Thursday, November 21, 2024 11/21/2024

LURN II: Enhanced Characterization of Patients with LUTS Using Biopsychosocial Approaches

Award Number: U01DK097779
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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ABSTRACT This application is in response to PA-20-272: Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional). Summary of parent-award Specific Aims. The Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) was assembled in 2012 to increase the understanding of lower urinary tract symptoms (LUTS). Related to this goal was the improvement of patient-centered assessment of LUTS. This work involves improving the self-report measurement of LUTS using new, high-quality items to be used in questionnaire assessments. These items were created with qualitative input from patients, community participants, internists, urologists, urogynecologists, and clinical researchers. This set of items is referred to as the Comprehensive Assessment of Self-Reported Urinary Symptoms (CASUS). The original aims of the grant were Aim 1: To refine and expand a clinically-relevant cluster model across a cohort of patients with LUTS. Relative to LURN I, participants will have a wider range of symptom severity and be characterized using novel measures of bladder and urethral function; Aim 2: To identify protein biomarker signatures contained within plasma of specific subgroups of men and women with LUTS; Aim 3: To determine phenotypic characteristics of women with LUTS by measuring the functional components of the lower urinary tract; Aim 4 To validate comprehensive outcome tools for men and women with LUTS; and Aim 5: To determine influences of stress and mental health on LUTS. In this supplement, we will focus on the following additional activities: Aim 5.1. Determine the relationship between level of cognitive function and LUTS. LUTS increase with age and are associated with greater impairment in performing activities of daily living, lower mood, and poorer overall health quality. More recently, LUTS have been associated with increased risk of cognitive impairment and dementia. The LURN II data present a unique opportunity to further elucidate the relationship between cognition and LUTS. Within Aim 5.1, our hypothesis is: Cognitive function, measured by BrainTest, which is based on the electronic version of the self-administered gerocognitive examination (eSAGE), will be related to LUTS; Aim 5.2. Determine baseline predictors of LUTS trajectories in a sample of men and women with urinary urgency. We will conduct separate analyses in men and women who have urinary urgency and other LUTS. We propose to create models of the trajectory of LUTS for each participant, and then relating these trajectories to patient health variables. We will explore baselines symptoms, combined with other health variables that have been explored in LURN I such as BMI, depression, anxiety, and sleep disturbance. We also plan to explore psychosocial variables that have not been explored with respect to urgency: intolerance of uncertainty, catastrophizing, and adverse childhood experiences.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	11	10/21/2024	NON-COMPETING CONTINUATION	-$216,796
2025	2023	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	12	10/21/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$304,485
2025	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	10/21/2024	NON-COMPETING CONTINUATION	-$87,689
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $99,999 )
2024	2024	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	12	8/12/2024	SUPPLEMENT FOR EXPANSION	$99,999
2024	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	11	7/16/2024	NON-COMPETING CONTINUATION	-$249,397
2024	2023	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	12	7/17/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$249,397
2024	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	2/28/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $99,999

Issue Date FY: 2023 ( Subtotal = $466,193 )
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	11	8/21/2023	NON-COMPETING CONTINUATION	$466,193
														Subtotal = $466,193

Issue Date FY: 2022 ( Subtotal = $368,042 )
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	10	8/31/2022	NON-COMPETING CONTINUATION	$473,821
2022	2021	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	9	2/17/2022	NON-COMPETING CONTINUATION	-$105,779
														Subtotal = $368,042

Issue Date FY: 2021 ( Subtotal = $591,430 )
2021	2021	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	9	9/3/2021	NON-COMPETING CONTINUATION	$591,430
2021	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	8	12/16/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $591,430

Issue Date FY: 2020 ( Subtotal = $577,897 )
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	011	8	8/31/2020	NON-COMPETING CONTINUATION	$577,897
2020	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	7	12/12/2019	COMPETING CONTINUATION	$0
2020	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	006	7	2/6/2020	COMPETING CONTINUATION	-$3,046
2020	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	010	7	5/21/2020	COMPETING CONTINUATION	$0
2020	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	7	2/5/2020	COMPETING CONTINUATION	$3,046
2020	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	009	7	2/6/2020	COMPETING CONTINUATION	$101,619
2020	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	007	6	2/6/2020	NON-COMPETING CONTINUATION	-$51,571
2020	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	004	6	2/6/2020	NON-COMPETING CONTINUATION	$1,523
2020	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	005	6	2/6/2020	SUPPLEMENT FOR EXPANSION	$1,523
2020	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	008	6	2/6/2020	SUPPLEMENT FOR EXPANSION	-$50,048
2020	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	6	2/5/2020	SUPPLEMENT FOR EXPANSION	-$1,523
2020	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	6	2/5/2020	NON-COMPETING CONTINUATION	-$1,523
														Subtotal = $577,897

Issue Date FY: 2019 ( Subtotal = $525,453 )
2019	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	7	9/6/2019	COMPETING CONTINUATION	$525,453
2019	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	6	4/30/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $525,453

Issue Date FY: 2017 ( Subtotal = $446,849 )
2017	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	006	6	8/31/2017	SUPPLEMENT FOR EXPANSION	$50,048
2017	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	005	6	6/19/2017	NON-COMPETING CONTINUATION	$396,801
2017	2016	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	004	5	6/2/2017	EXTENSION WITH OR WITHOUT FUNDS	$0
2017	2016	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	5	11/18/2016	EXTENSION WITH OR WITHOUT FUNDS	$640,883
2017	2015	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	11/18/2016	NON-COMPETING CONTINUATION	-$386,250
2017	2015	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	4	11/18/2016	SUPPLEMENT FOR EXPANSION	-$166,219
2017	2014	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	3	11/18/2016	SUPPLEMENT FOR EXPANSION	-$88,414
														Subtotal = $446,849

Issue Date FY: 2016 ( Subtotal = $606,251 )
2016	2016	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	5	9/12/2016	SUPPLEMENT FOR EXPANSION	$220,001
2016	2016	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	6/14/2016	EXTENSION WITH OR WITHOUT FUNDS	$386,250
														Subtotal = $606,251

Issue Date FY: 2015 ( Subtotal = $552,469 )
2015	2015	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	4	9/15/2015	SUPPLEMENT FOR EXPANSION	$152,972
2015	2015	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	5/14/2015	NON-COMPETING CONTINUATION	$386,250
2015	2015	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	4	9/21/2015	SUPPLEMENT FOR EXPANSION	$13,247
														Subtotal = $552,469

Issue Date FY: 2014 ( Subtotal = $556,250 ) (Continued on the next page)
2014	2014	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	6/23/2014	NON-COMPETING CONTINUATION	$386,250
Grand Total All Awards = $5,563,635

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LURN II: Enhanced Characterization of Patients with LUTS Using Biopsychosocial Approaches

Award Number: U01DK097779

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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