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Multidimensional in vivo Assessments of Engineered Nanomaterials and Biological Interactions

Award Number: U01ES027294
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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While nanotechnology has significant potential to address critical societal needs, innovators, policy makers and the public have concerns that the novel properties of engineered nanomaterials (ENMs) may cause harm. The number of new ENMs being generated is outpacing our efforts to understand the impacts of these materials. To advance our understanding and to keep pace with new innovations, we increasingly need advances in ENM synthesis, characterization, and bioactivity screening. Due to the complexity of this challenge, highly interactive multi-disciplinary teams are needed. We will collaborate with the Nanomaterials Health Implications Research (NHIR): Engineered Nanomaterials Resource and Coordination Core (ERCC). We expect that the NHIR will provide precision-engineered, multifunction ENMs to probe the roles of surface chemistry and core characteristics in function and properties. We propose that zebrafish offer unparalleled advantages to broadly interrogate the interactions between ENMs and biological systems. It is now widely accepted that data collected using the zebrafish model is readily translated to humans because of the genetic and molecular conservation between these species. More importantly, the unique inherent advantages of this model provides research opportunities not possible or feasible in other systems. For example, with a small quantity of test material, it is possible to determine whether a given ENM is able to interact with biological targets to produce molecular changes in the transcriptome, proteome and metabolome within the entire animal. Sensitivity of these `omic approaches” is very high and uncertainty is reduced since all cell types are assessed simultaneously in the whole zebrafish. Additionally, changes in growth, organ development, cardiovascular function, and complex neurobehavior are easily assessed at a high throughput. Over the past several years, we have developed a number of novel tools and assays to assess the impacts of ENMs on adult zebrafish and the microbiome to further increase the sensitivity of our multi-dimensional screens. In this proposal we will rapidly evaluate the bioimpacts of the provided materials using multi-dimensional, high throughput early life stage and adult zebrafish bioassays that we have pioneered. We will rapidly provide these comprehensive response profiles to the NHIR consortium. We will complete the following specific aims: 1) Define a comprehensive biological response profile produced by exposure to ENM using early life stage zebrafish; 2) Determine the long lasting impacts of early life stage exposure to ENMs; 3) Evaluate the impact of ingestion of ENMs on the microbiota in adult zebrafish; 4) Integrate ENM responses from the zebrafish and other biological systems to develop principles to reduce hazards. We expect that with completion of these proposed studies and through interactions and collaborations with the NHIR consortium, the expanded knowledge base of ENM-biological interactions will begin to reduce the uncertainty around ENM health risks. In so doing, we will progress toward the longer term goal to maximize the benefits and minimize the negative impacts of ENMs.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2020	OREGON STATE UNIVERSITY	1500 SW JEFFERSON AVE	CORVALLIS	OR	97331	BENTON	USA	Environmental Health	000	5	3/5/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	Environmental Health	000	5	12/22/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	Environmental Health	000	5	4/22/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $104,918 )
2021	2021	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	Environmental Health	001	5	8/11/2021	SUPPLEMENT FOR EXPANSION	$104,918
2021	2020	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	Environmental Health	000	5	8/10/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $104,918

Issue Date FY: 2020 ( Subtotal = $216,327 )
2020	2020	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	Environmental Health	000	5	9/1/2020	NON-COMPETING CONTINUATION	$216,327
														Subtotal = $216,327

Issue Date FY: 2019 ( Subtotal = $216,327 )
2019	2019	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	Environmental Health	000	4	8/19/2019	NON-COMPETING CONTINUATION	$216,327
														Subtotal = $216,327

Issue Date FY: 2018 ( Subtotal = $216,327 )
2018	2018	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	Environmental Health	000	3	8/27/2018	NON-COMPETING CONTINUATION	$216,327
														Subtotal = $216,327

Issue Date FY: 2017 ( Subtotal = $216,327 )
2017	2017	OREGON STATE UNIVERSITY	1500 SW JEFFERSON ST	CORVALLIS	OR	97331	BENTON	USA	Environmental Health	000	2	8/16/2017	NON-COMPETING CONTINUATION	$216,327
														Subtotal = $216,327

Issue Date FY: 2016 ( Subtotal = $219,999 )
2016	2016	OREGON STATE UNIVERSITY	OFFICE OF POST AWARD ADMINISTRATION	CORVALLIS	OR	97339	BENTON	USA	Environmental Health	000	1	9/13/2016	NEW	$219,999
														Subtotal = $219,999

Grand Total All Awards = $1,190,225

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Multidimensional in vivo Assessments of Engineered Nanomaterials and Biological Interactions

Award Number: U01ES027294

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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