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U of L Clinical Center to Investigate the Pathogenesis, Etiology, and Treatment of Gastroparesis through the NIDDK Gastroparesis Consortium

Award Number: U01DK074007
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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U of L Clinical Center to Investigate the Pathogenesis, Etiology, and Treatment of Gastroparesis through the NIDDK Gastroparesis Consortium - Gastroparesis is a disorder of gastric function characterized by delay in gastric emptying, frequently associated with chronic nausea and vomiting, early satiety, postprandial fullness, abdominal pain, and malnutrition that may require nutritional support. Gastroparesis has a devastating impact on quality of life and predominantly affects younger women. In the past 5 years, the Gastroparesis Clinical Research Consortium (GpCRC) has made a series of important contributions (see below) to improve our understanding of this disorder and advancing the goals of patients, physicians and the NIH for management of gastroparesis. Yet, much remains to be learned about its etiology, natural history, treatment strategies, and clinical course, which is the rationale behind our response to the Continuation of the Gastroparesis Consortium. The biggest barrier to effective therapeutic approaches to gastroparesis is our lack of knowledge about either its pathogenesis or its pathophysiology. Further, the correlation between the major symptoms such as nausea, vomiting, pain, and current methods to measure change in gastric function (electrical, motor activity, meal emptying times) is poor at best. Finally, we do not understand the long-term outcomes of these patients and whether outcomes differ on the basis of etiology, symptom severity, and degree of emptying abnormalities. Consequently, our approach to these patients is erratic and treatment has been empirical and only partially effective, if at all, in relieving the major symptoms. The mission of the GpCRC is completely aligned with the recommendations of the National Commission on Digestive Diseases: specifically, Research Goal 2.6 relates to gastroparesis and states: "Understand the noxious visceral signaling causing nausea and vomiting related to gastric neuro-electrical and/or motor dysfunction and the bi-directional brain-gut interactions. Gastroparesis provides an archetypal disease for investigative inquiry. Chronic vomiting, a debilitating and socially isolating digestive symptom, creates potentially life-threatening disruptions in fluid and electrolyte homeostasis and compromises nutritional status. Chronic nausea remains a significant hidden disability. Nausea and vomiting usually occur in tandem and overlay with other Gl symptoms as well as presenting in numerous digestive diseases. More effective treatments for nausea and vomiting would improve quality of life and physical functioning in a vast array of illnesses. A paucity of research exists for defining peripheral noxious signaling of nausea and vomiting related to primary Gl motor/sensory disturbances." The Specific Aims of this proposal are to: 1. Complete the current GpCRC registry (Registry Three); 2. Extend the GpCRC core lab, responsible for anatomic and related studies on tissue samples of patients with Gp syndromes; 3. Perform pharmacologic studies on patients with Gp syndromes.; 4. Perform a new device/pyloric intervention study protocol for patients with the Gp syndromes; and 5. Utilize several novel approaches to some of the unmet needs in patients with gastroparesis symptoms, which could be incorporated in new studies of the Consortium.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $366,074 )
2024	2024	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	18	7/31/2024	NON-COMPETING CONTINUATION	$366,074
														Subtotal = $366,074

Issue Date FY: 2023 ( Subtotal = $377,701 )
2023	2023	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	17	8/29/2023	NON-COMPETING CONTINUATION	$377,701
2023	2022	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	16	8/28/2023	COMPETING CONTINUATION	$420,633
2023	2020	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	15	8/28/2023	SUPPLEMENT FOR EXPANSION	-$36,713
2023	2020	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	8/28/2023	NON-COMPETING CONTINUATION	-$383,920
														Subtotal = $377,701

Issue Date FY: 2022 ( Subtotal = $1 )
2022	2022	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	16	8/29/2022	COMPETING CONTINUATION	$1
2022	2022	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	16	9/19/2022	COMPETING CONTINUATION	$0
														Subtotal = $1

Issue Date FY: 2020 ( Subtotal = $492,190 )
2020	2020	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	15	9/1/2020	SUPPLEMENT FOR EXPANSION	$108,270
2020	2020	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	8/13/2020	NON-COMPETING CONTINUATION	$383,920
														Subtotal = $492,190

Issue Date FY: 2019 ( Subtotal = $380,986 )
2019	2019	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	14	8/23/2019	NON-COMPETING CONTINUATION	$380,986
														Subtotal = $380,986

Issue Date FY: 2018 ( Subtotal = $383,920 )
2018	2018	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	13	9/12/2018	NON-COMPETING CONTINUATION	$383,920
														Subtotal = $383,920

Issue Date FY: 2017 ( Subtotal = $383,920 )
2017	2017	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	12	9/1/2017	NON-COMPETING CONTINUATION	$383,920
2017	2016	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	11	12/28/2016	COMPETING CONTINUATION	$211,653
2017	2015	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	12/28/2016	NON-COMPETING CONTINUATION	-$211,653
														Subtotal = $383,920

