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Quantifying Model Uncertainty for Forecasting the Spread of Infectious Diseases

Award Number: U01GM097658
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2011
PERIOD OF PERFORMANCE END DATE: 04/30/2017

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Quantifying Model Uncertainty for Forecasting the Spread of Infectious Diseases - DESCRIPTION (provided by applicant): The primary goal of our proposal is to enhance the nation's public health response capability by quantifying agent-based model uncertainty and the impact of behavioral modification on the spread of infectious diseases. Our goal is to improve the understanding of the impact of emergent behavior on the accuracy and applicability of predictive models of disease spread. We will evaluate the implications of uncertainty in human and population behavioral response to a pandemic in mathematical model formulations. This foundational understanding will help improve all existing epidemiological models thereby potentiating the ability of public health practitioners and policy-makers to effectively manage a burgeoning epidemic regardless of the tool being used. We will leverage existing epidemiologic and behavioral simulation infrastructure to develop new mathematical approaches to incorporate different types of diseases and behavioral changes alone and in combination with other intervention strategies. We will validate the models and quantify sensitivity of computational models to parameters, and known disease spread patterns. These models will be constructed for use in estimating prevalence and incidence and will allow us to compare systematically the relative effects of preventive measures, such as behavioral changes, isolation, contact tracing, quarantine, and vaccination. First, we will develop novel approaches to characterize emergent behavior and extend the mathematical foundation and software infrastructure for modeling behavior changes in response to an epidemic. Secondly, we will quantify the epidemic progression uncertainty caused by the distribution of behavioral responses. These behavioral models will be implemented and validated in an existing high-fidelity agent-based activity simulator model. Finally, we will disseminate these advances so they can be useful, and used, in other epidemiological simulations. RELEVANCE: The data for an ongoing epidemic is sparse, inexact, and often just unavailable. Therefore, quantifying parameter and computational uncertainties is crucial for forecasting the impact of disease spread. We cannot assume impact of the uncertain parameters is negligible; especially when decisions based on the model will impact the lives of countless people. One of the fundamental limitations of the current models is in how well they capture changes in human behavior in response to an ongoing endemic.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2015	LOS ALAMOS NATIONAL SECURITY, LLC	BIKINI ATOLL RD SM 30	LOS ALAMOS	NM	87545	LOS ALAMOS	USA	Biomedical Research and Research Training	000	5	11/27/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $669,667 )
2015	2015	LOS ALAMOS NATIONAL SECURITY LLC	4200 WEST JEMEZ ROAD	LOS ALAMOS	NM	87544	LOS ALAMOS	USA	Biomedical Research and Research Training	000	5	4/30/2015	NON-COMPETING CONTINUATION	$669,667
														Subtotal = $669,667

Issue Date FY: 2014 ( Subtotal = $669,667 )
2014	2014	LOS ALAMOS NATIONAL SECURITY LLC	4200 WEST JEMEZ ROAD	LOS ALAMOS	NM	87544	LOS ALAMOS	USA	Biomedical Research and Research Training	000	4	6/20/2014	NON-COMPETING CONTINUATION	$669,667
														Subtotal = $669,667

Issue Date FY: 2013 ( Subtotal = $646,230 )
2013	2013	LOS ALAMOS NATIONAL SECURITY LLC	4200 WEST JEMEZ ROAD	LOS ALAMOS	NM	87544	LOS ALAMOS	USA	Biomedical Research and Research Training	001	3	6/7/2013	NON-COMPETING CONTINUATION	$43,530
2013	2013	LOS ALAMOS NATIONAL SECURITY LLC	4200 WEST JEMEZ ROAD	LOS ALAMOS	NM	87544	LOS ALAMOS	USA	Biomedical Research and Research Training	000	3	5/1/2013	NON-COMPETING CONTINUATION	$602,700
														Subtotal = $646,230

Issue Date FY: 2012 ( Subtotal = $669,667 )
2012	2012	LOS ALAMOS NATIONAL SECURITY LLC	4200 WEST JEMEZ ROAD	LOS ALAMOS	NM	87544	LOS ALAMOS	USA	Biomedical Research and Research Training	000	2	5/30/2012	NON-COMPETING CONTINUATION	$669,667
														Subtotal = $669,667

Issue Date FY: 2011 ( Subtotal = $669,667 )
2011	2011	LOS ALAMOS NATIONAL SECURITY LLC	4200 WEST JEMEZ ROAD	LOS ALAMOS	NM	87544	LOS ALAMOS	USA	Biomedical Research and Research Training	000	1	5/31/2011	NEW	$669,667
														Subtotal = $669,667

Grand Total All Awards = $3,324,898

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Quantifying Model Uncertainty for Forecasting the Spread of Infectious Diseases

Award Number: U01GM097658

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2011

PERIOD OF PERFORMANCE END DATE: 04/30/2017

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