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Expansion of Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN)

Award Number: U01DK099879
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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DESCRIPTION (provided by applicant): Lower urinary tract dysfunction (LUTD) is common, and its incidence and prevalence are increasing as the population ages. Symptoms of LUTD are costly to diagnose and treat; existing therapeutic interventions are neither highly effective nor durable and have side effects of their own. Not surprisingly, unsatisfactory outcomes from the patient perspective are common. Collectively, these challenges represent important targets of research that are consistent with the mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Previous efforts to improve patient reported outcomes (PRO) in this area have relied on incomplete symptom measurement scales and have been hampered by imperfect understanding of the origin and natural history of LUTD. Comprehensive re-evaluation of the symptom universe of LUTD and more precise characterization of patients with symptoms of LUTD (phenotyping) may provide significant new insights, leading ultimately to improved patient lives. The NIDDK-sponsored Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) includes a Data Coordinating Center (DCC) to serve as the project and data management nexus for the network. The purpose of this project is to expand the DCC, and increase the number of clinical sites that will enroll patients with symptoms of LUTD into carefully designed studies. There are three specific aims. The first is to expand the infrastructure of the LURN network to accommodate the addition of three to four clinical sites, plus the anticipated increase in complexity in supporting a larger consortium. The second specific aim is to enhance the collaboration between stakeholders by increasing the number of face-to-face meetings of the Steering Committee from one (currently) to three annually. The third aim is to expand the LURN consortium's patient-reported outcome measurement tools to include development and implementation of computerized adaptive testing.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2019 ( Subtotal = -$25 )
2019	2018	ARBOR RESEARCH COLLABORATIVE FOR HEALTH	340 E HURON ST STE 300	ANN ARBOR	MI	48104	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	9/6/2019	SUPPLEMENT FOR EXPANSION	-$25
														Subtotal = -$25

Issue Date FY: 2018 ( Subtotal = $135,000 )
2018	2018	ARBOR RESEARCH COLLABORATIVE FOR HEALTH	340 E HURON ST STE 300	ANN ARBOR	MI	48104	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	5/31/2018	SUPPLEMENT FOR EXPANSION	$135,000
														Subtotal = $135,000

Issue Date FY: 2017 ( Subtotal = $1,359,294 )
2017	2017	ARBOR RESEARCH COLLABORATIVE FOR HEALTH	340 E HURON ST STE 300	ANN ARBOR	MI	48104	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	5	6/19/2017	NON-COMPETING CONTINUATION	$609,255
2017	2017	ARBOR RESEARCH COLLABORATIVE FOR HEALTH	340 E HURON ST STE 300	ANN ARBOR	MI	48104	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	5	8/31/2017	SUPPLEMENT FOR EXPANSION	$750,039
2017	2016	ARBOR RESEARCH COLLABORATIVE FOR HEALTH	340 E HURON ST STE 300	ANN ARBOR	MI	48104	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	4	12/12/2016	EXTENSION WITH OR WITHOUT FUNDS	$623,637
2017	2015	ARBOR RESEARCH COLLABORATIVE FOR HEALTH	340 E HURON ST STE 300	ANN ARBOR	MI	48104	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	12/12/2016	NON-COMPETING CONTINUATION	-$623,637
														Subtotal = $1,359,294

Issue Date FY: 2016 ( Subtotal = $952,171 )
2016	2016	ARBOR RESEARCH COLLABORATIVE FOR HEALTH	315 WEST HURON STREET	ANN ARBOR	MI	48103	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	6/14/2016	EXTENSION WITH OR WITHOUT FUNDS	$302,242
2016	2016	ARBOR RESEARCH COLLABORATIVE FOR HEALTH	315 WEST HURON STREET	ANN ARBOR	MI	48103	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	4	9/12/2016	SUPPLEMENT FOR EXPANSION	$649,929
														Subtotal = $952,171

Issue Date FY: 2015 ( Subtotal = $691,767 )
2015	2015	ARBOR RESEARCH COLLABORATIVE FOR HEALTH	315 WEST HURON STREET	ANN ARBOR	MI	48103	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	5/13/2015	NON-COMPETING CONTINUATION	$691,767
														Subtotal = $691,767

Issue Date FY: 2014 ( Subtotal = $940,725 )
2014	2014	ARBOR RESEARCH COLLABORATIVE FOR HEALTH	315 WEST HURON STREET	ANN ARBOR	MI	48103	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	6/23/2014	NON-COMPETING CONTINUATION	$406,025
2014	2014	ARBOR RESEARCH COLLABORATIVE FOR HEALTH	315 WEST HURON STREET	ANN ARBOR	MI	48103	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	9/17/2014	SUPPLEMENT FOR EXPANSION	$534,700
														Subtotal = $940,725

Issue Date FY: 2013 ( Subtotal = $489,621 )
2013	2013	ARBOR RESEARCH COLLABORATIVE FOR HEALTH	315 West Huron	ANN ARBOR	MI	48103	WASHTENAW	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	7/23/2013	NEW	$489,621
														Subtotal = $489,621

Grand Total All Awards = $4,568,553

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Expansion of Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN)

Award Number: U01DK099879

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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