Wednesday, December 4, 2024 12/4/2024

Children's Oncology Group Chair's Grant

Award Number: U10CA098543
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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DESCRIPTION (Provided by applicant): During the past four decades, survival rates and cure for childhood cancer have improved dramatically. Previously a nearly uniformly fatal disease when not amenable to surgical management alone, cancer is now curable in the majority of children. This improvement is a direct result of the collaborative efforts of clinical and laboratory investigators in the context of cooperative, multi-center clinical trials. Further significant improvements in overall survival have been recently attained in some specific pediatric cancers. However, improvement has not been observed in all diagnostic types of childhood cancer. Recognizing the need to accelerate progress despite the difficulties encountered with limited patient numbers and constrained resources, the Children's Oncology Group (COG) successfully elected to unify its efforts to develop a coordinated and robust research agenda without sacrificing the progress that had resulted from previous competitive strategies in specific disease areas. Major refinements in risk classification based on expanded understanding of disease and host biology in larger numbers of patients have resulted from these efforts. Refinements in the definition of risk groups and increasing subgroups of patients and rare cancer types necessitate even more cooperation. Therapeutic intensification from augmentation of conventional agents and schedule modification is unlikely to result in further improvement, providing a compelling justification and emergent need to enhance correlative biologic investigation and accelerate the process of identification and validation of molecular targets in specific pediatric cancers. Moreover, incremental progress requires that pediatric cancer clinical investigation fully exploit evolving developments in molecular cancer therapeutics in a more rapid drug development paradigm than heretofore utilized for childhood cancer, especially for those types resistant to conventional therapies; this is also required to reduce the potential for significant acute and long-term sequelae associated with current therapy. In order to achieve its mission to cure and prevent childhood cancer, the COG will design and conduct clinical trials that will continue to define evidence-based care standards, conduct laboratory investigations into cancer biology and variability in host response to treatment and translate these findings into new, more effective and less toxic treatments. We will identify causes of childhood cancer and develop strategies aimed at cancer prevention. Finally, we will evaluate therapeutic interventions with a goal of improving the quality of life and survivorship in infant, children, adolescents and young adults with cancer.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = -$103 )
2018	2013	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Treatment Research	000	11	2/8/2018	NON-COMPETING CONTINUATION	-$103
														Subtotal = -$103

Issue Date FY: 2017 ( Subtotal = -$103,763 )
2017	2013	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Treatment Research	000	11	2/14/2017	NON-COMPETING CONTINUATION	-$103,763
														Subtotal = -$103,763

Issue Date FY: 2015 ( Subtotal = $0 )
2015	2013	CHILDREN'S HOSPITAL OF PHILADELPHIA	34TH ST & CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Treatment Research	000	11	4/21/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2013 ( Subtotal = $24,937,728 )
2013	2013	CHILDREN'S HOSPITAL OF PHILADELPHIA	34TH ST & CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Treatment Research	006	11	7/18/2013	NON-COMPETING CONTINUATION	$8,044,299
2013	2013	CHILDREN'S HOSPITAL OF PHILADELPHIA	34TH ST & CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Treatment Research	005	11	3/29/2013	NON-COMPETING CONTINUATION	$14,962,483
2013	2013	CHILDREN'S HOSPITAL OF PHILADELPHIA	34TH ST & CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Treatment Research	007	11	9/5/2013	NON-COMPETING CONTINUATION	$1,888,169
2013	2013	CHILDREN'S HOSPITAL OF PHILADELPHIA	34TH ST & CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Treatment Research	004	10	1/25/2013	SUPPLEMENT FOR EXPANSION	$42,777
2013	2010	CHILDREN'S HOSPITAL OF PHILADELPHIA	34TH ST & CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Trans-NIH Recovery Act Research Support	001	10	10/18/2012	SUPPLEMENT FOR EXPANSION	$103,000
2013	2010	NATIONAL CHILDHOOD CANCER FOUNDATION	POST OFFICE BOX 60012	ARCADIA	CA	91006	LOS ANGELES	USA	Trans-NIH Recovery Act Research Support	000	8	10/18/2012	SUPPLEMENT FOR EXPANSION	-$103,000
2013	2009	CHILDREN'S HOSPITAL OF PHILADELPHIA	34TH ST & CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Trans-NIH Recovery Act Research Support	003	10	11/2/2012	SUPPLEMENT FOR EXPANSION	$189,370
2013	2009	NATIONAL CHILDHOOD CANCER FOUNDATION	POST OFFICE BOX 60012	ARCADIA	CA	91006	LOS ANGELES	USA	Trans-NIH Recovery Act Research Support	002	7	11/2/2012	SUPPLEMENT FOR EXPANSION	-$189,370
														Subtotal = $24,937,728

