Thursday, January 2, 2025 1/2/2025

Montreal-Boston Collaborative IBD Genetic Research Center

Award Number: U01DK062432
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT ABSTRACT The inflammatory bowel diseases (IBD) are characterized by chronic relapsing inflammation of the gastrointestinal tract. Crohn's disease (CD) (MIM 266600) and UC (MIM 191390) are the two main subtypes of IBD. The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) was established in July 2002 for the purpose of identifying genetic variation predisposing to IBD. The Montreal-Boston Collaborative IBD Genetic Research Center (GRC), is a founding member of the IBDGC. In the current proposal we have three Specific Aims: SA#1: To characterize the genetic architecture of IBD phenotypes within populations currently underrepresented in IBD genomic research. OBJECTIVE: To employ local ancestry decomposition to identify variants uniquely enriched in US admixed samples to identify previously overlooked genetic risk factors contributing more substantially to IBD in Hispanic and African-American populations. SA#2: To exploit longitudinal multi `omic approaches to reveal the biological causes of the clinical heterogeneity of IBD and differential treatment response. OBJECTIVE: To recruit and prospectively follow IBD patients following the initiation of molecularly-targeted therapies. We will generate and/or analyze genetic, serum metabolomics, and blood single-cell RNA-sequencing data and test baseline samples (immediately prior to initiation of therapy) and samples taken at first clinical assessment. Patients will be followed for a period of one year. SA#3: Analysis of the newly identified CD gene PDLIM5 and its splice region variant and their impact on epithelial functions. OBJECTIVE: To determine the function of a newly identified CD gene and placing it in the biological context of other IBD genes using patient-derived materials, organoids and hiPSC-based models. We are committed to including both sexes in our genetic and functional studies, including sex as a variable in our data collection, analysis of results, and reporting of findings. This includes patient-derived cellular models (e.g. hiPSC-derived lines). We will also ensure that the experiments are done on diverse genetic backgrounds and determine if this impacts the effect of perturbation or baseline behavior of the assay and/or model.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$97,721 )
2025	2021	INSTITUT DE CARDIOLOGIE DE MONTREAL	5000 RUE BELANGER	MONTREAL	QC			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	21	10/1/2024	NON-COMPETING CONTINUATION	-$21,200
2025	2021	INSTITUT DE CARDIOLOGIE DE MONTREAL	5000 RUE BELANGER	MONTREAL	QC			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	21	10/1/2024	NON-COMPETING CONTINUATION	-$76,521
														Subtotal = -$97,721

Issue Date FY: 2024 ( Subtotal = $465,503 )
2024	2024	INSTITUT DE CARDIOLOGIE DE MONTREAL	5000 RUE BELANGER	MONTREAL	QC			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	24	8/27/2024	SUPPLEMENT FOR EXPANSION	$221,875
2024	2024	INSTITUT DE CARDIOLOGIE DE MONTREAL	5000 RUE BELANGER	MONTREAL	QC			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	24	7/11/2024	NON-COMPETING CONTINUATION	$243,628
2024	2023	INSTITUT DE CARDIOLOGIE DE MONTREAL	5000 RUE BELANGER	MONTREAL	QC			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	23	2/9/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $465,503

Issue Date FY: 2023 ( Subtotal = $483,409 )
2023	2023	INSTITUT DE CARDIOLOGIE DE MONTREAL	5000 RUE BELANGER	MONTREAL	QC			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	004	23	8/31/2023	NON-COMPETING CONTINUATION	$483,409
2023	2022	INSTITUT DE CARDIOLOGIE DE MONTREAL	5000 RUE BELANGER	MONTREAL	QC			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	22	8/29/2023	COMPETING CONTINUATION	$122,721
2023	2021	INSTITUT DE CARDIOLOGIE DE MONTREAL	5000 RUE BELANGER	MONTREAL	QC			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	21	5/15/2023	NON-COMPETING CONTINUATION	$0
2023	2021	INSTITUT DE CARDIOLOGIE DE MONTREAL	5000 RUE BELANGER	MONTREAL	QC			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	21	8/29/2023	NON-COMPETING CONTINUATION	-$122,721
2023	2021	INSTITUT DE CARDIOLOGIE DE MONTREAL	5000 RUE BELANGER	MONTREAL	QC			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	21	8/23/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $483,409

Issue Date FY: 2022 ( Subtotal = $361,767 )
2022	2022	INSTITUT DE CARDIOLOGIE DE MONTREAL	5000 RUE BELANGER	MONTREAL	PQ			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	22	9/21/2022	COMPETING CONTINUATION	$361,767
2022	2021	INSTITUT DE CARDIOLOGIE DE MONTREAL	5000 RUE BELANGER	MONTREAL	PQ			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	21	9/12/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $361,767

Issue Date FY: 2021 ( Subtotal = $404,495 )
2021	2021	INSTITUT DE CARDIOLOGIE DE MONTREAL	5000 RUE BELANGER	MONTREAL	PQ			CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	21	9/6/2021	NON-COMPETING CONTINUATION	$404,495
														Subtotal = $404,495

Issue Date FY: 2020 ( Subtotal = $513,027 )
2020	2020	INSTITUT DE CARDIOLOGIE DE MONTREAL	5000 RUE BELANGER	MONTREAL	PQ	H1T 1C8		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	20	8/13/2020	NON-COMPETING CONTINUATION	$405,039
2020	2020	INSTITUT DE CARDIOLOGIE DE MONTREAL	5000 RUE BELANGER	MONTREAL	PQ	H1T 1C8		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	20	8/18/2020	SUPPLEMENT FOR EXPANSION	$107,988
														Subtotal = $513,027

