Sunday, December 7, 2025 12/7/2025

Comparative Modeling of Precision Breast Cancer Control Across the Translational Continuum Administrative Supplement

Award Number: U01CA253911
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2020
PERIOD OF PERFORMANCE END DATE: 08/31/2026

Group Awards By:

View Award Description

Comparative Modeling of Precision Breast Cancer Control Across the Translational Continuum Administrative Supplement - ABSTRACT The CISNET Breast Working Group (BWG) conducts innovative modeling research focused on new precision oncology paradigms that are expected to re-define breast cancer control best practices. In the parent award, we selected significant topics where modeling is suited to fill evidence gaps and facilitate clinical and policy translation. The activities of this award have encompassed multiple lines of activity including analyses for the US Preventive Services Task Force, publishing a cross-CISNET monograph, dedicating Rapid Response funds to address priority areas for new investigation, and fostering the career of early-stage investigators. The models share common inputs and provide a standard set of outcomes for benefits (e.g., distant recurrences and deaths avoided, mortality reductions, life years and quality-adjusted life years), harms (e.g., false positives and benign biopsies, advanced stage diagnoses, overdiagnosis and treatment impact on quality of life), and costs. Unique components of our approach include modeling of absolute risk of disease accounting for multiple risk factors, evaluating emerging screening modalities, addressing important comorbidities—specifically type 2 diabetes—that affect both disease risk and survival, and providing guidance regarding new precision systemic treatments and their impact on outcomes among survivors. The specific aims of this extension are to: 1) complete manuscripts in progress; 2) fully implement common inputs that consider important recent trends in screening and treatment; 3) update documentation of program code and manuscript specifications; and 4) retain essential programming staff to complete coding, finalize documentation, and facilitate future use of breast cancer modeling resources. This scope of work would not be feasible without the availability of five distinctive BWG models: Dana Farber (D), Georgetown-Einstein (GE), MD Anderson (M), Stanford (S), and Wisconsin (W). This extension period will ensure that the BWG models are supported to incorporate the latest input data and record key decisions as a foundation for future use. Retention of key programming staff will guarantee that modeling resources will be updated, documented, and accessible for utilization in new studies. Continuously funded for the past 25 years, the modeling teams have published >230 research papers informing public health and trained >20 junior investigators. An experienced Coordinating Center provides the infrastructure to support the project goals including resource sharing and model accessibility. The exceptional environment provides unprecedented synergy and leveraging of resources to address new research questions and support career development that would not otherwise be possible. Overall, infrastructure support for the Breast Working Group will advance modeling research and guide breast cancer control decision making.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $566,636 )
2025	2025	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	000	5	8/28/2025	SUPPLEMENT FOR EXPANSION	$566,636
														Subtotal = $566,636

Issue Date FY: 2024 ( Subtotal = $1,508,560 )
2024	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	002	5	8/26/2024	NON-COMPETING CONTINUATION	$1,508,560
2024	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	001	4	3/15/2024	NON-COMPETING CONTINUATION	$0
2024	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	000	3	3/15/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,508,560

Issue Date FY: 2023 ( Subtotal = $1,791,871 )
2023	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	002	4	8/15/2023	NON-COMPETING CONTINUATION	$1,791,871
2023	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	000	3	4/24/2023	NON-COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	001	3	8/8/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,791,871

Issue Date FY: 2022 ( Subtotal = $2,330,404 )
2022	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	003	3	9/6/2022	SUPPLEMENT FOR EXPANSION	$34,980
2022	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Control	002	3	8/26/2022	SUPPLEMENT FOR EXPANSION	$503,760
2022	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	001	3	8/1/2022	NON-COMPETING CONTINUATION	$1,791,664
2022	2021	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	000	2	7/19/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,330,404

Issue Date FY: 2021 ( Subtotal = $2,471,366 )
2021	2021	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	001	2	7/26/2021	NON-COMPETING CONTINUATION	$1,827,604
2021	2021	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Cancer Control	003	2	8/24/2021	SUPPLEMENT FOR EXPANSION	$503,760
2021	2021	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	002	2	8/23/2021	NON-COMPETING CONTINUATION	$140,002
2021	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	000	1	11/13/2020	NEW	$0
														Subtotal = $2,471,366

Issue Date FY: 2020 ( Subtotal = $1,963,075 )
2020	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Cancer Cause and Prevention Research	000	1	9/1/2020	NEW	$1,963,075
														Subtotal = $1,963,075

Grand Total All Awards = $10,631,912

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Comparative Modeling of Precision Breast Cancer Control Across the Translational Continuum Administrative Supplement

Award Number: U01CA253911

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2020

PERIOD OF PERFORMANCE END DATE: 08/31/2026

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer