Abstract
Pandemic fatigue—a phenomenon characterized by a demotivation to follow recommended protective behaviors
that emerges over time and is affected by one’s emotions, experiences and perceptions—threatens our ability
to end the COVID-19 pandemic. Waning vaccine-induced immunity, breakthrough infections, new variants, and
uncertainty all contribute to pandemic fatigue. These ongoing challenges highlight the importance of sustaining
COVID-19 mitigation strategies, including COVID-19 testing, over the long run to achieve pandemic control.
While pandemic fatigue is an expected and natural response to a prolonged public health crisis, it compromises
our ability to keep members of underserved and medically and/or socially vulnerable populations safe, including
African Americans. Given that complete eradication or elimination are not feasible, scientists and public health
officials are focused on control measures to make COVID-19 endemic. To achieve endemic status, we must
identify and address barriers to COVID-19 testing within vulnerable populations, including pandemic fatigue.
Moreover, we must advance communication science interventions that enable us to determine how variations in
the presentation of messages targeting perceived risk for COVID-19 can be leveraged to increase motivation for
COVID-19 testing behaviors, and employ effective communication strategies to mitigate the impact of exposure
to misinformation on testing acceptance and uptake. Guided by the Capability Opportunity Motivation—Behavior
and Minority Health and Health Disparities Research Frameworks, this study will leverage participatory research
methods, artificial intelligence, and infrastructure from ongoing community-engaged COVID-19 mitigation
research to: 1) Host a design-a-thon to develop deep learning computer animations capable of conveying the
importance of COVID-19 testing and promoting its uptake in community settings among African Americans in
NC. 2) Determine whether a deep learning computer animation intervention (vs a control) improves COVID-19
testing uptake using a 1:1 randomized experiment. Study results will identify effective COVID-19 testing
promotion messages for African Americans with the potential for generalization to other key populations.
