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Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)

Award Number: U01DK061713
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2002
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) - In recent decades, Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD), formerly known as Non-Alcoholic Fatty Liver Disease (NAFLD), has become the most common chronic liver condition, leading to cirrhosis, hepatocellular carcinoma, and end-stage liver disease. This trend isn't confined to adults; children and adolescents are also affected, increasing the need for liver transplants among young adults. Two decades ago, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) established the Non- Alcoholic Steatohepatitis Clinical Research Network (NASH CRN) to advance clinical and translational research in adult and pediatric MASLD. Their mission is to translate scientific findings from lab, clinical, and population studies into practical applications, ultimately reducing MASLD incidence, slowing disease progression, and improving clinical outcomes. Over 20 years, NASH CRN has led NAFLD research, creating valuable databases, conducting randomized trials, and disseminating high-quality studies. Looking ahead, the CRN will leverage its established infrastructure and accumulated knowledge to develop diagnostic tests, biomarkers for disease progression, and safe, cost-effective NASH treatments. This renewal application aims to complete ongoing NASH CRN studies: Database 3 (DB3) and Vitamin E Dosing Study (VEDS). Furthermore, the Duke/Lurie Children's Memorial site proposes novel investigations focusing on accelerated senescence to predict high-risk populations in pediatric and adult cohorts. The central hypothesis is that patients prone to premature hepatocyte senescence are at greater risk of progressive liver degeneration, severe hepatic fibrosis, and higher morbidity and mortality due to MASLD. These investigations draw from recent research, utilizing existing data and biosamples while considering biological disparities to improve outcomes in pediatric and adult populations. The goal is to deepen our understanding of MASLD and pioneer innovative approaches for better disease management.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $250,001 )
2025	2025	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	24	7/3/2025	NON-COMPETING CONTINUATION	$250,001
2025	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	23	3/5/2025	COMPETING CONTINUATION	$3,806
2025	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	22	3/5/2025	NON-COMPETING CONTINUATION	-$3,806
														Subtotal = $250,001

Issue Date FY: 2024 ( Subtotal = $250,001 )
2024	2024	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	23	8/9/2024	COMPETING CONTINUATION	$250,001
2024	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	22	1/30/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $250,001

Issue Date FY: 2023 ( Subtotal = $280,975 )
2023	2023	DUKE UNIVERSITY	2200 W MAIN ST	DURHAM	NC	27705	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	22	7/19/2023	NON-COMPETING CONTINUATION	$280,975
														Subtotal = $280,975

Issue Date FY: 2022 ( Subtotal = $295,083 )
2022	2022	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	21	7/15/2022	NON-COMPETING CONTINUATION	$295,083
														Subtotal = $295,083

Issue Date FY: 2021 ( Subtotal = $342,742 )
2021	2021	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	20	7/15/2021	NON-COMPETING CONTINUATION	$310,083
2021	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	18	5/11/2021	COMPETING CONTINUATION	$32,659
														Subtotal = $342,742

Issue Date FY: 2020 ( Subtotal = $327,424 )
2020	2020	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	19	8/17/2020	NON-COMPETING CONTINUATION	$360,083
2020	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	17	2/12/2020	NON-COMPETING CONTINUATION	-$32,659
														Subtotal = $327,424

Issue Date FY: 2019 ( Subtotal = $484,485 )
2019	2019	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	18	9/12/2019	COMPETING CONTINUATION	$484,485
2019	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	17	9/9/2019	NON-COMPETING CONTINUATION	$0
2019	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	17	6/19/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $484,485

Issue Date FY: 2018 ( Subtotal = $472,040 )
2018	2018	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	17	8/13/2018	NON-COMPETING CONTINUATION	$472,040
														Subtotal = $472,040

Issue Date FY: 2017 ( Subtotal = $396,804 )
2017	2017	DUKE UNIVERSITY	2200 W MAIN ST STE 710	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	16	8/17/2017	NON-COMPETING CONTINUATION	$396,804
														Subtotal = $396,804

Issue Date FY: 2016 ( Subtotal = $385,000 )
2016	2016	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	7/29/2016	NON-COMPETING CONTINUATION	$385,000
														Subtotal = $385,000

Issue Date FY: 2015 ( Subtotal = $547,104 )
2015	2015	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	13	2/5/2015	SUPPLEMENT FOR EXPANSION	$97,104
2015	2015	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	14	7/1/2015	NON-COMPETING CONTINUATION	$450,000
														Subtotal = $547,104

Issue Date FY: 2014 ( Subtotal = $561,765 )
2014	2014	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	13	7/24/2014	COMPETING CONTINUATION	$561,765
2014	2013	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	12	7/21/2014	SUPPLEMENT FOR EXPANSION	$0
2014	2013	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	12	7/21/2014	SUPPLEMENT FOR EXPANSION	$0
2014	2013	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	12	7/21/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $561,765

Issue Date FY: 2013 ( Subtotal = $858,311 )
2013	2013	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	12	9/12/2013	SUPPLEMENT FOR EXPANSION	$88,447
2013	2013	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	11	2/4/2013	SUPPLEMENT FOR EXPANSION	$158,883
2013	2013	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	12	9/13/2013	SUPPLEMENT FOR EXPANSION	$273,749
2013	2013	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	12	8/26/2013	NON-COMPETING CONTINUATION	$337,232
														Subtotal = $858,311

Issue Date FY: 2012 ( Subtotal = $511,429 )
2012	2012	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	11	7/27/2012	NON-COMPETING CONTINUATION	$511,429
														Subtotal = $511,429

Issue Date FY: 2011 ( Subtotal = $470,848 )
2011	2011	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	10	7/14/2011	NON-COMPETING CONTINUATION	$470,848
2011	2010	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Recovery Act Research Support	000	8	1/6/2011	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $470,848

Issue Date FY: 2010 ( Subtotal = $635,091 )
2010	2010	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	9	7/8/2010	NON-COMPETING CONTINUATION	$485,187
2010	2010	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Trans-NIH Recovery Act Research Support	000	8	1/25/2010	SUPPLEMENT FOR EXPANSION	$149,904
														Subtotal = $635,091

Issue Date FY: 2009 ( Subtotal = $314,528 ) (Continued on the next page)
2009	2009	DUKE UNIVERSITY	BOX 104004	DURHAM	NC	27708	DURHAM	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	8	8/10/2009	COMPETING CONTINUATION	$314,528
Grand Total All Awards = $9,721,012

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Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)

Award Number: U01DK061713

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2002

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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