Tuesday, July 1, 2025 7/1/2025

Blood and Marrow Transplant Clinical Trials Network

Award Number: U10HL069254
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2001
PERIOD OF PERFORMANCE END DATE: 06/30/2017

Group Awards By:

View Award Description

Blood and Marrow Transplant Clinical Trials Network - DESCRIPTION (provided by applicant): Over the past two decades, advances in the practice of allogeneic hematopoietic cell transplantation (HCT) have resulted in decreased transplant related mortality (TRM), expanded access to older and/or medically at- risk populations, and the development of alternative approaches for patients without appropriately HLA- matched donors (unrelated cord blood [UCB] and haploidentical grafts), in addition, tantalizing hints of potentially beneficial novel cellular therapy approaches are appearing in single or limited center studies. Significant problems remain, however. Relapse is the largest cause for failure, and prevention of relapse and/or salvage therapies for relapse must be key goals of the BMT CTN moving forward. Graft-vs-host disease (GVHD) continues to cause unacceptable morbidity, especially In the expanding number of older patients receiving reduced intensity PBSC approaches. Alternative donor approaches are plagued with high rates of rejection and TRM. Finally, the success of HCT for non-malignant disorders using unrelated donor (URD) sources is limited by excessive GVHD, TRM, and rejection, and could benefit from disease-specific optimization of transplant approaches. The Pediatric Blood and Marrow Transplant Consortium (PBMTC), a group consisting 75 ofthe finest pediatric HCT centers in North America and Australia, Is uniquely qualified to address these important issues. The PBMTC has been one of the top Core Centers over the last two grant periods in patient accrual, data quality, laboratory compliance, and leadership. The PBMTC has collaborative agreements with the Children's Oncology Group (COG) and with the clinical trials arm of the Center for International Blood and Marrow Transplant Research (CIBMTR) that allow it to be a strong voice In the development of pediatric-focused trials and In providing developmental assistance and enrollment for combined pediatric/adult BMT CTN trials. The PBMTC proposal for this BMT CTN Core Center renewal grant seeks to optimize a highly immunoablative reduced Intensity preparative regimen for the treatment of hemophagocytic disorders. Preliminary data from PBMTC centers show promise of decreasing transplant related mortality from 35% to as little as 10% using the proposed regimen. The proposal contains significant biology questions focused upon decreasing GVHD, improving engraftment, defining optimal alemtuzumab dosing and dose timing, and correlating key genetic and immunologic measures with outcome. Success with this trial will change the standard of care for treatment of these diseases and lay the foundation for adaptation of similar approaches to other complex non-malignant conditions. RELEVANCE (See instructions): The Blood and Marrow Transplant Clinical Trials Network (BMT CTN) should study novel approaches to prevent relapse, reduce graft vs. host disease, develop better alternative donor methods, and improve outcomes for patients with non-malignant diseases. The Pediatric Blood and Marrow Transplant Consortium (PBMTC) brings significant pediatric expertise and a proven track record to the BMT CTN. The PBMTC Core Center proposal alms to improve survival using a novel approach to treat hemophagocytic disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = -$27,605 )
2018	2016	THE CHILDRENS HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Blood Diseases and Resources Research	000	16	1/5/2018	NON-COMPETING CONTINUATION	-$27,605
														Subtotal = -$27,605

Issue Date FY: 2016 ( Subtotal = $172,328 )
2016	2016	CHILDRENS HOSPITAL OF LOS ANGELES	4650 SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Blood Diseases and Resources Research	000	16	5/24/2016	NON-COMPETING CONTINUATION	$172,328
														Subtotal = $172,328

Issue Date FY: 2015 ( Subtotal = $172,328 )
2015	2015	CHILDRENS HOSPITAL OF LOS ANGELES	4650 SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Cardiovascular Diseases Research	000	15	8/14/2015	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$172,328
														Subtotal = $172,328

Issue Date FY: 2014 ( Subtotal = $117,888 )
2014	2014	UNIVERSITY OF UTAH	201 SOUTH PRESIDENT`S CIRCLE	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cardiovascular Diseases Research	000	14	5/24/2014	NON-COMPETING CONTINUATION	$117,888
														Subtotal = $117,888

Issue Date FY: 2013 ( Subtotal = $117,888 )
2013	2013	UNIVERSITY OF UTAH	201 SOUTH PRESIDENT`S CIRCLE	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cardiovascular Diseases Research	001	13	8/8/2013	NON-COMPETING CONTINUATION	$5,660
2013	2013	UNIVERSITY OF UTAH	201 SOUTH PRESIDENT`S CIRCLE	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cardiovascular Diseases Research	000	13	6/12/2013	NON-COMPETING CONTINUATION	$112,228
														Subtotal = $117,888

Issue Date FY: 2012 ( Subtotal = $130,410 )
2012	2012	UNIVERSITY OF UTAH	201 SOUTH PRESIDENT`S CIRCLE	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Cardiovascular Diseases Research	000	12	5/31/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$130,410
														Subtotal = $130,410

Issue Date FY: 2011 ( Subtotal = $128,158 )
2011	2011	NATIONAL CHILDHOOD CANCER FOUNDATION	POST OFFICE BOX 60012	ARCADIA	CA	91006	LOS ANGELES	USA	Cardiovascular Diseases Research	000	11	8/8/2011	COMPETING CONTINUATION	$128,158
														Subtotal = $128,158

Grand Total All Awards = $811,395

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Blood and Marrow Transplant Clinical Trials Network

Award Number: U10HL069254

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2001

PERIOD OF PERFORMANCE END DATE: 06/30/2017

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer