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1/2 - Regional GEOhealth Hub Centered In Peru-Peru

Award Number: U01TW010107
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/28/2015
PERIOD OF PERFORMANCE END DATE: 02/28/2027

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1/2 - Regional GEOhealth Hub Centered In Peru-Peru - In Latin America, about 172 million or 58% of the population, live in 366 cities comprising over 100,000 residents, all of which have ambient air pollution (AAP) levels above WHO recommended level of 10 μg/m3 annual average for PM2.5. Exposure to AAP, both short and long-term, is associated with higher morbidity and mortality from cardiovascular and respiratory diseases, and there is increasing evidence for Alzheimer’s disease and dementia as well. AAP in Lima, Peru’s largest city, averaged 25 μg/m3 in 2010-2016. The 2nd largest city, Arequipa, averaged 72 μg/m3 at a downtown monitor in 2018. Both cities are far above WHO guidelines of 10 μg/m3. As in many other LMICs, AAP monitoring in Peru is limited; most observations taken by the government are limited to Lima and to a few ground monitors. We propose to extend our prior (2010-2016) 1 k2 -resolution PM2,5 model for Lima through 2025, and also develop a new Lima model for NO2. With these data we will study the association of traffic and air pollution in Lima and evaluate possible different mitigation strategies in terms of reducing air pollution and related respiratory diseases. We will also study the association of AAP and COVID-19 (and all pneumonia) incidence, mortality, and case-fatality in Lima in the year before vaccination was introduced; Peru was hit hard by COVID-19, and has the highest COVID-19 mortality rate in the world. We will also assess whether severe COVID-19 is associated with cognitive deficits 2-4 years afterwards, comparing 100 cases with 100 controls. In addition, we will conduct the first study of Alzheimer disease (AD) and fronto-temporal dementia (FTD) and air pollution in Lima, taking an advantage of an ongoing cohort study with over 500 cases and 500 controls, conducted by a leading Alzheimer’s disease center; in this study we will also assess whether Alzheimer’s disease cases, or fronto-temporal dementia cases were more likely to have had COVID than controls. We also plan to develop a national model for PM2.5 for Peru as a whole, with 5 k2 resolution, and a corresponding data base of hospital data and emergency room visits for all the major cities of the country. With these data we will estimate premature mortality from cardiovascular and respiratory disease due to PM2.5 in Peru. We may also be able to extend our study of Alzheimer’s disease to other urban centers outside of Lima. We will furthermore study possible mitigation strategies for PM2.5 nationwide, which will reduce both PM2.5 and greenhouse gases (produced from many of the same sources), and study their impact on Peru’s obligations to reduce greenhouse gases under the Paris accord.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $299,990 )
2025	2025	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AVENIDA HONORIO DELGADO 430 URB URB INGENIERIA	LIMA				PER	International Research and Research Training	000	9	3/17/2025	NON-COMPETING CONTINUATION	$299,990
														Subtotal = $299,990

Issue Date FY: 2024 ( Subtotal = $299,996 )
2024	2024	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AVENIDA HONORIO DELGADO 430 URB URB INGENIERIA	LIMA				PER	International Research and Research Training	003	8	2/14/2024	NON-COMPETING CONTINUATION	$299,996
2024	2023	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AVENIDA HONORIO DELGADO 430 URB URB INGENIERIA	LIMA				PER	International Research and Research Training	004	7	2/14/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2023	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AVENIDA HONORIO DELGADO 430 URB URB INGENIERIA	LIMA				PER	International Research and Research Training	001	7	2/14/2024	NON-COMPETING CONTINUATION	$0
2024	2022	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AVENIDA HONORIO DELGADO 430 URB URB INGENIERIA	LIMA				PER	International Research and Research Training	002	6	2/14/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2022	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AVENIDA HONORIO DELGADO 430 URB URB INGENIERIA	LIMA				PER	International Research and Research Training	000	6	2/14/2024	COMPETING CONTINUATION	$0
														Subtotal = $299,996

Issue Date FY: 2023 ( Subtotal = $480,891 )
2023	2023	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AVENIDA HONORIO DELGADO 430 URB URB INGENIERIA	LIMA				PER	International Research and Research Training	003	7	9/26/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2023	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AVENIDA HONORIO DELGADO 430 URB URB INGENIERIA	LIMA				PER	International Research and Research Training	002	7	9/11/2023	SUPPLEMENT FOR EXPANSION	$180,901
2023	2023	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AVENIDA HONORIO DELGADO 430 URB URB INGENIERIA	LIMA				PER	International Research and Research Training	000	7	2/24/2023	NON-COMPETING CONTINUATION	$299,990
2023	2020	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AVENIDA HONORIO DELGADO 430 URB URB INGENIERIA	LIMA				PER	International Research and Research Training	001	5	6/20/2023	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $480,891

