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Chronic Kidney Disease in Children (CKiD)

Award Number: U01DK066174
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2003
PERIOD OF PERFORMANCE END DATE: 07/31/2028

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Chronic Kidney Disease in Children (CKiD) - PROJECT SUMMARY/ABSTRACT For the Chronic Kidney Disease in Children (CKiD) Study renewal, we will continue to follow our existing cohort, and will recruit children between 14 and 17 years of age to enhance the power of the study to characterize the decline of kidney function and the development of cardiovascular disease as they transition to young adulthood. Remote data collection will be coordinated and conducted through national laboratory contractors who can assess vitals and obtain labs in the participant’s home. Data will be obtained between CKiD study visits by conducting data extraction through electronic health records. The Research Electronic Data Capture (REDCap) system will be leveraged to allow automated reporting for coordination and clinical activities and improve options for harmonization with external cohorts including CureGN and NEPTUNE. Most importantly, it will enable the study to collect data through web-based entry by computer or mobile phone directly by participants. Important research questions will include (a) methods to identify risk factors for decline in kidney function during childhood through young adulthood including acceleration of glomerular filtration rate (GFR) decline during puberty and the effect of acute kidney injury (AKI) on chronic kidney disease (CKD); (b) statistical-based machine learning prediction methodology to characterize the joint predictive value of clinical markers and social determinants of disease progression for individualized inference; (c) analytic strategies to describe risk factors for cardiovascular changes and outcomes via home blood pressure monitoring and assessing cardiac and vascular target organ damage, including characterizing changes in biomarkers like trajectories of indicators of metabolic bone health; (d) statistical methods to validate and refine GFR equations in young adulthood for consistent estimates during the transition from pediatric to adult care; and (e) methods to assess effects of therapies and exposures on outcomes including constructs of social function and emotional well-being.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,307,005 )
2026	2026	THE CHILDREN'S HOSPITAL OF PHILADELPHIA	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	25	7/31/2026	NON-COMPETING CONTINUATION	$0
2026	2026	THE CHILDREN'S HOSPITAL OF PHILADELPHIA	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	25	7/24/2026	NON-COMPETING CONTINUATION	$1,307,005
2026	2025	THE CHILDREN'S HOSPITAL OF PHILADELPHIA	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	24	6/2/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,307,005

Issue Date FY: 2025 ( Subtotal = $1,338,229 )
2025	2025	THE CHILDREN'S HOSPITAL OF PHILADELPHIA	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	24	7/30/2025	NON-COMPETING CONTINUATION	$1,338,229
2025	2024	THE CHILDREN'S HOSPITAL OF PHILADELPHIA	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	23	7/18/2025	NON-COMPETING CONTINUATION	$0
2025	2024	THE CHILDREN'S HOSPITAL OF PHILADELPHIA	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	23	3/4/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,338,229

Issue Date FY: 2024 ( Subtotal = $1,304,705 )
2024	2024	THE CHILDREN'S HOSPITAL OF PHILADELPHIA	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	004	23	7/5/2024	NON-COMPETING CONTINUATION	$1,304,705
2024	2023	THE CHILDREN'S HOSPITAL OF PHILADELPHIA	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	22	5/28/2024	COMPETING CONTINUATION	$0
2024	2023	THE CHILDREN'S HOSPITAL OF PHILADELPHIA	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	22	6/27/2024	COMPETING CONTINUATION	$167,600
2024	2023	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	22	12/4/2023	COMPETING CONTINUATION	$0
2024	2022	THE CHILDREN'S HOSPITAL OF PHILADELPHIA	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	21	6/27/2024	NON-COMPETING CONTINUATION	-$167,600
														Subtotal = $1,304,705

Issue Date FY: 2023 ( Subtotal = $1,463,350 )
2023	2023	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	22	9/14/2023	COMPETING CONTINUATION	$1,463,350
2023	2022	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	21	3/3/2023	NON-COMPETING CONTINUATION	$0
2023	2022	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	21	6/27/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,463,350

Issue Date FY: 2022 ( Subtotal = $1,151,446 )
2022	2022	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	21	8/1/2022	NON-COMPETING CONTINUATION	$1,151,446
2022	2021	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	20	11/24/2021	NON-COMPETING CONTINUATION	$0
2022	2021	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	20	5/13/2022	NON-COMPETING CONTINUATION	$0
2022	2017	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	16	8/29/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,151,446

Issue Date FY: 2021 ( Subtotal = $1,189,084 )
2021	2021	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	20	8/5/2021	NON-COMPETING CONTINUATION	$1,189,084
2021	2020	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	19	3/8/2021	NON-COMPETING CONTINUATION	$0
2021	2020	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	19	11/16/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,189,084

Issue Date FY: 2020 ( Subtotal = $1,143,438 )
2020	2020	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	19	7/13/2020	NON-COMPETING CONTINUATION	$1,143,438
2020	2019	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	18	12/3/2019	NON-COMPETING CONTINUATION	$0
2020	2019	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	18	6/9/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,143,438

Issue Date FY: 2019 ( Subtotal = $1,131,853 )
2019	2019	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	005	18	7/31/2019	NON-COMPETING CONTINUATION	$1,131,853
2019	2019	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	006	18	8/28/2019	NON-COMPETING CONTINUATION	$0
2019	2018	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	007	17	9/6/2019	COMPETING CONTINUATION	$0
2019	2018	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	17	12/31/2018	COMPETING CONTINUATION	$0
2019	2018	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	17	4/19/2019	COMPETING CONTINUATION	$0
2019	2018	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	004	17	7/9/2019	COMPETING CONTINUATION	$0
2019	2018	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	17	12/3/2018	COMPETING CONTINUATION	$328,790
2019	2017	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	16	12/3/2018	NON-COMPETING CONTINUATION	-$328,790
														Subtotal = $1,131,853

Issue Date FY: 2018 ( Subtotal = $1,212,927 )
2018	2018	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	17	9/14/2018	COMPETING CONTINUATION	$1,212,927
2018	2018	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	17	9/20/2018	COMPETING CONTINUATION	$0
2018	2017	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	16	8/30/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,212,927

Issue Date FY: 2017 ( Subtotal = $964,088 )
2017	2017	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	16	8/23/2017	NON-COMPETING CONTINUATION	$964,088
2017	2016	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	15	12/8/2016	EXTENSION WITH OR WITHOUT FUNDS	$433,026
2017	2015	CHILDREN'S HOSPITAL OF PHILADELPHIA, THE	3401 CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	14	12/8/2016	NON-COMPETING CONTINUATION	-$433,026
														Subtotal = $964,088

Issue Date FY: 2016 ( Subtotal = $1,221,966 ) (Continued on the next page)
2016	2016	CHILDREN'S HOSPITAL OF PHILADELPHIA	34TH ST & CIVIC CENTER BLVD	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	7/28/2016	EXTENSION WITH OR WITHOUT FUNDS	$971,966
Grand Total All Awards = $24,366,938

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Chronic Kidney Disease in Children (CKiD)

Award Number: U01DK066174

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2003

PERIOD OF PERFORMANCE END DATE: 07/31/2028

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