Monday, June 30, 2025 6/30/2025

Image-based models of tumor-immune dynamics in glioblastoma

Award Number: U01CA250481
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2021
PERIOD OF PERFORMANCE END DATE: 02/28/2026

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Image-based models of tumor-immune dynamics in glioblastoma - ABSTRACT The use of immunotherapy to treat cancer continues to generate hope and excitement among those involved in cancer care and research. However, our inability to explain why some patients do not respond to immunotherapy, combined with our inability to identify early response or predict the responders, poses serious challenges in this field. Currently, biopsies serve as the most informative way to assess the immunological activity within a cancerous area, but we are spatially and temporally limited in the number of biopsies we can obtain from patients, especially in cases of brain cancer. Clear evidence of tumor-immune environment heterogeneity across patients suggests that we will have to use an individualized approach in order to accurately assess patient tumor’s specific immune environment and the evolution of these complex systems. We propose to use computational modeling and artificial intelligence to bridge the spatial scales of the cellular content comprising each MRI at the voxel level, but also to bridge the temporal scales. We will focus on the most cellular immune population in glioblastoma, microglia/macrophages, that constitute as much as 50% of the cellular content of tumor specimens. By fusing MRI with the biological heterogeneity found in image- localized biopsies through such radiomics approaches provides an opportunity to individualize our understanding of the the tumor-immune environment, broadly benefiting scientists across the fields of oncology and immunology. In addition to providing a deeper understanding of the tumor at every imaging time point, the radiomics maps can also be used to parameterize dynamic mechanistic models of tumor growth to allow for prediction of future dynamics. These spatio-temporal models allow us to test hypotheses about causal relationships between different cell types and microenvironmental factors, as well as to verify whether the radiomics maps provide early dynamic insights into tumor response that can impact clinical decision making.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $559,690 )
2025	2025	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	001	5	5/14/2025	NON-COMPETING CONTINUATION	$0
2025	2025	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	000	5	4/15/2025	NON-COMPETING CONTINUATION	$559,690
														Subtotal = $559,690

Issue Date FY: 2024 ( Subtotal = $729,256 )
2024	2024	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	002	4	4/18/2024	NON-COMPETING CONTINUATION	$33,356
2024	2024	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	003	4	4/18/2024	SUPPLEMENT FOR EXPANSION	$5,025
2024	2024	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	001	4	3/6/2024	SUPPLEMENT FOR EXPANSION	$90,449
2024	2024	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	000	4	3/4/2024	NON-COMPETING CONTINUATION	$600,426
														Subtotal = $729,256

Issue Date FY: 2023 ( Subtotal = $746,529 )
2023	2023	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	000	3	2/28/2023	NON-COMPETING CONTINUATION	$810,933
2023	2023	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	003	3	6/12/2023	SUPPLEMENT FOR EXPANSION	$81,303
2023	2023	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	001	3	3/2/2023	SUPPLEMENT FOR EXPANSION	$10,574
2023	2023	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	002	3	4/4/2023	NON-COMPETING CONTINUATION	-$156,281
														Subtotal = $746,529

Issue Date FY: 2022 ( Subtotal = $888,889 )
2022	2022	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	005	2	8/19/2022	NON-COMPETING CONTINUATION	$0
2022	2022	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	002	2	3/2/2022	SUPPLEMENT FOR EXPANSION	$67,932
2022	2022	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	004	2	5/9/2022	SUPPLEMENT FOR EXPANSION	$6,039
2022	2022	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	003	2	4/25/2022	NON-COMPETING CONTINUATION	$53,508
2022	2022	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	001	2	2/28/2022	NON-COMPETING CONTINUATION	$601,942
2022	2022	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	006	2	8/31/2022	NON-COMPETING CONTINUATION	$159,468
2022	2021	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	000	1	1/11/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $888,889

Issue Date FY: 2021 ( Subtotal = $831,684 )
2021	2021	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	000	1	3/1/2021	NEW	$702,579
2021	2021	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	002	1	9/16/2021	SUPPLEMENT FOR EXPANSION	$46,105
2021	2021	MAYO CLINIC ARIZONA	13400 E SHEA BLVD	SCOTTSDALE	AZ	85259	MARICOPA	USA	Cancer Biology Research	001	1	7/26/2021	NEW	$83,000
														Subtotal = $831,684

Grand Total All Awards = $3,756,048

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Image-based models of tumor-immune dynamics in glioblastoma

Award Number: U01CA250481

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2021

PERIOD OF PERFORMANCE END DATE: 02/28/2026

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