASS	USA	Food and Drug Administration Research	000	1	7/18/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $84,637 )
2023	2023	NORTH DAKOTA STATE UNIVERSITY	1310 BOLLEY DR	FARGO	ND	58105	CASS	USA	Food and Drug Administration Research	000	1	8/16/2023	NEW	$84,637
														Subtotal = $84,637

Grand Total All Awards = $84,637

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Enhancing Performance of Antimicrobial Susceptibility Testing (AST) in Support of Vet-LIRN Activities

Award Number: U18FD008033

ORGANIZATION: FOOD AND DRUG ADMINISTRATION

OPDIV: FDA

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: KDA (KNOWLEDGE/DEVELOPMENT/APPLICATION)

PERIOD OF PERFORMANCE START DATE: 09/01/2023

PERIOD OF PERFORMANCE END DATE: 01/31/2026

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