Issue Date FY: 2016 ( Subtotal = $383,920 )
2016	2016	UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION	SERVICE COMPLEX	LOUISVILLE	KY	40292	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	11	9/23/2016	COMPETING CONTINUATION	$383,920
2016	2015	UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION	SERVICE COMPLEX	LOUISVILLE	KY	40292	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	9/20/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $383,920

Issue Date FY: 2015 ( Subtotal = $299,739 )
2015	2015	UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION	SERVICE COMPLEX	LOUISVILLE	KY	40292	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	9/9/2015	NON-COMPETING CONTINUATION	$299,739
														Subtotal = $299,739

Issue Date FY: 2014 ( Subtotal = $314,739 )
2014	2014	UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION	SERVICE COMPLEX	LOUISVILLE	KY	40292	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	9	9/16/2014	NON-COMPETING CONTINUATION	$314,739
														Subtotal = $314,739

Issue Date FY: 2013 ( Subtotal = $282,716 )
2013	2013	UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION	SERVICE COMPLEX	LOUISVILLE	KY	40292	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	8	9/5/2013	NON-COMPETING CONTINUATION	$282,716
														Subtotal = $282,716

Issue Date FY: 2012 ( Subtotal = $314,739 )
2012	2012	UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION	SERVICE COMPLEX	LOUISVILLE	KY	40292	JEFFERSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	7	9/14/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$314,739
														Subtotal = $314,739

Issue Date FY: 2011 ( Subtotal = $368,409 )
2011	2011	UNIVERSITY OF MISSISSIPPI MEDICAL CENTER	2500 NORTH STATE STREET	JACKSON	MS	39216	HINDS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	6	9/1/2011	COMPETING CONTINUATION	$368,409
2011	2010	UNIVERSITY OF MISSISSIPPI MEDICAL CENTER	2500 NORTH STATE STREET	JACKSON	MS	39216	HINDS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	8/30/2011	NON-COMPETING CONTINUATION	$0
														Subtotal = $368,409

Issue Date FY: 2010 ( Subtotal = $406,930 )
2010	2010	UNIVERSITY OF MISSISSIPPI MEDICAL CENTER	2500 NORTH STATE STREET	JACKSON	MS	39216	HINDS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	6/25/2010	NON-COMPETING CONTINUATION	$406,930
														Subtotal = $406,930

Issue Date FY: 2009 ( Subtotal = $496,122 )
2009	2009	UNIVERSITY OF MISSISSIPPI MEDICAL CENTER	2500 NORTH STATE STREET	JACKSON	MS	39216	HINDS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	4	7/28/2009	NON-COMPETING CONTINUATION	$0
2009	2009	UNIVERSITY OF MISSISSIPPI MEDICAL CENTER	2500 NORTH STATE STREET	JACKSON	MS	39216	HINDS	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	6/15/2009	NON-COMPETING CONTINUATION	$346,376
2009	2009	UNIVERSITY OF MISSISSIPPI MEDICAL CENTER	2500 NORTH STATE STREET	JACKSON	MS	39216	HINDS	USA	Trans-NIH Recovery Act Research Support	002	4	8/26/2009	SUPPLEMENT FOR EXPANSION	$149,746
														Subtotal = $496,122

Issue Date FY: 2008 ( Subtotal = $341,262 )
2008	2008	UNIVERSITY OF MISSISSIPPI MEDICAL CENTER	2500 NORTH STATE STREET	JACKSON	MS	39216	HINDS	USA	Digestive Diseases and Nutrition Research	000	3	4/16/2008	NON-COMPETING CONTINUATION	$341,262
														Subtotal = $341,262

Issue Date FY: 2007 ( Subtotal = $355,757 )
2007	2007	UNIVERSITY OF MISSISSIPPI MEDICAL CENTER	2500 NORTH STATE STREET	JACKSON	MS	39216	HINDS	USA	Digestive Diseases and Nutrition Research	001	2	9/20/2007	SUPPLEMENT FOR EXPANSION	$9,750
2007	2007	UNIVERSITY OF MISSISSIPPI MEDICAL CENTER	2500 NORTH STATE STREET	JACKSON	MS	39216	HINDS	USA	Digestive Diseases and Nutrition Research	000	2	5/22/2007	NON-COMPETING CONTINUATION	$346,007
														Subtotal = $355,757

Issue Date FY: 2006 ( Subtotal = $340,672 )
2006	2006	UNIVERSITY OF MISSISSIPPI MEDICAL CENTER	2500 NORTH STATE STREET	JACKSON	MS	39216	HINDS	USA	Digestive Diseases and Nutrition Research	000	1	4/6/2006	NEW	$340,672
														Subtotal = $340,672

Grand Total All Awards = $6,289,797

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U of L Clinical Center to Investigate the Pathogenesis, Etiology, and Treatment of Gastroparesis through the NIDDK Gastroparesis Consortium

Award Number: U01DK074007

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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