Wednesday, March 11, 2026 3/11/2026

Comprehensive Polygenic Risk Profiling Across Multiple Health Outcomes (CARDINAL)

Award Number: U01HG011717
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/08/2021
PERIOD OF PERFORMANCE END DATE: 03/31/2027

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Comprehensive Polygenic Risk Profiling Across Multiple Health Outcomes (CARDINAL) - Non-communicable conditions such as type 2 diabetes and hypertension; breast and cervical cancer; and infections like human papillomavirus that elevate malignancy risk comprise a significant share of illness and death in the United States. Traditional risk models rely on family history and clinical measures but often miss the full spectrum of inherited variation. Polygenic risk scores (PRSs) integrate thousands of genetic variants to quantify individual susceptibility, yet many scores lose precision when applied outside their original development cohort. The Comprehensive Polygenic Risk Profiling Across Multiple Health Outcomes (CARDINAL) Study Site will merge high-quality genomic data with health records, laboratory results, and longitudinal follow-up for more than 50,000 adults enrolled through US research initiatives. By harmonizing quality-controlled genotypes with richly annotated phenotype data, CARDINAL will enable a rigorous evaluation of existing PRSs for metabolic traits, infection-associated cancer risk, and hormone-driven malignancies. We will implement advanced statistical and machine-learning pipelines that adjust for genetic substructure, local ancestry, and gene- environment interactions, refining risk models to improve calibration and reclassification in real-world patient cohorts. Innovative tools will map individual and aggregate risk distributions, highlight PRS performance relative to conventional predictors, and facilitate rigorous comparisons of modeling strategies. Through collaborative partnerships with national research consortia and healthcare networks, CARDINAL will create an open system for sharing summary results, analysis code, and reporting guidelines. By developing, validating, and disseminating robust PRS tools within a U.S. healthcare context, CARDINAL aims to accelerate the incorporation of genetic risk assessment into routine clinical workflows, support risk-tailored intervention strategies, and ultimately reduce the burden of common chronic diseases, hormone-related cancers, and infection-associated malignancies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	UNIVERSITY OF MARYLAND, BALTIMORE	220 ARCH ST OFC LEVEL2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Human Genome Research	001	5	2/25/2026	NON-COMPETING CONTINUATION	$0
2026	2025	UNIVERSITY OF MARYLAND, BALTIMORE	220 ARCH ST OFC LEVEL2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Human Genome Research	000	5	1/7/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $885,636 )
2025	2025	UNIVERSITY OF MARYLAND, BALTIMORE	220 ARCH ST OFC LEVEL2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Human Genome Research	000	5	7/3/2025	NON-COMPETING CONTINUATION	$885,636
														Subtotal = $885,636

Issue Date FY: 2024 ( Subtotal = $901,157 )
2024	2024	UNIVERSITY OF MARYLAND, BALTIMORE	220 ARCH ST OFC LEVEL2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Human Genome Research	001	4	5/28/2024	NON-COMPETING CONTINUATION	$73,562
2024	2024	UNIVERSITY OF MARYLAND, BALTIMORE	220 ARCH ST OFC LEVEL2	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Human Genome Research	000	4	4/4/2024	NON-COMPETING CONTINUATION	$827,595
														Subtotal = $901,157

Issue Date FY: 2023 ( Subtotal = $935,153 )
2023	2023	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Human Genome Research	001	3	3/21/2023	NON-COMPETING CONTINUATION	$935,153
2023	2022	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Human Genome Research	000	2	10/21/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $935,153

Issue Date FY: 2022 ( Subtotal = $950,311 )
2022	2022	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Human Genome Research	001	2	4/18/2022	NON-COMPETING CONTINUATION	$950,311
2022	2021	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Human Genome Research	000	1	12/17/2021	NEW	$0
														Subtotal = $950,311

Issue Date FY: 2021 ( Subtotal = $958,531 )
2021	2021	UNIVERSITY OF MARYLAND	220 ARCH ST RM 02148	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Human Genome Research	000	1	6/8/2021	NEW	$958,531
														Subtotal = $958,531

Grand Total All Awards = $4,630,788

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Comprehensive Polygenic Risk Profiling Across Multiple Health Outcomes (CARDINAL)

Award Number: U01HG011717

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/08/2021

PERIOD OF PERFORMANCE END DATE: 03/31/2027

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