Issue Date FY: 2012 ( Subtotal = $27,316,911 )
2012	2012	CHILDREN'S HOSPITAL OF PHILADELPHIA	34TH ST & CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Treatment Research	000	10	4/13/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$18,166,939
2012	2012	CHILDREN'S HOSPITAL OF PHILADELPHIA	34TH ST & CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Treatment Research	010	10	9/26/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,460,992
2012	2012	CHILDREN'S HOSPITAL OF PHILADELPHIA	34TH ST & CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Treatment Research	008	10	9/7/2012	SUPPLEMENT FOR EXPANSION	$176,626
2012	2012	CHILDREN'S HOSPITAL OF PHILADELPHIA	34TH ST & CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Treatment Research	003	10	7/11/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$406,556
2012	2012	CHILDREN'S HOSPITAL OF PHILADELPHIA	34TH ST & CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Treatment Research	004	10	8/2/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$7,105,798
2012	2009	CHILDREN'S HOSPITAL OF PHILADELPHIA	34TH ST & CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Trans-NIH Recovery Act Research Support	005	10	8/17/2012	SUPPLEMENT FOR EXPANSION	$0
2012	2009	CHILDREN'S HOSPITAL OF PHILADELPHIA	34TH ST & CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Trans-NIH Recovery Act Research Support	009	10	9/13/2012	SUPPLEMENT FOR EXPANSION	$0
2012	2009	NATIONAL CHILDHOOD CANCER FOUNDATION	POST OFFICE BOX 60012	ARCADIA	CA	91006	LOS ANGELES	USA	Trans-NIH Recovery Act Research Support	001	7	6/29/2012	SUPPLEMENT FOR EXPANSION	-$22,800
2012	2009	NATIONAL CHILDHOOD CANCER FOUNDATION	POST OFFICE BOX 60012	ARCADIA	CA	91006	LOS ANGELES	USA	Trans-NIH Recovery Act Research Support	006	7	9/5/2012	SUPPLEMENT FOR EXPANSION	-$144,261
2012	2009	CHILDREN'S HOSPITAL OF PHILADELPHIA	34TH ST & CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Trans-NIH Recovery Act Research Support	007	10	9/5/2012	SUPPLEMENT FOR EXPANSION	$144,261
2012	2009	CHILDREN'S HOSPITAL OF PHILADELPHIA	34TH ST & CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Trans-NIH Recovery Act Research Support	002	10	6/29/2012	SUPPLEMENT FOR EXPANSION	$22,800
														Subtotal = $27,316,911

Issue Date FY: 2011 ( Subtotal = $28,185,548 )
2011	2011	NATIONAL CHILDHOOD CANCER FOUNDATION	POST OFFICE BOX 60012	ARCADIA	CA	91006	LOS ANGELES	USA	Cancer Treatment Research	002	9	8/11/2011	NON-COMPETING CONTINUATION	$113,271
2011	2011	NATIONAL CHILDHOOD CANCER FOUNDATION	POST OFFICE BOX 60012	ARCADIA	CA	91006	LOS ANGELES	USA	Cancer Treatment Research	003	9	9/27/2011	SUPPLEMENT FOR EXPANSION	$1,375,035
2011	2011	NATIONAL CHILDHOOD CANCER FOUNDATION	POST OFFICE BOX 60012	ARCADIA	CA	91006	LOS ANGELES	USA	Cancer Treatment Research	001	9	6/14/2011	SUPPLEMENT FOR EXPANSION	$44,161
2011	2011	NATIONAL CHILDHOOD CANCER FOUNDATION	POST OFFICE BOX 60012	ARCADIA	CA	91006	LOS ANGELES	USA	Cancer Treatment Research	000	9	4/8/2011	NON-COMPETING CONTINUATION	$26,653,081
														Subtotal = $28,185,548

