Wednesday, April 30, 2025 4/30/2025

Translational Development of Glial Growth Factor 2 (GGF2) for the Treatment of St

Award Number: U01NS076474
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Description

Translational Development of Glial Growth Factor 2 (GGF2) for the Treatment of St - DESCRIPTION (provided by applicant): Abstract Approximately 800,000 individuals suffer a stroke each year in the United States. Development of Glial Growth Factor 2 (GGF2) for promotion of stroke recovery is significant because of the lack of therapeutics to treat stroke. GGF2 also has a very wide treatment window (days) because it is not dependent upon neuroprotection. Additionally, as GGF2 is already in clinical trials for another indication, barries to manufacturing, formulation and toxicology have either been eliminated, or greatly reduced. The innovative aspect of this application comes from leveraging the existing development work that has been completed with GGF2 for another indication to efficiently enable an IND for stroke. Expanding on a significant body of preclinical data, GGF2 dosing will be optimized in a rat middle cerebral artery occlusion (MCAO) stroke model. Studies will explore dose frequency, extended dose duration and determine permanence of effects. Additional toxicology will be performed to enable the specific dose regimen proposed for stroke. GGF2 efficacy will then be confirmed in an established non-human primate model of cortical ischemia using a gyrencephalic rhesus monkey model. This model emphasizes neurorecovery rather than lesion volume reduction. Dosing will begin 24 hours after ischemia and behavioral improvements will be followed for at least 8 weeks in both rat and monkey studies. Following completion of studies in rhesus monkey an IND will be filed with the FDA.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2017	TRUSTEES OF BOSTON UNIVERSITY	85 E NEWTON ST M-921	BOSTON	MA	02118	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	12/3/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2017	TRUSTEES OF BOSTON UNIVERSITY	85 E NEWTON ST M-921	BOSTON	MA	02118	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	1/9/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$286,700
2018	2016	ACORDA THERAPEUTICS, INC.	420 SAW MILL RIVER RD	ARDSLEY	NY	10502	WESTCHESTER	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	1/9/2018	NON-COMPETING CONTINUATION	-$286,700
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $386,985 )
2017	2017	TRUSTEES OF BOSTON UNIVERSITY	85 E NEWTON ST M-921	BOSTON	MA	02118	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	9/19/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$386,985
														Subtotal = $386,985

Issue Date FY: 2016 ( Subtotal = $889,977 )
2016	2016	ACORDA THERAPEUTICS, INC	420 SAW MILL RIVER ROAD	ARDSLEY	NY	10502	WESTCHESTER	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	9/2/2016	NON-COMPETING CONTINUATION	$889,977
														Subtotal = $889,977

Issue Date FY: 2015 ( Subtotal = $0 )
2015	2014	ACORDA THERAPEUTICS, INC	420 SAW MILL RIVER ROAD	ARDSLEY	NY	10502	WESTCHESTER	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	8/17/2015	NEW	$0
														Subtotal = $0

Issue Date FY: 2014 ( Subtotal = $476,872 )
2014	2014	ACORDA THERAPEUTICS, INC	420 SAW MILL RIVER ROAD	ARDSLEY	NY	10502	WESTCHESTER	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	9/12/2014	NEW	$476,872
														Subtotal = $476,872

Grand Total All Awards = $1,753,834

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Translational Development of Glial Growth Factor 2 (GGF2) for the Treatment of St

Award Number: U01NS076474

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer