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UAB-MISS MACS/WIHS Combined Cohort Study

Award Number: U01HL146192
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2019
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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UAB-MISS MACS/WIHS Combined Cohort Study - As the HIV epidemic has matured, understanding the impact of HIV on overall health becomes more important as HIV is managed as a chronic illness. This is particularly true in the Southeastern part of the United States, where the epidemic is worsening relative to other parts of the country. Alabama and Mississippi are located in the heart of the Deep South and have some of the highest rates of new HIV cases annually, especially among minorities. Barriers to access to care are among the worst in the US, and the prevalence of obesity, cardiovascular disease, cancer, and health care disparities are most pronounced. Therefore, studying people living with HIV in the Deep South will provide the opportunity to understand the current epidemic as it is emerging today. The University of Alabama at Birmingham (UAB) has a rich tradition of AIDS research, dating back to the mid-1980s. As the epidemic has matured, UAB scientists have established expertise in many areas, including psychosocial/behavioral, neurocognition, aging, cancer, pathogenesis, and health disparities. UAB scientists have emerged as leaders in innovative cohort research that evaluates the long-term outcomes via multisite cohort studies (e.g., CNICS, NA-ACCORD, ART-CC, and FRAM). By creating a linkage to the University of Mississippi Medical Center (UMMC) as a subaward partner, we take full advantage of their years of expertise in HIV clinical care, outreach, and cohort research. Collectively, we represent an ideal cohort for the MACS/WIHS Combined Cohort Study (CCS), both in terms of scientific expertise and representation of the current HIV epidemic in the US. The Specific Aims for our CCS site are: 1. To continue to provide scientific leadership and expertise within the CCS, focusing on psychosocial/behavioral, structural and genetic determinants of HIV and co-morbidity-related outcomes; neurocognition among aging PLWH; and immunopathogenesis of HIV disease. 2. To collect high-quality data and specimens from MACS/WIHS-CCS core and sub-study visits to contribute to the Unified Scientific Agenda (USA) and protocols; and collaborate with the overall team of MACS/WIHS-CCS investigators across sites. 3. To continue to achieve operational excellence by maintaining outstanding records for recruitment, retention, data quality and completeness and cost-effectiveness. 4. To ensure sharing of data/specimens with the data center, the NIH community and external investigators, and communication/engagement with local communities. 5. To develop, mentor and support junior and minority investigators in coordination with Developmental Award Advisory Committee (DARC). 6. To recruit and retain a cohort of 230 women and 270 men, HIV-positive and age-matched HIV- negative controls, who are strategically selected to enable the conduct of the USA.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,631,927 )
2025	2025	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	001	7	3/28/2025	NON-COMPETING CONTINUATION	$2,631,927
2025	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	000	6	12/18/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,631,927

Issue Date FY: 2024 ( Subtotal = $2,857,804 )
2024	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	001	6	5/21/2024	NON-COMPETING CONTINUATION	$2,857,804
2024	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	000	5	10/28/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,857,804

Issue Date FY: 2023 ( Subtotal = $2,918,360 )
2023	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	001	5	5/3/2023	NON-COMPETING CONTINUATION	$0
2023	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	000	5	4/24/2023	NON-COMPETING CONTINUATION	$2,918,360
														Subtotal = $2,918,360

Issue Date FY: 2022 ( Subtotal = $2,954,063 )
2022	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	001	4	4/21/2022	NON-COMPETING CONTINUATION	$2,954,063
2022	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	000	3	10/12/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,954,063

Issue Date FY: 2021 ( Subtotal = $2,947,093 )
2021	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	002	3	8/22/2021	SUPPLEMENT FOR EXPANSION	$33,629
2021	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	001	3	3/12/2021	NON-COMPETING CONTINUATION	$2,913,464
2021	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	000	2	11/25/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,947,093

Issue Date FY: 2020 ( Subtotal = $3,170,433 )
2020	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	005	2	8/15/2020	SUPPLEMENT FOR EXPANSION	$30,550
2020	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	002	2	5/11/2020	NON-COMPETING CONTINUATION	$0
2020	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	001	2	4/10/2020	NON-COMPETING CONTINUATION	$2,863,446
2020	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	007	2	9/10/2020	SUPPLEMENT FOR EXPANSION	$59,585
2020	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	006	2	8/25/2020	SUPPLEMENT FOR EXPANSION	$178,607
2020	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	003	2	5/29/2020	NON-COMPETING CONTINUATION	$0
2020	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	004	2	6/17/2020	SUPPLEMENT FOR EXPANSION	$38,245
2020	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	000	1	3/19/2020	NEW	$0
														Subtotal = $3,170,433

Issue Date FY: 2019 ( Subtotal = $2,807,649 )
2019	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	001	1	4/18/2019	NEW	$0
2019	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	000	1	3/29/2019	NEW	$2,400,000
2019	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	003	1	9/16/2019	SUPPLEMENT FOR EXPANSION	$38,470
2019	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Cardiovascular Diseases Research	002	1	9/12/2019	SUPPLEMENT FOR EXPANSION	$369,179
														Subtotal = $2,807,649

Grand Total All Awards = $20,287,329

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UAB-MISS MACS/WIHS Combined Cohort Study

Award Number: U01HL146192

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2019

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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