Issue Date FY: 2019 ( Subtotal = $496,435 )
2019	2019	INSTITUT DE CARDIOLOGIE DE MONTREAL	5000 RUE BELANGER	MONTREAL	PQ	H1T 1C8		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	19	9/13/2019	SUPPLEMENT FOR EXPANSION	$0
2019	2019	INSTITUT DE CARDIOLOGIE DE MONTREAL	5000 RUE BELANGER	MONTREAL	PQ	H1T 1C8		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	19	8/23/2019	NON-COMPETING CONTINUATION	$388,435
2019	2019	INSTITUT DE CARDIOLOGIE DE MONTREAL	5000 RUE BELANGER	MONTREAL	PQ	H1T 1C8		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	19	9/11/2019	SUPPLEMENT FOR EXPANSION	$108,000
														Subtotal = $496,435

Issue Date FY: 2018 ( Subtotal = $497,821 )
2018	2018	INSTITUT DE CARDIOLOGIE DE MONTREAL	5000 RUE BELANGER	MONTREAL	PQ	H1T 1C8		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	18	9/14/2018	SUPPLEMENT FOR EXPANSION	$108,000
2018	2018	INSTITUT DE CARDIOLOGIE DE MONTREAL	5000 RUE BELANGER	MONTREAL	PQ	H1T 1C8		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	18	9/7/2018	NON-COMPETING CONTINUATION	$389,821
2018	2017	INSTITUT DE CARDIOLOGIE DE MONTREAL	5000 RUE BELANGER	MONTREAL	PQ	H1T 1C8		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	17	2/9/2018	COMPETING CONTINUATION	$122,721
2018	2016	INSTITUT DE CARDIOLOGIE DE MONTREAL	5000 RUE BELANGER	MONTREAL	PQ	H1T 1C8		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	16	2/9/2018	NON-COMPETING CONTINUATION	-$122,721
														Subtotal = $497,821

Issue Date FY: 2017 ( Subtotal = $402,114 )
2017	2017	INSTITUT DE CARDIOLOGIE DE MONTREAL	5000 RUE BELANGER	MONTREAL	PQ	H1T 1C8		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	17	9/19/2017	COMPETING CONTINUATION	$402,114
														Subtotal = $402,114

Issue Date FY: 2016 ( Subtotal = $499,025 )
2016	2016	INSTITUTION DE CARDIOLOGIE DE MONTREAL	5000 EAST BELANGER STREET	MONTREAL, QUEBEC				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	16	9/15/2016	NON-COMPETING CONTINUATION	$499,025
														Subtotal = $499,025

Issue Date FY: 2015 ( Subtotal = $364,222 )
2015	2015	INSTITUTION DE CARDIOLOGIE DE MONTREAL	5000 EAST BELANGER STREET	MONTREAL, QUEBEC				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	9/18/2015	NON-COMPETING CONTINUATION	$364,222
														Subtotal = $364,222

Issue Date FY: 2014 ( Subtotal = $364,221 )
2014	2014	INSTITUTION DE CARDIOLOGIE DE MONTREAL	5000 EAST BELANGER STREET	MONTREAL, QUEBEC				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	14	9/12/2014	NON-COMPETING CONTINUATION	$364,221
														Subtotal = $364,221

Issue Date FY: 2013 ( Subtotal = $355,027 )
2013	2013	INSTITUTION DE CARDIOLOGIE DE MONTREAL	5000 EAST BELANGER STREET	MONTREAL, QUEBEC				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	13	9/12/2013	EXTENSION WITH OR WITHOUT FUNDS	$355,027
														Subtotal = $355,027

Issue Date FY: 2012 ( Subtotal = $364,221 )
2012	2012	INSTITUTION DE CARDIOLOGIE DE MONTREAL	5000 EAST BELANGER STREET	MONTREAL, QUEBEC				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	12	9/21/2012	COMPETING CONTINUATION	$364,221
2012	2011	INSTITUTION DE CARDIOLOGIE DE MONTREAL	5000 EAST BELANGER STREET	MONTREAL, QUEBEC		00000		CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	11	9/21/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $364,221

Issue Date FY: 2011 ( Subtotal = $273,938 )
2011	2011	INSTITUTION DE CARDIOLOGIE DE MONTREAL	5000 EAST BELANGER STREET	MONTREAL, QUEBEC				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	11	9/13/2011	NON-COMPETING CONTINUATION	$273,938
														Subtotal = $273,938

Issue Date FY: 2010 ( Subtotal = $273,714 )
2010	2010	INSTITUTION DE CARDIOLOGIE DE MONTREAL	5000 EAST BELANGER STREET	MONTREAL, QUEBEC				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	9/20/2010	NON-COMPETING CONTINUATION	$273,714
														Subtotal = $273,714

Issue Date FY: 2009 ( Subtotal = $298,604 )
2009	2009	INSTITUTION DE CARDIOLOGIE DE MONTREAL	5000 EAST BELANGER STREET	MONTREAL, QUEBEC				CAN	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	9	9/11/2009	NON-COMPETING CONTINUATION	$298,604
2009	2006	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASS AVE, BLDG E19-583	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Digestive Diseases and Nutrition Research	000	6	3/27/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $298,604

Grand Total All Awards = $8,004,226

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Montreal-Boston Collaborative IBD Genetic Research Center

Award Number: U01DK062432

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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