Thursday, December 26, 2024 12/26/2024

Enhanced Surveillance for New Vaccine Preventable Diseases

Award Number: U01IP001059
ORGANIZATION: NATIONAL CENTER FOR IMMUNIZATION AND RESPIRATORY DISEASES(NCIRD)
OPDIV: CDC
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY ABSTRACT FOR THE NVSN CORE The purpose of this project is to support a network of US pediatric institutions to conduct prospective, active surveillance in defined inpatient and emergency department (ED) populations for acute gastroenteritis (AGE) and acute respiratory illnesses (ARI) and in asymptomatic healthy controls for evaluation of disease burden and annual estimates of influenza and rotavirus vaccine effectiveness (VE). The results from this program will be used to inform vaccine recommendations and assess the public health impact of the US rotavirus and influenza vaccination programs and provide epidemiologic data for other infectious diseases with therapeutics and vaccines in development. A second purpose is to prospectively follow children from birth to age two for a natural history study of pathogens and immunologic factors related to symptomatic and asymptomatic infection. Our proposal for this study is provided separately as an Optional Component. The first objective is to evaluate the effectiveness and impact of current or upcoming vaccines or other immunoprophylaxis strategies and to inform pediatric vaccine-related policies. This will be done through the AGE and ARI active surveillance program. The rotavirus and influenza vaccine programs will be evaluated. Children with AGE enrolled in the hospital and ED will have stool tested for rotavirus and rotavirus vaccine verification completed. Using a test-negative design, the vaccination status of children with laboratory- confirmed rotavirus will be compared to children testing negative for rotavirus to determine the effectiveness of rotavirus vaccines by age and vaccine type. Children > 6 months to 18 years of age hospitalized for ARI will be enrolled, nasal and throat swabs will be tested by influenza RT-PCR and vaccine verification will be completed. VE estimates will be made using a test-negative study design by age, vaccine type and influenza sub-types. The secondary objective is to actively assess the burden of AGE and ARI pathogens in pediatric hospital and ED populations using sensitive laboratory techniques on specimens collected during the 5 years of the project. A separate healthy control surveillance program will provide age and season frequency matched children for comparison to ill children for both AGE and ARI pathogens. Age- and pathogen-specific population-based estimates of incidence will be made by site and setting (hospital and ED). A third objective is to examine the epidemiologic, host and environmental factors that are relevant for public health interventions of vaccine preventable diseases and diseases in need of preventive or treatment strategies. This will be done through investigator-initiated proposals through the surveillance and optional component. This surveillance network and its associated activities will lead to high impact public health findings in the field of vaccine preventable diseases that will ultimately contribute to strategies to reduce the overall healthcare burden from these diseases and improve the health of the US population.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$97 )
2023	2020	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	06	5	1/4/2023	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2023	2019	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	06	5	1/4/2023	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2023	2018	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	06	5	1/4/2023	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2023	2017	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	06	5	1/4/2023	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2023	2016	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	05	5	12/20/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	-$97
2023	2016	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	06	5	1/4/2023	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = -$97

Issue Date FY: 2022 ( Subtotal = -$308,419 )
2022	2020	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	04	5	9/30/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	-$308,419
2022	2020	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	03	5	10/22/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2022	2019	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	04	5	9/30/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2022	2018	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	04	5	9/30/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2022	2017	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	04	5	9/30/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2022	2016	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	04	5	9/30/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = -$308,419

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	01	5	8/23/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2021	2020	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	02	5	9/1/2021	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $2,756,548 )
2020	2020	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	03	4	6/2/2020	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$562,720
2020	2020	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	00	5	7/31/2020	NON-COMPETING CONTINUATION	$2,193,828
2020	2019	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	03	4	6/2/2020	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2020	2019	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	02	4	12/20/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $2,756,548

Issue Date FY: 2019 ( Subtotal = $2,700,000 )
2019	2019	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 Burnet Ave	Cincinnati	OH	45229	HAMILTON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	00	4	7/17/2019	NON-COMPETING CONTINUATION	$2,450,000
2019	2019	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 Burnet Ave	Cincinnati	OH	45229	HAMILTON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	01	4	8/5/2019	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$250,000
														Subtotal = $2,700,000

Issue Date FY: 2018 ( Subtotal = $2,426,950 )
2018	2018	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	00	3	8/21/2018	NON-COMPETING CONTINUATION	$2,426,950
														Subtotal = $2,426,950

Issue Date FY: 2017 ( Subtotal = $2,200,000 )
2017	2017	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	002	2	8/7/2017	NON-COMPETING CONTINUATION	$2,200,000
2017	2016	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Prevention and Public Health Fund (Affordable Care Act): Enhanced Surveillance for New Vaccine Preventable Disease	001	1	6/27/2017	SUPPLEMENT FOR EXPANSION	$0
2017	2016	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	000	1	10/26/2016	NEW	$0
														Subtotal = $2,200,000

Issue Date FY: 2016 ( Subtotal = $2,199,997 )
2016	2016	CHILDREN`S HOSPITAL MEDICAL CENTER	3333 BURNET AVENUE	CINCINNATI	OH	45229	HAMILTON	USA	Immunization Research, Demonstration, Public Information and Education Training and Clinical Skills Improvement Projects	000	1	8/16/2016	NEW	$214,285
2016	2016	CHILDREN`S HOSPITAL MEDICAL CENTER	3333 BURNET AVENUE	CINCINNATI	OH	45229	HAMILTON	USA	Prevention and Public Health Fund (Affordable Care Act): Enhanced Surveillance for New Vaccine Preventable Disease	001	1	8/17/2016	SUPPLEMENT FOR EXPANSION	$1,985,712
														Subtotal = $2,199,997

Grand Total All Awards = $11,974,979

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Enhanced Surveillance for New Vaccine Preventable Diseases

Award Number: U01IP001059

ORGANIZATION: NATIONAL CENTER FOR IMMUNIZATION AND RESPIRATORY DISEASES(NCIRD)

OPDIV: CDC

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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