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Novel biological insights by utilizing mitochondrial genome information from HuBMAP resources

Award Number: U01HL166058
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2022
PERIOD OF PERFORMANCE END DATE: 06/30/2026

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Novel biological insights by utilizing mitochondrial genome information from HuBMAP resources - PROJECT SUMMARY Although typical scRNA-seq or scATAC-seq data contain 5-25% of reads that map to the mitochondrial DNA (mtDNA) genome, such mtDNA mapped reads are often filtered out or ignored during downstream analysis. The mitochondria generate over 90% of the cellular energy and are central to health and disease. mtDNA mutations directly cause mitochondrial disease. In addition, random somatic mtDNA mutations accumulate with age and are associated with a broad range of aging-related diseases such as immune disorders, cardiovascular disease and neurodegeneration. However, little is understood about whether accumulation of specific mtDNA variants during aging occurs at the same rate across different cell types, organs, age, gender and race. Such insights would substantially improve our understanding of how mtDNA mutations contribute to various human diseases. Accordingly, significant gaps of knowledge in the single-cell biology field include the lack of robust mtDNA analysis tools and how to utilize the rich mtDNA information often neglected in the ever-increasing datasets to obtain new biological insights. We propose to address these knowledge gaps by: (1) develop robust mtDNA analysis workflows and tools integrated with the HuBMAP Portal; (2) systemically analyze mtDNA from single- cell datasets generated by HuBMAP and other resources; (3) determine whether and how prevalent human mtDNA variants impact mitochondrial and cellular function.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $492,318 )
2025	2025	THE CHILDREN'S HOSPITAL OF PHILADELPHIA	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cardiovascular Diseases Research	001	4	5/14/2025	NON-COMPETING CONTINUATION	$492,318
2025	2024	THE CHILDREN'S HOSPITAL OF PHILADELPHIA	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cardiovascular Diseases Research	000	3	3/26/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $492,318

Issue Date FY: 2024 ( Subtotal = $505,417 )
2024	2024	THE CHILDREN'S HOSPITAL OF PHILADELPHIA	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cardiovascular Diseases Research	000	3	5/30/2024	NON-COMPETING CONTINUATION	$505,417
2024	2023	THE CHILDREN'S HOSPITAL OF PHILADELPHIA	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Trans-NIH Research Support	001	2	6/6/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $505,417

Issue Date FY: 2023 ( Subtotal = $617,577 )
2023	2023	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Trans-NIH Research Support	001	2	9/7/2023	SUPPLEMENT FOR EXPANSION	$100,000
2023	2023	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cardiovascular Diseases Research	000	2	6/3/2023	NON-COMPETING CONTINUATION	$517,577
														Subtotal = $617,577

Issue Date FY: 2022 ( Subtotal = $528,000 )
2022	2022	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Trans-NIH Research Support	000	1	6/21/2022	NEW	$528,000
														Subtotal = $528,000

Grand Total All Awards = $2,143,312

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Novel biological insights by utilizing mitochondrial genome information from HuBMAP resources

Award Number: U01HL166058

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2022

PERIOD OF PERFORMANCE END DATE: 06/30/2026

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