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Quantitative Imaging Clinical Validation Center at Moffitt Cancer Center

Award Number: U01CA200464
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/22/2016
PERIOD OF PERFORMANCE END DATE: 08/31/2028

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Quantitative Imaging Clinical Validation Center at Moffitt Cancer Center - PROJECT SUMMARY/ABSTRACT An overarching goal of cancer screening is to detect cancer at an early stage while it is localized, treatable, and curable. However, cancer screening is associated with false positives, high rates of indeterminate findings, overdiagnosis, and overtreatment, which are serious limitations that need to be addressed to improve early detection efforts. Because medical imaging is a key component of early detection for many cancers, quantitative imaging/radiomics can provide biomarkers to address many of these limitations with early detection. Our group, Quantitative Imaging Clinical Validation Center at Moffitt Cancer Center (QICVC-MCC), helped pioneer image biomarker approaches leveraged in the prior funding cycle to create the first and only EDRN Clinical Validation Center (CVC) dedicated to the validation of image biomarkers. For breast cancer, we validated several breast density-type risk markers and diagnostic models in women classified as BI-RADS 4, noting the three subcategories within this classification were strong diagnostic markers, and constructed a bio-image repository for this subgroup. For lung cancer, we conducted extensive studies applying conventional radiomics for risk prediction, discrimination between malignant and benign nodules, distinguishing between indolent and aggressive lung cancers, predicting tumor mutations, and predicting treatment response. In this renewal, we will expand our CVC from validated conventional feature-based radiomics as a benchmark to compare end-to-end deep learning (DL) methods, expand to other populations, and implement AI platforms for analyzing breast, lung, and other organ site images. In breast imaging (Aim 1), we will expand our efforts from parametric modeling to machine learning/DL for improved risk, early detection, and diagnostic predictions and continue our data repository developments. In lung imaging (Aim 2), we will expand our efforts from lung cancer screening to incidentally detected nodules and surgically resected early-stage lung cancer. Additionally, in Aim 3 we will seek out additional opportunities within the EDRN to conduct studies of image biomarkers in other organ sites beyond breast and lung (e.g., prostate, pancreas, and cutaneous) to address emerging Network objectives. The EDRN has proven that it is greater than the sum of the individual projects. As such, in Aim 4 we propose to build a repository for the housing and sharing of images, algorithms, radiomics, clinical data, and information on biospecimens. In this CVC renewal, we will systematically validate radiomic features and novel image metrics in the early detection of cancer. This research is significant because such information may be able to complement existing clinical guidelines and lead to new strategies to apply noninvasive image biomarkers. The research of the QICVC-MCC is performed at an NCI-Designated Comprehensive Cancer Center, which is an outstanding environment to conduct such studies given the access to large patient populations and outstanding resources, and the clinical setting to deploy such biomarkers for improved personalized cancer care.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 USF MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Detection and Diagnosis Research	000	8	4/24/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $1,322,710 )
2025	2025	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 USF MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Detection and Diagnosis Research	000	8	9/4/2025	NON-COMPETING CONTINUATION	$1,322,710
														Subtotal = $1,322,710

Issue Date FY: 2024 ( Subtotal = $1,301,697 )
2024	2024	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 USF MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Detection and Diagnosis Research	001	7	9/4/2024	NON-COMPETING CONTINUATION	$1,256,574
2024	2023	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 USF MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Detection and Diagnosis Research	000	6	8/1/2024	COMPETING CONTINUATION	$45,123
														Subtotal = $1,301,697

Issue Date FY: 2023 ( Subtotal = $836,497 )
2023	2023	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Detection and Diagnosis Research	001	6	9/22/2023	COMPETING CONTINUATION	$881,620
2023	2021	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Detection and Diagnosis Research	000	5	9/13/2023	SUPPLEMENT FOR EXPANSION	-$45,123
														Subtotal = $836,497

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Detection and Diagnosis Research	001	5	3/31/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2021	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Detection and Diagnosis Research	003	5	6/15/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2020	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Detection and Diagnosis Research	000	5	3/31/2022	NON-COMPETING CONTINUATION	$0
2022	2020	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Detection and Diagnosis Research	002	5	6/15/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $467,624 )
2021	2021	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Detection and Diagnosis Research	001	5	5/13/2021	SUPPLEMENT FOR EXPANSION	$467,624
2021	2020	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Detection and Diagnosis Research	000	5	12/2/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $467,624

Issue Date FY: 2020 ( Subtotal = $879,340 )
2020	2020	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Detection and Diagnosis Research	000	5	4/9/2020	NON-COMPETING CONTINUATION	$879,340
														Subtotal = $879,340

Issue Date FY: 2019 ( Subtotal = $918,681 )
2019	2019	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Detection and Diagnosis Research	002	4	9/20/2019	NON-COMPETING CONTINUATION	$92,133
2019	2019	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Detection and Diagnosis Research	001	4	4/4/2019	NON-COMPETING CONTINUATION	$826,548
2019	2018	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Detection and Diagnosis Research	000	3	10/24/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $918,681

Issue Date FY: 2018 ( Subtotal = $725,817 )
2018	2018	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Detection and Diagnosis Research	002	3	9/19/2018	NON-COMPETING CONTINUATION	$0
2018	2018	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Detection and Diagnosis Research	001	3	7/13/2018	NON-COMPETING CONTINUATION	$160,979
2018	2018	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Detection and Diagnosis Research	000	3	4/2/2018	NON-COMPETING CONTINUATION	$564,838
														Subtotal = $725,817

Issue Date FY: 2017 ( Subtotal = $717,012 )
2017	2017	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Detection and Diagnosis Research	001	2	6/8/2017	NON-COMPETING CONTINUATION	$71,702
2017	2017	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Detection and Diagnosis Research	000	2	3/23/2017	NON-COMPETING CONTINUATION	$645,310
														Subtotal = $717,012

Issue Date FY: 2016 ( Subtotal = $736,972 )
2016	2016	H LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE	12902 MAGNOLIA DRIVE	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Detection and Diagnosis Research	002	1	9/9/2016	SUPPLEMENT FOR EXPANSION	$29,974
2016	2016	H LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE	12902 MAGNOLIA DRIVE	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Detection and Diagnosis Research	001	1	6/29/2016	NEW	$13,958
2016	2016	H LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE	12902 MAGNOLIA DRIVE	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Detection and Diagnosis Research	000	1	6/24/2016	NEW	$693,040
														Subtotal = $736,972

Grand Total All Awards = $7,906,350

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Quantitative Imaging Clinical Validation Center at Moffitt Cancer Center

Award Number: U01CA200464

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/22/2016

PERIOD OF PERFORMANCE END DATE: 08/31/2028

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