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Development of a Total Nutrient Index

Award Number: U01CA215834
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/15/2017
PERIOD OF PERFORMANCE END DATE: 03/31/2028

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Development of a Total Nutrient Index - PROJECT SUMMARY Dietary indices and scores provide a comprehensive and robust approach for nutritional exposure assessment, especially in relation to chronic disease risk. While dietary supplement (DS) use is very common among the U.S. population, with over 52% of adults and 33% of children routinely taking one or more (predominantly nutrient containing) products, no existing metrics assessed intakes from DS in addition to those from the diet. For this reason, we developed the Total Nutrient Index (TNI), a measure designed to evaluate total usual micronutrient intakes, inclusive of intakes from foods and DS, relative to the Dietary Reference Intakes for eight micronutrients identified as under consumed among the U.S. population by the 2015-2020 Dietary Guidelines for Americans (DGA) in the first period of this award. We examined the relative validity of the TNI compared to biomarkers of nutritional status among a nationally representative sample of U.S. adults and determined that 1) the TNI is a useful metric for total micronutrient exposure assessment, and 2) that the TNI yielded higher correlations with nutritional biomarkers when compared with those obtained from dietary intake alone. However, with the emergence of the precision nutrition era, understanding how unique combinations of nutrients and specific amounts of these nutrients can optimize the nutritional and health status of different population subgroups is of utmost importance. Accordingly, in the present competing continuation proposal, we intend to update the TNI to accommodate a life stage approach, to utilize machine learning techniques to identify critical nutrients and in what combinations optimally benefit the health and nutrition of individuals across the life course, and relate the TNI to risk factors, health outcomes, and mortality. In Aim 1, we plan to develop and validate the TNI-2, an updated extension of the TNI that is tailored to different life stages and includes nutrients and food components of


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $296,164 )
2025	2025	TEXAS A&M AGRILIFE RESEARCH	2147 TAMU	COLLEGE STATION	TX	77843	BRAZOS	USA	Cancer Cause and Prevention Research	000	6	3/14/2025	NON-COMPETING CONTINUATION	$266,547
2025	2025	TEXAS A&M AGRILIFE RESEARCH	2147 TAMU	COLLEGE STATION	TX	77843	BRAZOS	USA	Cancer Cause and Prevention Research	001	6	5/22/2025	NON-COMPETING CONTINUATION	$29,617
														Subtotal = $296,164

Issue Date FY: 2024 ( Subtotal = $281,646 )
2024	2024	TEXAS A&M AGRILIFE RESEARCH	2147 TAMU	COLLEGE STATION	TX	77843	BRAZOS	USA	Cancer Cause and Prevention Research	000	5	3/21/2024	COMPETING CONTINUATION	$281,646
2024	2024	TEXAS A&M AGRILIFE RESEARCH	2147 TAMU	COLLEGE STATION	TX	77843	BRAZOS	USA	Cancer Cause and Prevention Research	001	5	9/4/2024	COMPETING CONTINUATION	$0
														Subtotal = $281,646

Issue Date FY: 2023 ( Subtotal = -$9,995 )
2023	2020	PURDUE UNIVERSITY	2550 NORTHWESTERN AVE STE 1900	WEST LAFAYETTE	IN	47906	TIPPECANOE	USA	Cancer Cause and Prevention Research	000	4	12/2/2022	NON-COMPETING CONTINUATION	-$9,995
														Subtotal = -$9,995

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	PURDUE UNIVERSITY	2550 NORTHWESTERN AVE STE 1900	WEST LAFAYETTE	IN	47906	TIPPECANOE	USA	Cancer Cause and Prevention Research	000	4	7/18/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	PURDUE UNIVERSITY	155 S GRANT ST	WEST LAFAYETTE	IN	47907	TIPPECANOE	USA	Cancer Cause and Prevention Research	000	4	11/10/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $342,157 )
2020	2020	PURDUE UNIVERSITY	155 S GRANT ST	WEST LAFAYETTE	IN	47907	TIPPECANOE	USA	Cancer Cause and Prevention Research	001	4	5/29/2020	NON-COMPETING CONTINUATION	$342,157
2020	2019	PURDUE UNIVERSITY	155 S GRANT ST	WEST LAFAYETTE	IN	47907	TIPPECANOE	USA	Cancer Cause and Prevention Research	000	3	11/22/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $342,157

Issue Date FY: 2019 ( Subtotal = $331,894 )
2019	2019	PURDUE UNIVERSITY	401 SOUTH GRANT ST	WEST LAFAYETTE	IN	47907	TIPPECANOE	USA	Cancer Cause and Prevention Research	001	3	4/22/2019	NON-COMPETING CONTINUATION	$331,894
2019	2018	PURDUE UNIVERSITY	401 SOUTH GRANT ST	WEST LAFAYETTE	IN	47907	TIPPECANOE	USA	Cancer Cause and Prevention Research	000	2	1/18/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $331,894

Issue Date FY: 2018 ( Subtotal = $348,136 )
2018	2018	PURDUE UNIVERSITY	401 SOUTH GRANT ST	WEST LAFAYETTE	IN	47907	TIPPECANOE	USA	Cancer Cause and Prevention Research	001	2	5/21/2018	NON-COMPETING CONTINUATION	$348,136
2018	2017	PURDUE UNIVERSITY	401 SOUTH GRANT ST	WEST LAFAYETTE	IN	47907	TIPPECANOE	USA	Cancer Cause and Prevention Research	000	1	2/19/2018	NEW	$0
														Subtotal = $348,136

Grand Total All Awards = $1,590,002

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Development of a Total Nutrient Index

Award Number: U01CA215834

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/15/2017

PERIOD OF PERFORMANCE END DATE: 03/31/2028

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