Wednesday, July 9, 2025 7/9/2025

UDN Diagnostic Center of Excellence at Baylor College of Medicine

Award Number: U01NS134348
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2014
PERIOD OF PERFORMANCE END DATE: 07/31/2028

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UDN Diagnostic Center of Excellence at Baylor College of Medicine - PROJECT SUMMARY This is a continuation application for the Baylor College of Medicine (BCM) Diagnostic Center of Excellence (DCoE) of the Undiagnosed Diseases Network (UDN). In phase I and II of the UDN, we provided patients with undiagnosed diseases (UDD) access to state-of-the-art diagnostic methods, accelerated discovery of new biological mechanisms linking genetic variants with disease causation, identified potential treatment approaches, and engaged with the UDN and broader community to share best practices and innovations. We have implemented innovative technologies like RNA sequencing- “first” directed genomic analysis on both whole blood and fibroblasts to complement exome and genome sequencing. This RNAseq- first analytical approach is now widely used in the broader community. In the current bridge phase III year, we have established collaboration with other NIH (NCATS Project GIVE, NHGRI Texome, and All of Us Evenings with Genetics Scholars) and community health programs (Texas Association of Community Health Clinics) to increase referral of under-represented and underserved communities to our site. We achieved this by leveraging an integrated genetics program housed within the Department of Molecular and Human Genetics (DMHG). This includes a full spectrum of service, teaching, and research activities spanning from adult, pediatric, and prenatal care, to gene discovery and study of disease mechanisms to clinical trials, to a leading medical genetics diagnostic laboratory joint venture (Baylor Genetics), to community engagement via the DMHG Office of Community Engagement and Equity. We propose to continue this remarkably integrated approach to discovery and care to achieve the objectives of the phase III UDN with 1) expansion of our hybrid- 3rd party payor/research supported, tiered evaluations, 2) focus on under-represented and under-served populations referred by our NIH program/community partners, 3) efficiencies afforded by our virtual Consult a gene platform, 4) application of ultra-low cost sequencing in partnership with Ultima Genomics to empower newer multi-omic analyses, and 4) data and resource sharing widely via the UDN DMCC. The Specific Aims of this BCM UDN DCoE are to: 1) Expand and scale our current model of integrated, tiered clinical and research assessments that leverages institutional infrastructure, resources, and previous programmatic successes; 2) Expand UDN access to underserved and under-represented communities by expanding pilot activities established during the current phase III bridge year; 3) Extend on our innovative multi-omic approaches from phase I and II; 4) Implement initiatives and contribute to DMCC and network wide protocols and governance as we have successfully done in our phase I and II activities.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	10	3/6/2025	COMPETING CONTINUATION	$431,598
2025	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	3/6/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$287,732
2025	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	9	3/6/2025	SUPPLEMENT FOR EXPANSION	-$143,866
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $1,089,718 )
2024	2024	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	004	10	7/31/2024	COMPETING CONTINUATION	$794,101
2024	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	9	7/30/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2024	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	9	7/11/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	12/29/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$295,617
2024	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	9	7/30/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,089,718

Issue Date FY: 2023 ( Subtotal = $942,000 )
2023	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	9	4/27/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$628,000
2023	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	9	9/14/2023	SUPPLEMENT FOR EXPANSION	$314,000
														Subtotal = $942,000

Grand Total All Awards = $2,031,718

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UDN Diagnostic Center of Excellence at Baylor College of Medicine

Award Number: U01NS134348

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2014

PERIOD OF PERFORMANCE END DATE: 07/31/2028

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