Issue Date FY: 2022 ( Subtotal = $417,554 )
2022	2022	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AV. HONORIO DELGADO 430	LIMA	LIMA			PER	International Research and Research Training	001	6	6/18/2022	COMPETING CONTINUATION	$0
2022	2022	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AV. HONORIO DELGADO 430	LIMA	LIMA			PER	International Research and Research Training	003	6	9/7/2022	SUPPLEMENT FOR EXPANSION	$113,886
2022	2022	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AV. HONORIO DELGADO 430	LIMA	LIMA			PER	International Research and Research Training	000	6	6/3/2022	COMPETING CONTINUATION	$299,995
2022	2022	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AV. HONORIO DELGADO 430	LIMA	LIMA			PER	International Research and Research Training	002	6	8/19/2022	SUPPLEMENT FOR EXPANSION	$3,673
														Subtotal = $417,554

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AV. HONORIO DELGADO 430	LIMA	LIMA			PER	International Research and Research Training	000	5	7/22/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2019	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AV. HONORIO DELGADO 430	LIMA	LIMA			PER	International Research and Research Training	001	5	7/29/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $200,000 )
2020	2020	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AV. HONORIO DELGADO 430	LIMA	LIMA	15102		PER	International Research and Research Training	002	5	8/1/2020	SUPPLEMENT FOR EXPANSION	$200,000
2020	2019	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AV. HONORIO DELGADO 430	LIMA	LIMA	15102		PER	International Research and Research Training	000	5	5/15/2020	NON-COMPETING CONTINUATION	$0
2020	2019	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AV. HONORIO DELGADO 430	LIMA	LIMA	15102		PER	International Research and Research Training	001	5	8/1/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $200,000

Issue Date FY: 2019 ( Subtotal = $299,980 )
2019	2019	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AV. HONORIO DELGADO 430 URB. INGENIERIA	LIMA		31		PER	International Research and Research Training	001	5	8/11/2019	NON-COMPETING CONTINUATION	$299,980
2019	2018	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AV. HONORIO DELGADO 430 URB. INGENIERIA	LIMA		31		PER	International Research and Research Training	000	4	4/30/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $299,980

Issue Date FY: 2018 ( Subtotal = $349,573 )
2018	2018	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AV. HONORIO DELGADO 430 URB. INGENIERIA	LIMA		31		PER	International Research and Research Training	001	4	8/17/2018	NON-COMPETING CONTINUATION	$0
2018	2018	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AV. HONORIO DELGADO 430 URB. INGENIERIA	LIMA		31		PER	International Research and Research Training	003	4	9/20/2018	NON-COMPETING CONTINUATION	$0
2018	2018	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AV. HONORIO DELGADO 430 URB. INGENIERIA	LIMA		31		PER	International Research and Research Training	000	4	8/13/2018	NON-COMPETING CONTINUATION	$299,926
2018	2018	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AV. HONORIO DELGADO 430 URB. INGENIERIA	LIMA		31		PER	International Research and Research Training	002	4	9/19/2018	NON-COMPETING CONTINUATION	$49,647
														Subtotal = $349,573

Issue Date FY: 2017 ( Subtotal = $299,991 )
2017	2017	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AV. HONORIO DELGADO 430 URB. INGENIERIA	LIMA		31		PER	International Research and Research Training	001	3	9/22/2017	NON-COMPETING CONTINUATION	$0
2017	2017	UNIVERSIDAD PERUANA CAYETANO HEREDIA	AV. HONORIO DELGADO 430 URB. INGENIERIA	LIMA		31		PER	International Research and Research Training	000	3	8/24/2017	NON-COMPETING CONTINUATION	$299,991
														Subtotal = $299,991

Issue Date FY: 2016 ( Subtotal = $299,949 )
2016	2016	UNIVERSIDAD PERUANA CAYETANO	Av Honorio Delgado 430, Urb Ingenie	LIMA				PER	International Research and Research Training	000	2	8/15/2016	NON-COMPETING CONTINUATION	$299,949
														Subtotal = $299,949

Issue Date FY: 2015 ( Subtotal = $299,955 )
2015	2015	UNIVERSIDAD PERUANA CAYETANO	Av Honorio Delgado 430, Urb Ingenie	LIMA				PER	International Research and Research Training	000	1	9/24/2015	NEW	$299,955
														Subtotal = $299,955

Grand Total All Awards = $3,247,879

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1/2 - Regional GEOhealth Hub Centered In Peru-Peru

Award Number: U01TW010107

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/28/2015

PERIOD OF PERFORMANCE END DATE: 02/28/2027

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