Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Population Genomic Screening in Primary Care

Award Number: U01HG014610
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/14/2026
PERIOD OF PERFORMANCE END DATE: 02/28/2031

Group Awards By:

View Award Description

Population Genomic Screening in Primary Care - Despite advances in our understanding of genetic basis of disease risk and advances in technology enabling genomic risk assessment, implementation of genomic medicine is limited. Many individuals at risk for common, actionable genetic conditions remain undiagnosed and most are unaware of their risk. Population genomic screening offers the opportunity to address these gaps by enabling early detection and intervention. Incorporating genomic screening into primary care could transform chronic disease prevention. To generate evidence on feasibility, clinical utility, and impact on health, working with our community stakeholders, we will develop and implement a pilot program for population genomic screening for common, actionable genetic conditions in primary care. In collaboration with the network, we will select conditions for which genomic screening can have a high-impact and strong evidence of preventing or mitigating disease severity. We propose screening for the three Centers for Disease Control and Prevention (CDC) Tier1 conditions (hereditary breast and ovarian cancer, Lynch syndrome, and familial hypercholesterolemia) and three additional conditions (Transthyretin amyloidosis, Hypertrophic cardiomyopathy, and APOL1 hypertensive renal disease) each chosen due to their particular significance in our patients and communities. We will engage stakeholders (PCPs, clinic staff participants, community members) to inform implementation and evaluation of genomic screening. We will develop a network-wide protocol to deploy the population genomic screening for the selected conditions in 5000 participants at our site (20,000 across the network). We will return results to the provider and participant and assess adoption of recommendations. Finally, we will evaluate participant outcomes over 24 months and examine the impact of the chosen implementation strategies on the adoption and integration of population genomic screening in primary care and share the implementation framework for population genomic screening in primary care. We bring together a team of national leaders with expertise in chronic disease genomics, clinical genetics, cancer genetics, cardiogenomics, implementation science, community engagement, and clinical informatics to translate genomic insights into clinical care. In collaboration with the community, clinical stakeholders, and the network, we will establish best practices for broader adoption of population genomic screening in primary care.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $831,462 )
2026	2026	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Human Genome Research	000	1	4/27/2026	NEW	$831,462
														Subtotal = $831,462

Grand Total All Awards = $831,462

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Population Genomic Screening in Primary Care

Award Number: U01HG014610

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/14/2026

PERIOD OF PERFORMANCE END DATE: 02/28/2031

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer