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Continuation of NET-PD Trials at the University of Kansas Medical Center

Award Number: U10NS044469
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2002
PERIOD OF PERFORMANCE END DATE: 11/30/2014

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Continuation of NET-PD Trials at the University of Kansas Medical Center - DESCRIPTION (provided by applicant): Parkinson's disease (PD) affects an estimated one million persons in the United States and results in significant disability as the disease progresses, in many cases making daily activities difficult to complete. This disability leads to deterioration in the quality of life of both persons with PD and their caregivers. It also significantly increases healthcare costs and usage including hospitalizations and nursing home placement. One of the largest unmet needs in PD research is the identification of treatments that could be neuroprotective or slow the progression of the disease. The NET-PD program was established to address this issue by forming a network of clinical centers throughout North America with designated coordinating and statistical centers to identify and examine potential neuroprotective therapies. As part of this initiative 2 futility trials examining creatine, minocycline, co-enzyme Q10 and GPI-1485 were conducted as a unique approach for PD studies, to quickly identify potentially neuroprotective therapies. These studies suggested that creatine may have potential as a neuroprotective therapy for PD while the other therapies were found to be futile. This led to a large simple study of creatine (LS-1) which is a Phase III, randomized, double-blind, placebo-controlled, multi-center trial. The University of Kansas Medical Center enrolled subjects in both futility trials and is currently participating in the LS-1 study (31 subjects enrolled) as well as an additional trial, FS-ZONE, to examine the potential neuroprotective properties of pioglitazone. The specific aims of the current proposal are to complete ail follow-up evaluations such that the last subject enrolled in LS-1 has at least 5 years of follow-up. The study will allow for the examination of the long-term safety and efficacy of creatine as well as an examination of multiple data points to determine if there is a slowing of disease progression. The focus of the University of Kansas will be to complete all required study visits and assessments and to make sure that all remaining subjects (28) continue their participation in the study until its completion.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2014 ( Subtotal = $0 )
2014	2014	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	13	2/3/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2013 ( Subtotal = $59,018 )
2013	2013	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	12	12/27/2012	COMPETING CONTINUATION	$59,018
														Subtotal = $59,018

Issue Date FY: 2012 ( Subtotal = $58,241 )
2012	2012	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	11	1/12/2012	NON-COMPETING CONTINUATION	$58,241
														Subtotal = $58,241

Issue Date FY: 2011 ( Subtotal = $51,465 )
2011	2011	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	10	12/9/2010	NON-COMPETING CONTINUATION	$51,465
2011	2010	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	9	4/30/2011	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $51,465

Issue Date FY: 2010 ( Subtotal = $117,189 )
2010	2010	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	9	8/9/2010	SUPPLEMENT FOR EXPANSION	$42,600
2010	2010	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	3/6/2010	NON-COMPETING CONTINUATION	$60,693
2010	2010	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	9	9/24/2010	NON-COMPETING CONTINUATION	$13,896
														Subtotal = $117,189

Issue Date FY: 2009 ( Subtotal = $90,246 )
2009	2009	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	8	1/16/2009	NON-COMPETING CONTINUATION	$90,246
														Subtotal = $90,246

Issue Date FY: 2008 ( Subtotal = $77,429 )
2008	2008	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	7	1/23/2008	EXTENSION WITH OR WITHOUT FUNDS	$77,429
														Subtotal = $77,429

Issue Date FY: 2007 ( Subtotal = $52,838 )
2007	2007	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	6	3/1/2007	NON-COMPETING CONTINUATION	$52,838
														Subtotal = $52,838

Issue Date FY: 2006 ( Subtotal = $29,400 )
2006	2006	UNIVERSITY OF KANSAS, MEDICAL CENTER	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	12/9/2005	NON-COMPETING CONTINUATION	$0
2006	2006	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	5	2/10/2006	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$29,400
														Subtotal = $29,400

Issue Date FY: 2003 ( Subtotal = $108,045 )
2003	2003	UNIVERSITY OF KANSAS, MEDICAL CENTER	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	8/29/2003	NON-COMPETING CONTINUATION	$108,045
														Subtotal = $108,045

Issue Date FY: 2002 ( Subtotal = $108,658 )
2002	2002	UNIVERSITY OF KANSAS, MEDICAL CENTER	3901 RAINBOW BOULEVARD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/17/2002	NEW	$108,658
														Subtotal = $108,658

Grand Total All Awards = $752,529

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Continuation of NET-PD Trials at the University of Kansas Medical Center

Award Number: U10NS044469

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2002

PERIOD OF PERFORMANCE END DATE: 11/30/2014

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