Issue Date FY: 2010 ( Subtotal = $31,269,560 )
2010	2010	NATIONAL CHILDHOOD CANCER FOUNDATION	POST OFFICE BOX 60012	ARCADIA	CA	91006	LOS ANGELES	USA	Cancer Treatment Research	010	8	6/29/2010	SUPPLEMENT FOR EXPANSION	$44,161
2010	2010	NATIONAL CHILDHOOD CANCER FOUNDATION	POST OFFICE BOX 60012	ARCADIA	CA	91006	LOS ANGELES	USA	Trans-NIH Recovery Act Research Support	012	8	9/22/2010	SUPPLEMENT FOR EXPANSION	$976,412
2010	2010	NATIONAL CHILDHOOD CANCER FOUNDATION	POST OFFICE BOX 60012	ARCADIA	CA	91006	LOS ANGELES	USA	Trans-NIH Recovery Act Research Support	008	8	6/15/2010	SUPPLEMENT FOR EXPANSION	$0
2010	2010	NATIONAL CHILDHOOD CANCER FOUNDATION	POST OFFICE BOX 60012	ARCADIA	CA	91006	LOS ANGELES	USA	Cancer Treatment Research	011	8	9/21/2010	SUPPLEMENT FOR EXPANSION	$216,000
2010	2010	NATIONAL CHILDHOOD CANCER FOUNDATION	POST OFFICE BOX 60012	ARCADIA	CA	91006	LOS ANGELES	USA	Trans-NIH Recovery Act Research Support	007	8	5/28/2010	SUPPLEMENT FOR EXPANSION	$498,467
2010	2010	NATIONAL CHILDHOOD CANCER FOUNDATION	POST OFFICE BOX 60012	ARCADIA	CA	91006	LOS ANGELES	USA	Cancer Treatment Research	009	8	6/23/2010	SUPPLEMENT FOR EXPANSION	$685,980
2010	2010	NATIONAL CHILDHOOD CANCER FOUNDATION	POST OFFICE BOX 60012	ARCADIA	CA	91006	LOS ANGELES	USA	Cancer Treatment Research	006	8	3/3/2010	NON-COMPETING CONTINUATION	$26,966,030
2010	2009	NATIONAL CHILDHOOD CANCER FOUNDATION	POST OFFICE BOX 60012	ARCADIA	CA	91006	LOS ANGELES	USA	Trans-NIH Recovery Act Research Support	004	7	12/14/2009	SUPPLEMENT FOR EXPANSION	$0
2010	2009	NATIONAL CHILDHOOD CANCER FOUNDATION	POST OFFICE BOX 60012	ARCADIA	CA	91006	LOS ANGELES	USA	Trans-NIH Recovery Act Research Support	002	7	12/14/2009	SUPPLEMENT FOR EXPANSION	$1,882,510
2010	2009	NATIONAL CHILDHOOD CANCER FOUNDATION	POST OFFICE BOX 60012	ARCADIA	CA	91006	LOS ANGELES	USA	Cancer Treatment Research	000	7	10/19/2009	NON-COMPETING CONTINUATION	$0
2010	2009	NATIONAL CHILDHOOD CANCER FOUNDATION	POST OFFICE BOX 60012	ARCADIA	CA	91006	LOS ANGELES	USA	Trans-NIH Recovery Act Research Support	001	7	12/7/2009	SUPPLEMENT FOR EXPANSION	$0
2010	2009	NATIONAL CHILDHOOD CANCER FOUNDATION	POST OFFICE BOX 60012	ARCADIA	CA	91006	LOS ANGELES	USA	Trans-NIH Recovery Act Research Support	003	7	12/14/2009	SUPPLEMENT FOR EXPANSION	$0
2010	2009	NATIONAL CHILDHOOD CANCER FOUNDATION	POST OFFICE BOX 60012	ARCADIA	CA	91006	LOS ANGELES	USA	Cancer Treatment Research	005	7	1/25/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $31,269,560

Issue Date FY: 2009 ( Subtotal = $35,539,001 ) (Continued on the next page)
2009	2009	NATIONAL CHILDHOOD CANCER FOUNDATION	POST OFFICE BOX 60012	ARCADIA	CA	91006	LOS ANGELES	USA	Cancer Treatment Research	005	7	9/28/2009	NON-COMPETING CONTINUATION	$1,192,598
2009	2009	NATIONAL CHILDHOOD CANCER FOUNDATION	POST OFFICE BOX 60012	ARCADIA	CA	91006	LOS ANGELES	USA	Trans-NIH Recovery Act Research Support	013	7	8/28/2009	SUPPLEMENT FOR EXPANSION	$255,908
2009	2009	NATIONAL CHILDHOOD CANCER FOUNDATION	POST OFFICE BOX 60012	ARCADIA	CA	91006	LOS ANGELES	USA	Cancer Treatment Research	012	7	8/24/2009	SUPPLEMENT FOR EXPANSION	$161,187
Grand Total All Awards = $305,214,911

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Children's Oncology Group Chair's Grant

Award Number: U10CA098543

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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