Thursday, November 21, 2024 11/21/2024

Maximizing flexibility: Optimized neural probes and electronics for long term, high bandwidth recordings

Award Number: U01NS115588
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Abstract

The brain is a massively interconnected network of specialized circuits. Three characteristics of these circuits make them particularly challenging: diversity of time scales, diversity of spatial scales, and heterogeneity. Understanding the brain therefore requires spanning these temporal and spatial scales and providing information about cell-types. We need to be able to record the activity of individual neurons across time to understand activity patterns on a millisecond timescale and how those patterns evolve with experience across hours, days, months and even years. We need to be able to record throughout a cortical region, spanning both different parts of the region as well as all layers, to understand both local and distributed information processing. We also need to be able to combine these dense and distributed recordings with imaging to take advantage of the complementary strengths of electrical and optical measurements. This is hindered by multiple challenges: 1) Current approaches lack the spatial extent (spanning multiple structures) required to examine three-dimensional or distributed networks in detail. 2) Current electrophysiological approaches (which do provide the millisecond resolution) typically lack the necessary lifetime to follow long-term dynamics. 3) Current electrophysiological approaches use rigid electrodes that are ill-suited to use with imaging techniques. The overall objective of this project is to optimize a suite of complementary technologies that can address these challenges for the community and make them ready for common use by the neuroscience community. Our central hypothesis is that our recently developed nanoelectronic thread (NET) devices, which have demonstrated biocompatibility, in vivo function longevity, high quality unit recording and compatibility with optical methods, are a potentially ideal candidate for understanding patterns of brain activity. We plan to develop a selection of NET probes and high-density arrays that are suitable for multiple brain regions in different spices. We will engage expert neuroscientists, allowing us to develop and optimize NETs that work across mouse, rat and marmoset, and to expedite the delivery of resulting technologies to the scientific community. We will pursue the following three specific aims: 1) To optimize NET probes for various brain regions and species.; 2) To optimize NET probes for high-density regional and distributed recordings; and 3) To determine the best devices for each species and brain regions. The approach is innovative, because the technology we will develop and put into common use has the potential to drive innovation throughout the field, enabling new, very high density recording studies and allowing investigators to track large ensembles of neurons in unprecedented details and time duration.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	WILLIAM MARSH RICE UNIVERSITY	6100 MAIN ST	HOUSTON	TX	77005	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	11/8/2024	NON-COMPETING CONTINUATION	$0
2025	2021	WILLIAM MARSH RICE UNIVERSITY	6100 MAIN ST	HOUSTON	TX	77005	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	11/8/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	WILLIAM MARSH RICE UNIVERSITY	6100 MAIN ST	HOUSTON	TX	77005	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	3/1/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $1,133,684 )
2023	2023	WILLIAM MARSH RICE UNIVERSITY	6100 MAIN ST	HOUSTON	TX	77005	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	4	8/23/2023	SUPPLEMENT FOR EXPANSION	$65,316
2023	2023	WILLIAM MARSH RICE UNIVERSITY	6100 MAIN ST	HOUSTON	TX	77005	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	4	8/10/2023	SUPPLEMENT FOR EXPANSION	$35,306
2023	2023	WILLIAM MARSH RICE UNIVERSITY	6100 MAIN ST	HOUSTON	TX	77005	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	8/7/2023	NON-COMPETING CONTINUATION	$1,033,062
														Subtotal = $1,133,684

Issue Date FY: 2022 ( Subtotal = $1,207,675 )
2022	2022	WILLIAM MARSH RICE UNIVERSITY	6100 MAIN ST	HOUSTON	TX	77005	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	004	3	8/26/2022	SUPPLEMENT FOR EXPANSION	$70,610
2022	2022	WILLIAM MARSH RICE UNIVERSITY	6100 MAIN ST	HOUSTON	TX	77005	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	3	8/23/2022	NON-COMPETING CONTINUATION	$1,017,364
2022	2022	WILLIAM MARSH RICE UNIVERSITY	6100 MAIN ST	HOUSTON	TX	77005	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	3	8/25/2022	SUPPLEMENT FOR EXPANSION	$70,610
2022	2022	WILLIAM MARSH RICE UNIVERSITY	6100 MAIN ST	HOUSTON	TX	77005	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	5/13/2022	SUPPLEMENT FOR EXPANSION	$49,091
2022	2021	WILLIAM MARSH RICE UNIVERSITY	6100 MAIN ST	HOUSTON	TX	77005	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	8/12/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,207,675

Issue Date FY: 2021 ( Subtotal = $1,123,279 )
2021	2021	WILLIAM MARSH RICE UNIVERSITY	6100 MAIN ST	HOUSTON	TX	77005	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	1/21/2021	SUPPLEMENT FOR EXPANSION	$35,305
2021	2021	WILLIAM MARSH RICE UNIVERSITY	6100 MAIN ST	HOUSTON	TX	77005	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	8/20/2021	NON-COMPETING CONTINUATION	$1,017,364
2021	2021	WILLIAM MARSH RICE UNIVERSITY	6100 MAIN ST	HOUSTON	TX	77005	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	2	8/24/2021	SUPPLEMENT FOR EXPANSION	$70,610
														Subtotal = $1,123,279

Issue Date FY: 2020 ( Subtotal = $1,086,863 )
2020	2020	WILLIAM MARSH RICE UNIVERSITY	6100 MAIN ST	HOUSTON	TX	77005	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	8/19/2020	NEW	$1,086,863
														Subtotal = $1,086,863

Grand Total All Awards = $4,551,501

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Maximizing flexibility: Optimized neural probes and electronics for long term, high bandwidth recordings

Award Number: U01NS115588

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer