Thursday, July 3, 2025 7/3/2025

UCLA clinical site for the investigation of undiagnosed disorders

Award Number: U01HG007703
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2014
PERIOD OF PERFORMANCE END DATE: 04/30/2023

Group Awards By:

View Award Description

UCLA clinical site for the investigation of undiagnosed disorders - Project Summary / Abstract Undiagnosed diseases take a disproportionate toll on the health care system and on affected patients and families. This second Administrative Supplement for 08/05/22-06/30/23 for the UCLA Clinical Site of the UDN is specifically to support re-initiation of ongoing recruitment, case evaluations pre-acceptance, determination of acceptance, and enrollment/consenting of the affected individual and relevant family members as well as clinical evaluation using the sustainable clinic approach with data return and wrap-up for 15 new UDN participants. This proposal is organized relative to a concurrent administrative supplement without budgetary overlap. We are poised to restart enrollment by 09/01/22, and complete evaluations by 6/30/22. This funding will allow the UCLA clinical site to cover research related costs for new enrollees. Our sustainable clinic model at UCLA will use the administrative supplement to provide for some of the costs associated with basic and clinical data collection related to the new enrollments, and clinical evaluations will be billed to patient insurance. This results in an improved diagnostic process for undiagnosed diseases. Investigating rare diseases involving multiple systems and incorporating comprehensive genomic data into clinical care creates considerable challenges, from the interpretation of vast amounts of genetic variants to their relevance to the symptoms, to the communication issues linked to their disclosure, and to their impact on clinical management. The Second Administrative Supplement of the UCLA Clinical Site of the UDN will support the ongoing communications with applicants, review of medical records, case discussion, acceptance decisions and communications, case evaluation at UCLA by telemedicine or in person within UCLA Health clinics and with insurance billing and patient co-pay, with coverage of research structure and research testing from NIH funds including a combination of a previously approved Administrative Supplement, this second supplement request, and a carryforward request from prior year unobligated balance. We continue to reach these overarching goals by implementing the following specific aims: Aim 1: Implement a UDN clinic model that functions locally and network-wide; Aim 2: Investigate the clinical phenotypes of new and rare disorders; Aim 3: Investigate the underlying mechanisms of new and rare disorders; Aim 4: Build a network-wide sustainable infrastructure for translational research on new and rare disorders


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$393,138 )
2024	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Trans-NIH Research Support	000	8	12/5/2023	SUPPLEMENT FOR EXPANSION	-$200,791
2024	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Trans-NIH Research Support	001	8	12/5/2023	SUPPLEMENT FOR EXPANSION	-$192,347
														Subtotal = -$393,138

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Trans-NIH Research Support	002	8	4/25/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Trans-NIH Research Support	001	8	4/25/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Trans-NIH Research Support	000	8	4/25/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $632,439 )
2022	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Trans-NIH Research Support	002	8	9/20/2022	SUPPLEMENT FOR EXPANSION	$192,347
2022	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Trans-NIH Research Support	001	8	6/28/2022	SUPPLEMENT FOR EXPANSION	$440,092
2022	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Trans-NIH Research Support	000	8	2/8/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $632,439

Issue Date FY: 2021 ( Subtotal = $550,000 )
2021	2021	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Trans-NIH Research Support	004	8	7/1/2021	NON-COMPETING CONTINUATION	$550,000
2021	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Human Genome Research	000	6	10/19/2020	NON-COMPETING CONTINUATION	$0
2021	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Human Genome Research	002	5	5/17/2021	COMPETING CONTINUATION	-$903,547
2021	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Trans-NIH Research Support	003	4	5/17/2021	SUPPLEMENT FOR EXPANSION	$383,333
2021	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Human Genome Research	006	5	7/20/2021	COMPETING CONTINUATION	$982,325
2021	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Trans-NIH Research Support	007	4	7/20/2021	SUPPLEMENT FOR EXPANSION	-$383,333
2021	2017	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Trans-NIH Research Support	005	4	7/20/2021	NON-COMPETING CONTINUATION	-$598,992
2021	2017	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Trans-NIH Research Support	001	4	5/17/2021	NON-COMPETING CONTINUATION	$520,214
														Subtotal = $550,000

Issue Date FY: 2020 ( Subtotal = $550,000 )
2020	2020	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Trans-NIH Research Support	000	7	7/24/2020	NON-COMPETING CONTINUATION	$550,000
														Subtotal = $550,000

Issue Date FY: 2019 ( Subtotal = $750,000 )
2019	2019	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Human Genome Research	003	6	6/28/2019	NON-COMPETING CONTINUATION	$750,000
2019	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Human Genome Research	002	5	12/28/2018	COMPETING CONTINUATION	$903,547
2019	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Trans-NIH Research Support	001	4	12/27/2018	SUPPLEMENT FOR EXPANSION	-$383,333
2019	2017	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Trans-NIH Research Support	000	4	12/27/2018	NON-COMPETING CONTINUATION	-$520,214
														Subtotal = $750,000

Issue Date FY: 2018 ( Subtotal = $1,133,333 )
2018	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Human Genome Research	003	5	9/25/2018	COMPETING CONTINUATION	$0
2018	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Trans-NIH Research Support	001	4	3/30/2018	SUPPLEMENT FOR EXPANSION	$383,333
2018	2018	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Human Genome Research	002	5	9/21/2018	COMPETING CONTINUATION	$750,000
2018	2017	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Trans-NIH Research Support	000	4	3/30/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,133,333

Issue Date FY: 2017 ( Subtotal = $1,982,437 )
2017	2017	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90095	LOS ANGELES	USA	Trans-NIH Research Support	000	4	3/27/2017	NON-COMPETING CONTINUATION	$1,982,437
														Subtotal = $1,982,437

Issue Date FY: 2016 ( Subtotal = $2,056,746 )
2016	2016	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Trans-NIH Research Support	001	3	9/8/2016	SUPPLEMENT FOR EXPANSION	$56,000
2016	2016	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Trans-NIH Research Support	000	3	3/31/2016	NON-COMPETING CONTINUATION	$2,000,746
														Subtotal = $2,056,746

Issue Date FY: 2015 ( Subtotal = $1,650,487 )
2015	2015	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Trans-NIH Research Support	000	2	6/5/2015	NON-COMPETING CONTINUATION	$1,650,487
														Subtotal = $1,650,487

Issue Date FY: 2014 ( Subtotal = $800,000 )
2014	2014	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Trans-NIH Research Support	000	1	6/30/2014	NEW	$800,000
														Subtotal = $800,000

Grand Total All Awards = $9,712,304

Top

All Categories

About

Search

Reports

Data Submission

Award Information

UCLA clinical site for the investigation of undiagnosed disorders

Award Number: U01HG007703

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2014

PERIOD OF PERFORMANCE END DATE: 04/30/2023

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer