Monday, March 16, 2026 3/16/2026

Prevention of LUTS: Bladder Health Clinical Center, UC San Diego Site

Award Number: U01DK106827
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2015
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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Prevention of LUTS: Bladder Health Clinical Center, UC San Diego Site - PROJECT SUMMARY/ABSTRACT The Prevention of Lower Urinary Tract Symptoms (PLUS) Consortium was established to lay the foundation necessary to study bladder health (BH) in women and girls, including the identification of risk and protective factors for BH using a longitudinal cohort. Factors identified across the spectrum of the PLUS conceptual model, from societal to biologic, will establish the evidence base for intervention studies designed by PLUS researchers and others in the field. The objective of this application is to present the UC San Diego Clinical Research Center (CRC) as a diverse, experienced, committed, and invaluable contributor to the Consortium. We will continue to provide the unique transdisciplinary expertise necessary for the Consortium to advance the study and promotion of BH. Members of our team have extensive experience in transdisciplinary research, epidemiology, longitudinal cohort studies, prevention science, public health, health education, cross cultural research, qualitative research, primary care (Pediatrics, Obstetrics & Gynecology), clinical care of women with LUTS, and are world renown for population-based microbiome research. We boast a history of strong leadership and critical contributions to the foundational work of the Consortium, including leadership in the development and validation of instruments for BH and qualitative research on the Study of Habits, Attitudes, Realities and Experiences (SHARE) and related knowledge, attitudes and beliefs (KAB). UC San Diego is a well-established research institution, funded by the National Institutes of Health, including a sponsored Clinical & Translational Science Award which provides a full spectrum of resources and personnel for the conduct of basic science, translational, epidemiologic, behavioral, and clinical research across the full age spectrum among racially and ethnically diverse communities. In addition to the foundational work of validating the bladder health instrument (BHI) for use in a culturally diverse population, our proposal incorporates cutting edge translational research aimed at identifying a healthy urogenital microbiome. The unique strengths of our application include: a) robust contributions to the foundational work of the Consortium including two team members actively engaged in the design of the planned longitudinal cohort study; b) a history of strong recruitment and retention of ethnically diverse participants for qualitative (SHARE), quantitative clinical trials and longitudinal cohort studies; c) a conceptual model centered around the notion that BH may be mediated through societal, institutional, interpersonal, behavioral and biologic factors via the urogenital microbiome; d) a feasibility pilot study of collection and analysis of voided urine specimens from a longitudinal cohort, which will foster investigations of prevention studies that manipulate the urogenital microbiome (directly or indirectly) through changes in modifiable risk factors across the PLUS conceptual framework; and e) the development of new measures for use in linguistically and culturally diverse populations starting with an adapted and validated Hispanic (English and Spanish language) BHI and KAB questionnaire.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$7 )
2026	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	11/26/2025	NON-COMPETING CONTINUATION	-$7
														Subtotal = -$7

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	1/8/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $462,208 )
2024	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	7/25/2024	NON-COMPETING CONTINUATION	$462,208
														Subtotal = $462,208

Issue Date FY: 2023 ( Subtotal = $437,508 )
2023	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	9	8/17/2023	NON-COMPETING CONTINUATION	$437,508
2023	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	8	3/29/2023	NON-COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	8	10/27/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $437,508

Issue Date FY: 2022 ( Subtotal = $580,000 )
2022	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	8	9/8/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	8	7/8/2022	NON-COMPETING CONTINUATION	$580,000
2022	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	7	3/31/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $580,000

Issue Date FY: 2021 ( Subtotal = $360,500 )
2021	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	7	7/20/2021	NON-COMPETING CONTINUATION	$360,500
2021	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	6	3/26/2021	COMPETING CONTINUATION	$294,727
2021	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	3/26/2021	NON-COMPETING CONTINUATION	-$294,727
														Subtotal = $360,500

Issue Date FY: 2020 ( Subtotal = $390,000 )
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	6	8/27/2020	COMPETING CONTINUATION	$390,000
2020	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	8/18/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $390,000

Issue Date FY: 2019 ( Subtotal = $441,075 )
2019	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	8/1/2019	NON-COMPETING CONTINUATION	$441,075
														Subtotal = $441,075

Issue Date FY: 2018 ( Subtotal = $262,554 )
2018	2018	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	8/8/2018	NON-COMPETING CONTINUATION	$262,554
														Subtotal = $262,554

Issue Date FY: 2017 ( Subtotal = $513,829 )
2017	2017	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	7/26/2017	NON-COMPETING CONTINUATION	$513,829
														Subtotal = $513,829

Issue Date FY: 2016 ( Subtotal = $513,334 )
2016	2016	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	7/15/2016	NON-COMPETING CONTINUATION	$513,334
														Subtotal = $513,334

Issue Date FY: 2015 ( Subtotal = $530,000 )
2015	2015	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	8/11/2015	NEW	$530,000
														Subtotal = $530,000

Grand Total All Awards = $4,491,001

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Prevention of LUTS: Bladder Health Clinical Center, UC San Diego Site

Award Number: U01DK106827

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2015

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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