Sunday, December 22, 2024 12/22/2024

Continuation of the Childhood Liver Disease Research Network - Seattle Clinical Center

Award Number: U01DK084575
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Biliary atresia (BA) and the other childhood cholestatic liver diseases are significant causes of chronic liver disease in children, and the leading causes for liver transplantation in pediatrics. The initial funding periods leading to the current Childhood Liver Disease Research Network (ChiLDReN) have resulted in unprecedented collections of well-phenotyped subjects, banked data, and biological specimens. Ongoing recruitment of subjects with these rare conditions is critical to allow full attainment to the Study Aims. Socioeconomic and ethnic diversity inclusion is crucial to support meaningful investigation into the pathogenesis of these diseases and the identification of generalizable management strategies. This next funding period will support these ongoing studies, which has broadened since the initial conception of this liver network from biliary atresia to include primary sclerosing cholangitis. The Seattle Children’s Clinical Center (CC) has the experience, expertise and proven track record essential for ongoing participation in ChiLDReN. Seattle Children’s has the expected volume of patients over time from a unique demographic spectrum, with indigenous populations inclusive of Alaska Natives and Native Hawaiians. We are well-poised to contribute outcome data for the participants enrolled in the legacy studies over the past 15 years with the variety of diseases studied by the ChiLDReN network. Furthermore, our enthusiastic recruitment strategies will be critical for the network as we focus on studying biliary atresia and primary sclerosing cholangitis. Our strong Center for Clinical and Translational Research has all the elements necessary to successfully support partnership with pharmaceutical companies or support additional ancillary studies that will complement the Network’s initiatives.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	16	12/4/2024	COMPETING CONTINUATION	$263,075
2025	2023	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	12/4/2024	NON-COMPETING CONTINUATION	-$263,075
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $300,000 )
2024	2024	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	16	6/25/2024	COMPETING CONTINUATION	$300,000
2024	2023	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	6/17/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $300,000

Issue Date FY: 2023 ( Subtotal = $355,000 )
2023	2023	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	5/30/2023	NON-COMPETING CONTINUATION	$355,000
														Subtotal = $355,000

Issue Date FY: 2022 ( Subtotal = $417,272 )
2022	2022	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	14	6/1/2022	NON-COMPETING CONTINUATION	$417,272
2022	2022	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	14	8/25/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $417,272

Issue Date FY: 2021 ( Subtotal = $398,570 )
2021	2021	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	13	5/26/2021	NON-COMPETING CONTINUATION	$398,570
2021	2019	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	11	3/8/2021	COMPETING CONTINUATION	$18,296
2021	2018	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	3/8/2021	NON-COMPETING CONTINUATION	-$18,296
														Subtotal = $398,570

Issue Date FY: 2020 ( Subtotal = $353,338 )
2020	2020	SEATTLE CHILDREN'S HOSPITAL	4800 SAND PT WAY NE	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	12	6/22/2020	NON-COMPETING CONTINUATION	$353,338
2020	2019	SEATTLE CHILDREN'S HOSPITAL	4800 SAND PT WAY NE	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	11	2/12/2020	COMPETING CONTINUATION	$22,364
2020	2018	SEATTLE CHILDREN'S HOSPITAL	4800 SAND PT WAY NE	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	2/12/2020	NON-COMPETING CONTINUATION	-$22,364
														Subtotal = $353,338

Issue Date FY: 2019 ( Subtotal = $203,000 )
2019	2019	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	11	9/17/2019	COMPETING CONTINUATION	$203,000
2019	2018	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	9/9/2019	NON-COMPETING CONTINUATION	$0
2019	2018	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	10	9/17/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $203,000

Issue Date FY: 2018 ( Subtotal = $261,999 )
2018	2018	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	7/2/2018	NON-COMPETING CONTINUATION	$261,999
														Subtotal = $261,999

Issue Date FY: 2017 ( Subtotal = $234,538 )
2017	2017	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	9	6/28/2017	NON-COMPETING CONTINUATION	$235,000
2017	2013	SEATTLE CHILDREN'S HOSPITAL	4800 SAND POINT WAY NE	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	5/11/2017	NON-COMPETING CONTINUATION	-$462
														Subtotal = $234,538

Issue Date FY: 2016 ( Subtotal = $275,000 )
2016	2016	SEATTLE CHILDREN`S HOSPITAL	4800 SAND POINT WAY NORTHEAST	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	8	7/13/2016	NON-COMPETING CONTINUATION	$275,000
														Subtotal = $275,000

Issue Date FY: 2015 ( Subtotal = $271,867 )
2015	2015	SEATTLE CHILDREN`S HOSPITAL	4800 SAND POINT WAY NORTHEAST	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	7	8/27/2015	NON-COMPETING CONTINUATION	-$8,133
2015	2015	SEATTLE CHILDREN`S HOSPITAL	4800 SAND POINT WAY NORTHEAST	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	7	8/12/2015	NON-COMPETING CONTINUATION	$280,000
														Subtotal = $271,867

Issue Date FY: 2014 ( Subtotal = $298,244 )
2014	2014	SEATTLE CHILDREN`S HOSPITAL	4800 SAND POINT WAY NORTHEAST	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	6	8/11/2014	COMPETING CONTINUATION	$298,244
2014	2013	SEATTLE CHILDREN`S HOSPITAL	4800 SAND POINT WAY NORTHEAST	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	8/6/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $298,244

Issue Date FY: 2013 ( Subtotal = $122,249 )
2013	2013	SEATTLE CHILDREN`S HOSPITAL	4800 SAND POINT WAY NORTHEAST	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	8/1/2013	NON-COMPETING CONTINUATION	$122,249
														Subtotal = $122,249

Issue Date FY: 2012 ( Subtotal = $170,996 )
2012	2012	SEATTLE CHILDREN`S HOSPITAL	4800 SAND POINT WAY NORTHEAST	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	9/14/2012	NON-COMPETING CONTINUATION	$170,996
														Subtotal = $170,996

Issue Date FY: 2011 ( Subtotal = $287,661 )
2011	2011	SEATTLE CHILDREN`S HOSPITAL	4800 SAND POINT WAY NORTHEAST	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	9/2/2011	NON-COMPETING CONTINUATION	$287,661
														Subtotal = $287,661

Issue Date FY: 2010 ( Subtotal = $333,340 )
2010	2010	SEATTLE CHILDREN`S HOSPITAL	4800 SAND POINT WAY NORTHEAST	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	7/29/2010	NON-COMPETING CONTINUATION	$333,340
														Subtotal = $333,340

Issue Date FY: 2009 ( Subtotal = $357,754 )
2009	2009	SEATTLE CHILDREN`S HOSPITAL	4800 SAND POINT WAY NORTHEAST	SEATTLE	WA	98105	KING	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	9/3/2009	NEW	$357,754
														Subtotal = $357,754

Grand Total All Awards = $4,640,828

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Continuation of the Childhood Liver Disease Research Network - Seattle Clinical Center

Award Number: U01DK084575

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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